TCTAP A-043 Neutrophil-to-Lymphocyte Ratio Associated with an Increased Risk of Mortality in Patients with Critical Limb Ischemia

Purpose Association of the neutrophil-to-lymphocyte ratio (NLR) with mortality has not been comprehensively explored in critical limb ischemia (CLI) patients. We investigated the association between the NLR and clinical outcomes in CLI. Materials and methods We retrospectively enrolled consecutive CLI patients between 1/1/2013 and 12/31/2018. Receiver operating characteristic curve analysis determined NLR cutoffs for 1-year in-hospital, all-cause and cardiac-related mortality; major adverse cardiovascular events (MACEs); and major adverse limb events (MALEs). Results Among 195 patients (age, 74.0 years, SD: 11.5; 51.8% male; body mass index, 23.4 kg/m2, SD: 4.2), 14.4% exhibited acute limb ischemia. After 1 year, patients with NLR>8 had higher in-hospital mortality (21.1% vs. 3.6%, P<0.001), all-cause mortality (54.4% vs. 13.8%, P<0.001), cardiac-related mortality (28.1% vs. 6.5%, P<0.001), MACE (29.8% vs. 13.0%, P = 0.008), and MALE (28.1% vs. 13.0%, P = 0.021) rates than those with NLR<8. In multivariate logistic regression, NLR≥8 was significantly associated with all-cause (P<0.001) and cardiac-related (adjusted HR: 5.286, 95% CI: 2.075–13.47, P<0.001) mortality, and NLR≥6 was significantly associated with MALEs (adjusted HR: 2.804, 95% CI: 1.292–6.088, P = 0.009). Each increase in the NLR was associated with increases in all-cause (adjusted HR: 1.028, 95% CI: 1.008–1.049, P = 0.007) and cardiac-related (adjusted HR:1.027, 95% CI: 0.998–1.057, P = 0.073) mortality but not in-hospital mortality or MACEs. Conclusion CLI patients with high NLRs had significantly higher risks of 1-year all-cause and cardiac-related mortality and MALEs. The NLR can be used for prognostic prediction in these patients.

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Neutrophil-to-lymphocyte Ratio Associated With an Increased Risk of Mortality in Patients With Critical Limb Ischemia

10.21203/rs.3.rs-243462/v1 ◽

2021 ◽

Author(s):

Min-I Su ◽

Cheng-Wei Liu

Keyword(s):

Critical Limb Ischemia ◽

Characteristic Curve ◽

Limb Ischemia ◽

Neutrophil To Lymphocyte Ratio ◽

Major Adverse Cardiovascular Events ◽

Acute Limb Ischemia ◽

Lymphocyte Ratio ◽

Increased Risk ◽

Prognostic Prediction ◽

Related Mortality

Abstract Purpose: Association of the neutrophil-to-lymphocyte ratio (NLR) with mortality has not been comprehensively explored in critical limb ischemia (CLI) patients. We investigated the association between the NLR and clinical outcomes in CLI.Materials and methods: We retrospectively enrolled consecutive CLI patients during 1/1/2013–12/31/2018. Receiver operating characteristic curve analysis determined NLR cutoffs for 1-year in-hospital, all-cause and cardiac-related mortality, and major adverse cardiovascular events (MACEs) and limb events (MALEs).Results: Among 195 patients (age, 74.0 years, SD: 11.5; 51.8% male; BMI, 23.4 kg/m2, SD: 4.2), 14.4% exhibited acute limb ischemia. After 1 year, patients with an NLR>8 had higher in-hospital mortality (21.1% vs. 3.6%, P<0.001), all-cause mortality (54.4% vs. 13.8%, P<0.001), cardiac-related mortality (28.1% vs. 6.5%, P<0.001), MACE (29.8% vs. 13.0%, P=0.008), and MALE (28.1% vs. 13.0%, P=0.021) rates than those with an NLR<8. In multivariate logistic regression, an NLR≥8 was significantly associated with all-cause (P<0.001) and cardiac-related (adjusted HR: 5.286, 95% CI: 2.075-13.47, P<0.001) mortality, and an NLR≥6 was significantly associated with MALEs (adjusted HR: 2.804, 95% CI: 1.292-6.088, P=0.009).Conclusion: CLI patients with high NLRs had higher risks of 1-year all-cause and cardiac-related mortality and MALEs. The NLR can be used for prognostic prediction in these patients.

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Neutrophil-to-lymphocyte ratio is effective prognostic indicator for post-amputation patients with critical limb ischemia

Saudi Medical Journal ◽

10.15537/smj.2017.1.15936 ◽

2017 ◽

Vol 38 (1) ◽

pp. 24-29 ◽

Cited By ~ 3

Author(s):

Qi Wang ◽

Han Liu ◽

Siqiao Sun ◽

Zhihua Cheng ◽

Yang Zhang ◽

...

Keyword(s):

Critical Limb Ischemia ◽

Limb Ischemia ◽

Prognostic Indicator ◽

Neutrophil To Lymphocyte Ratio ◽

Lymphocyte Ratio

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Associations of procalcitonin, C-reaction protein and neutrophil-to-lymphocyte ratio with mortality in hospitalized COVID-19 patients in China

Scientific Reports ◽

10.1038/s41598-020-72164-7 ◽

2020 ◽

Vol 10 (1) ◽

Cited By ~ 3

Author(s):

Jian-bo Xu ◽

Chao Xu ◽

Ru-bing Zhang ◽

Meng Wu ◽

Chang-kun Pan ◽

...

Keyword(s):

Risk Factor ◽

Retrospective Study ◽

Independent Risk Factor ◽

Neutrophil To Lymphocyte Ratio ◽

Age Group ◽

Lymphocyte Ratio ◽

Risk Of Mortality ◽

Increased Risk ◽

Increasing Risk ◽

Baseline Levels

Abstract Coronavirus disease 2019 (COVID-19) is an important and urgent threat to global health. Inflammation factors are important for COVID-19 mortality, and we aim to explore whether the baseline levels of procalcitonin (PCT), C-reaction protein (CRP) and neutrophil-to-lymphocyte ratio (NLR) are associated with an increased risk of mortality in patients with COVID-19. A retrospective study was conducted and a total of 76 patients with confirmed COVID-19 were included between January 17, 2020 to March 2, 2020, of these cases, 17 patients were dead. After adjusting covariates, PCT (≥ 0.10 ng/mL) and CRP (≥ 52.14 mg/L) exhibited independent increasing risks of mortality were used hazard ratio (HR) of 52.68 (95% confidence interval [CI]: 1.77–1571.66) and 5.47 (95% CI: 1.04–28.72), respectively. However, NRL (≥ 3.59) was not found to be an independent risk factor for death in our study. Furthermore, the elevated PCT levels were still associated with increasing risk of mortality in the old age group (age ≥ 60 y), and in the critically severe and severe patients after adjustment for complications. Thu Baseline levels of PCT and CRP have been addressed as independent predictors of mortality in patients with COVID-19.

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Abstract 728: The Neutrophil-to-lymphocyte Ratio is Associated With Amputation Free Survival in Critical Limb Ischemia

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvb.38.suppl_1.728 ◽

2018 ◽

Vol 38 (Suppl_1) ◽

Author(s):

Femke C van Rhijn-Brouwer ◽

Hendrik Gremmels ◽

Ian D van Koeverden ◽

Martin Teraa ◽

Gerard Pasterkamp ◽

...

Keyword(s):

Critical Limb Ischemia ◽

Limb Ischemia ◽

Neutrophil To Lymphocyte Ratio ◽

Free Survival ◽

Lymphocyte Ratio

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Neutrophil-to-Lymphocyte Ratio and Its Association with Critical Limb Ischemia in PAOD Patients

PLoS ONE ◽

10.1371/journal.pone.0056745 ◽

2013 ◽

Vol 8 (2) ◽

pp. e56745 ◽

Cited By ~ 30

Author(s):

Thomas Gary ◽

Martin Pichler ◽

Klara Belaj ◽

Franz Hafner ◽

Armin Gerger ◽

...

Keyword(s):

Critical Limb Ischemia ◽

Limb Ischemia ◽

Neutrophil To Lymphocyte Ratio ◽

Lymphocyte Ratio

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Impact of Baseline Neutrophil-to-Lymphocyte Ratio on Long-Term Prognosis in Patients With Atrial Fibrillation

Angiology ◽

10.1177/00033197211000495 ◽

2021 ◽

pp. 000331972110004

Author(s):

Shuang Wu ◽

Yan-min Yang ◽

Jun Zhu ◽

Jia-meng Ren ◽

Juan Wang ◽

...

Keyword(s):

Atrial Fibrillation ◽

Continuous Variable ◽

Cox Proportional Hazards ◽

Neutrophil To Lymphocyte Ratio ◽

Long Term Outcomes ◽

Lymphocyte Ratio ◽

Net Reclassification Improvement ◽

Increased Risk ◽

All Cause Mortality

We performed a retrospective analysis involving 1269 patients with atrial fibrillation (AF) to evaluate the predictive value of the neutrophil-to-lymphocyte ratio (NLR) on long-term outcomes. The primary outcomes were all-cause mortality and combined end point events (CEEs). Cox proportional hazards regression analysis and net reclassification improvement (NRI) analysis were performed. During a median follow-up of 3.32 years, 285 deaths and 376 CEEs occurred. With the elevation of the NLR, the incidence of all-cause mortality (2.77, 4.14, 6.12, and 12.18/100 person-years) and CEEs (4.19, 7.40, 8.03, and 15.22/100 person-years) significantly increased. Multivariate Cox analysis indicated that the highest NLR quartile was independently associated with the incidence of all-cause mortality (hazard ratio [HR] = 1.77, 95% CI: 1.19-2.65) and CEEs (HR = 1.66, 95% CI: 1.18-2.33). When the NLR was analyzed as a continuous variable, a 1-unit increment in log NLR was related to 134% increased risk of all-cause mortality and 119% increased risk of CEEs. Net reclassification improvement analysis revealed that NLR significantly improved risk stratification for all-cause death and CEEs by 15.0% and 9.6%, respectively. Neutrophil-to-lymphocyte ratio could be an independent predictor of long-term outcomes in patients with AF.

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Neutrophil-to-Lymphocyte Ratio and Symptomatic Hemorrhagic Transformation in Ischemic Stroke Patients Undergoing Revascularization

Brain Sciences ◽

10.3390/brainsci10110771 ◽

2020 ◽

Vol 10 (11) ◽

pp. 771

Author(s):

Milena Świtońska ◽

Natalia Piekuś-Słomka ◽

Artur Słomka ◽

Paweł Sokal ◽

Ewa Żekanowska ◽

...

Keyword(s):

Ischemic Stroke ◽

Multivariable Analysis ◽

Area Under The Curve ◽

Intravenous Thrombolysis ◽

Hemorrhagic Transformation ◽

Neutrophil To Lymphocyte Ratio ◽

Study Endpoint ◽

Stroke Treatment ◽

Lymphocyte Ratio ◽

Increased Risk

Objectives: Symptomatic hemorrhagic transformation (sHT) is a life-threatening complication of acute ischemic stroke (AIS). The early identification of the patients at increased risk of sHT can have clinically relevant implications. The aim of this study was to explore the validity and accuracy of the neutrophil-to-lymphocyte ratio (NLR) in predicting sHT in patients with AIS undergoing revascularization. Methods: Consecutive patients hospitalized for AIS who underwent intravenous thrombolysis, mechanical thrombectomy or both were identified. The NLR values were estimated at admission. The study endpoint was the occurrence of sHT within 24 h from stroke treatment. Results: Fifty-one patients with AIS were included, with a median age of 67 (interquartile range, 55–78) years. sHT occurred in 10 (19.6%) patients. Patients who developed sHT had higher NLR at admission. NLR was an independent predictor of sHT and showed good discriminatory power (area under the curve 0.81). In a multivariable analysis, NLR and systolic blood pressure were independently associated with sHT. Conclusions: NLR at admission can accurately predict sHT in patients with AIS undergoing revascularization.

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