scholarly journals A Geographical Mystery: Do Cardiotropic Viruses Respect National Borders?

2008 ◽  
Vol 52 (1) ◽  
pp. 82 ◽  
Author(s):  
Ali Yilmaz ◽  
Karin Klingel ◽  
Reinhard Kandolf ◽  
Udo Sechtem
Author(s):  
Seva Gunitsky

Over the past century, democracy spread around the world in turbulent bursts of change, sweeping across national borders in dramatic cascades of revolution and reform. This book offers a new global-oriented explanation for this wavelike spread and retreat—not only of democracy but also of its twentieth-century rivals, fascism, and communism. The book argues that waves of regime change are driven by the aftermath of cataclysmic disruptions to the international system. These hegemonic shocks, marked by the sudden rise and fall of great powers, have been essential and often-neglected drivers of domestic transformations. Though rare and fleeting, they not only repeatedly alter the global hierarchy of powerful states but also create unique and powerful opportunities for sweeping national reforms—by triggering military impositions, swiftly changing the incentives of domestic actors, or transforming the basis of political legitimacy itself. As a result, the evolution of modern regimes cannot be fully understood without examining the consequences of clashes between great powers, which repeatedly—and often unsuccessfully—sought to cajole, inspire, and intimidate other states into joining their camps.


2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Pham Van Loi

Vietnam - Laos has more than 2,000 km of common national borders. The coherent relationship between the two nations and the inhabitants of the two countries has been formed and fostered in history and especially developed over the past 7 decades. The Thai ethnic group in Vietnam has over one million people, residing permanently, concentrated in the Northwest region, the region consists of 8 provinces, of which 4 provinces have the Vietnam-Laos border crossing. This paper focuses on clarifying the practical basis for the Thai people to play a role in the traditional Vietnam-Laos friendship and propose some solutions to promote the role of Thai in maintaining, developing the traditional friendship between Vietnam and Laos, now and in the future.


2020 ◽  
Vol 49 (2) ◽  
pp. 281-308
Author(s):  
Ansgar Frenken

Abstract Reform or Papal Election – the Council and its Ordeal: An Inner-Conciliar Dispute between ‘Majority’ and ‘Minority’ at the Council of Constance. The broad consensus that prevailed among the Fathers at the beginning of the Council of Constance gave way to a climate of tension, at the latest after the resurgence of the English-French conflict in mid-1415, which made the inner tensions among the participants of the Council more and more apparent. The front that arose between ‘majority’ and ‘minority’ only followed ‘national’ borders to a limited extent, and for a long time it had not been firmly established, hence shifts and overlaps were still possible. The arrival of the Spaniards – first the Aragonese, later the Castilians – and the outbreak of the conflict of nations can be interpreted as key events in this development, which led to the formation of the two blocs. The national tensions between the English and the French were overlaid by the question of how the Council should proceed further: to proceed to the election of a new Pope first or to prioritize the reform of the church. For a long time both sides were in balance, but after the Castilians’ accession to the Council in the summer of 1417, the situation changed rapidly. The predominance of a coalition of Cardinals, Italica, Gallicana and the Castilians grew, while the group assembled around Sigmund, Germanica, Anglicana and the Aragonese increasingly eroded and became a ‘minority’. A finally negotiated compromise, in which both sides were able to save face, rendered a successful conclusion of the council possible.


2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
A Chaloupka ◽  
J Krejci ◽  
H Poloczkova ◽  
P Hude ◽  
E Ozabalova ◽  
...  

Abstract Background The aetiology of recent-onset dilated cardiomyopathy (RODCM) includes inflammatory, genetic, toxic and metabolic causes. Delineating the role of inflammation on the genetic background could improve risk stratification. Purpose We aimed to ascertain the role of inflammation evaluated by serum CRP immunohistochemical and PCR analysis of endomyocardial biopsy (EMB) in conjunction with genetic testing in left ventricular reverse remodelling (LVRR) in 12-month follow-up. Methods 83 RODCM patients enrolled in this prospective observational study underwent 12-month echocardiographic follow up whole-exome sequencing, and EMB. Presence of cardiotropic viruses was determined by PCR analysis of the EMB samples. Inflammation was defined according to TIMIC immunohistochemical criteria as the presence of >7 CD3+ lymphocytes/mm2 and/or >14 infiltrating leukocytes (LCA+ cells/mm2). LVRR was defined as an absolute increase in LV ejection fraction > +10% and a relative decrease of LV end-diastolic diameter >−10% at 12 months. Results LVRR occurred in 28 (34%) of all cases. PCR analysis uncovered cardiotropic viruses in 55 (66%) patients, with highest prevalence of parvovirus B19 (47%). (Figure 1) EMB analysis detected inflammation in 28 (34%) cases and inflammation significantly positively predicted LVRR (P=0.019). Sequencing identified disease-related gene variants (ACMG class 3–5) in 45 (54%) patients. Carriers of non-titin gene variants showed a lowest probability of 12-month LVRR (19%) P=0.041. Combination of genetic findings and inflammation did not improve the prediction of LVRR in 12 months. (Table 1) Conclusion Both myocardial inflammation and disease-causing variants can be identified in a large proportion of RODCM cases. Prognostic value of CRP and virus detection is low. Non-titin disease-related variants carriers of are less likely to reach LVRR. In contrast, myocardial inflammation detected by EMB predicts favourable remodelling in 12 months. Figure 1 Funding Acknowledgement Type of funding source: None


2000 ◽  
Vol 26 (2-3) ◽  
pp. 175-186
Author(s):  
Timothy S. Jost

If any trend can be confidently predicted for the next millennium (or, more modestly, for our lifetimes) it is the globalization of health law. We live in an age of global markets and global communications. While care of the individual patient has remained largely local, national borders are quite porous to health care professionals. The cross-border flow of patients is a significant factor in some regions, and the development of telemedicine and internet pharmacies is radically expanding the possibility of cross-border medical practice.


netWorker ◽  
2002 ◽  
Vol 6 (4) ◽  
pp. 20-25
Author(s):  
Aaron Weiss
Keyword(s):  

1995 ◽  
Vol 36 (4) ◽  
pp. 1055
Author(s):  
Robert P. Multhauf ◽  
Hideo Yoshikawa ◽  
Joanne Kauffman

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