Asthma and Severity of Blood Stream Infection Caused by Escherichia coli: A Population-Based Study

2012 ◽  
Vol 129 (2) ◽  
pp. AB165
Author(s):  
H.J. Yang ◽  
J. Lee ◽  
L.M. Baddour ◽  
M.N. Al-Hasan ◽  
B.P. Yawn ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Blood Stream Infection ◽  
Blood Stream ◽  
Population Based ◽  
Population Based Study

Asthma and Risk of Community-Acquired Blood Stream Infection Caused by Escherichia Coli: A Population-Based Case-Control Study

2013 ◽  
Vol 131 (2) ◽  
pp. AB152
Author(s):  
Hyeon Jong Jong Yang ◽  
Duk Won Bang ◽  
Eell Ryoo ◽  
Larry Baddour ◽  
Majdi Al-Hasan ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Case Control Study ◽  
Blood Stream Infection ◽  
Blood Stream ◽  
Population Based ◽  
Case Control ◽  
Control Study

scholarly journals 701. Blood Stream Infection And Risk Of Endocarditis Following Cardiac Valve Repair: A Population-Based Study

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S401-S401
Author(s):  
Jack McHugh ◽  
Talha Khawaja ◽  
Larry M Baddour ◽  
Larry M Baddour ◽  
Juan Crestanello ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Stream Infection ◽  
Subsequent Development ◽  
Bloodstream Infections ◽  
Population Based ◽  
Cardiac Valve ◽  
Valve Repair ◽  
Population Based Study ◽  
Increased Risk ◽  
One Year

Abstract Background Bloodstream infections (BSIs) confer an increased risk of infective endocarditis (IE) in patients with a prosthetic cardiac valve. This relationship is less well established in patients undergoing valve repair. We conducted a retrospective population-based study to determine the incidence of BSIs following valve repair and identify risk factors associated with the development of IE. Methods The Rochester Epidemiology Project (REP) data linkage system was used to identify all persons who underwent valve repair in a 7-county region in Southeastern Minnesota between January 1, 2010 and December 31, 2018. Medical records were screened for the development of a BSI from time of procedure until May 15, 2020. Patients were classified as having BSI only, BSI with IE at outset, or BSI with subsequent development of new IE. IE at outset was defined as cases where IE was diagnosed at the time of initial positive blood culture. Results A total of 387 patients underwent valve repair surgery. A total of 31 (8%) patients subsequently developed a BSI, 4% within one year of surgery. Seventeen patients underwent mitral repair with annuloplasty, 9 underwent tricuspid annuloplasty, and 5 had concurrent repairs. Median time to the development of BSI was 338 days. Of the 31 patients with BSI, 4 (13%) had BSI with IE at outset. No patients developed IE subsequent to BSI, Enterococcus spp. was responsible for 3 cases of IE, and MSSA for 1. All cases occurred within one year of surgery. Given the low incidence, statistical analysis of associated risk factors for IE was not feasible. All patients with BSI and IE at outset, however, died by the end of the study period, versus 11/27 in the BSI only group. Conclusion Incidence of BSIs was higher in patients undergoing cardiac valve repair than in the general population. The incidence of IE with a BSI was 13%, which is lower than what has been previously published. It is notable that all cases of IE occurred within one year of surgery. Recognizing that endothelialization of device surfaces occurs, it is tempting to speculate that the risk of IE may be time dependent and may decline over time. Subsequent investigation of this theory is underway. Disclosures Larry M. Baddour, MD, Boston Scientific (Consultant)

scholarly journals National trend of blood-stream infection attributable deaths caused by Staphylococcus aureus and Escherichia coli in Japan

2020 ◽  
Vol 26 (4) ◽  
pp. 367-371 ◽  
Author(s):  
Shinya Tsuzuki ◽  
Nobuaki Matsunaga ◽  
Koji Yahara ◽  
Yoshiaki Gu ◽  
Kayoko Hayakawa ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Blood Stream Infection ◽  
Blood Stream ◽  
National Trend

Risk factors for blood stream infections in multiple myeloma: A population-based study of 1154 patients in Denmark

2018 ◽  
Vol 101 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Rasmus Sørrig ◽  
Tobias W. Klausen ◽  
Morten Salomo ◽  
Annette Vangsted ◽  
Peter Gimsing
Keyword(s):  
Risk Factors ◽  
Multiple Myeloma ◽  
Blood Stream ◽  
Population Based ◽  
Blood Stream Infections ◽  
Population Based Study

Infections in Neonates and Young Children

2019 ◽  
Author(s):  
Michael Millar ◽  
Steve Kempley
Keyword(s):  
Escherichia Coli ◽  
Preterm Birth ◽  
Chlamydia Trachomatis ◽  
Young Children ◽  
Respiratory Distress ◽  
Blood Stream Infection ◽  
Neonatal Infection ◽  
Blood Stream ◽  
Ascending Infection ◽  
Early Sepsis

This chapter covers infections in neonates and young children. In this chapter the term ‘young children’ indicates children under two years of age. For information on congenital infections interested readers are referred to Chapter 37. Early neonatal infection is variably defined as infection presenting up to a week after birth, but most infections present in the first seventy-two hours. Microbial invasion of the chorio-amniotic membranes or uterine cavity occur in a significant proportion of pregnancies before rupture of membranes (> 50% with preterm birth before thirty weeks gestation, 10% with term delivery), and in the majority of those with prolonged rupture of membranes (> 24 hours). It is likely that the majority of cases of early sepsis arise through ascending infection of the uterus (through the cervical canal). Ascending infection may be important in the pathogenesis of preterm birth and is more common in infants born preterm. Group B Streptococci (GBS) (Streptococcus agalactiae) and Escherichia coli are the most common agents of early neonatal infection. Infection with Listeria monocytogenes probably arises following ingestion of contaminated food by the mother, blood stream infection, and transplacental spread. Early infection with GBS usually presents with respiratory distress and can be difficult to differentiate from respiratory distress associated with other causes, particularly prematurity. The incidence of GBS blood stream infection in England and Wales has been 0.3–0.45/ 1000 live births over the last five years. Maternal genital herpes simplex infection can spread to the newborn infant and cause a wide range of serious clinical presentations, with skin, systemic, and central nervous system involvement. Maternal infection with Neisseria gonorrhoea or Chlamydia trachomatis can also infect the infant. Either can cause conjunctivitis which can sometimes be of sufficient severity to cause substantial damage to the eyes. Gonococcal conjunctivitis usually presents in the first few days of life. Infection with Chlamydia trachomatis (conjunctivitis or pneumonitis) tends to present later. Traditionally, penicillin and an aminoglycoside have been used to treat infants with suspected early sepsis (to cover GBS and Escherichia coli). Newborn infants are often empirically treated because it can be difficult to differentiate early bacterial sepsis from respiratory distress associated with prematurity, and death may ensue rapidly if the infection is not treated.

scholarly journals Genomic Characterization of MDR Escherichia coli Harboring blaOXA-48 on the IncL/M-type Plasmid Isolated from Blood Stream Infection

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
S. Alousi ◽  
T. Salloum ◽  
H. Arabaghian ◽  
G. M. Matar ◽  
G. F. Araj ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Blood Stream Infection ◽  
Genomic Analysis ◽  
Blood Stream ◽  
Population Movements ◽  
E Coli ◽  
Resistance Determinants ◽  
Genomic Characterization ◽  
Hospital Acquired

Escherichia coli is responsible for a wide variety of community and hospital acquired extraintestinal infections, and the emergence of ESBL resistant isolates is a major clinical concern. In this study, we characterized the genomic attributes of an OXA-48 and CTX-M-3 producing E. coli EC-IMP153. Whole-genome initial assembly produced 146 contigs with a combined 5,504,170 bp in size and a G+C content of 50.5%. wgSNPs-based phylogenetic comparison with 36 publically available genomes was also performed. Comprehensive genomic analysis showed that EC-IMP153 belonged to sequence type ST-405 and harbored several resistance determinants including the β-lactam resistance genes blaOXA-48, blaCTX-M-3, blaTEM-1B, blaOXA-1, and blaCMY-70, aminoglycoside fyuA and aac(3)IId, tetracycline tet(A) and tet(R), and fluoroquinolone gyrA, parC, and mfd resistance determinants. Plasmids with the following incompatibility groups were detected in silico and confirmed using PBRT: IncI1-α, IncL, IncW, Col (BS512), and IncF. To our knowledge this is the first in-depth genomic analysis of an OXA-48 producing E. coli ST-405 isolated from a patient in Lebanon and linked to a blood stream infection. Continuous monitoring is necessary to better understand the continued diffusion of such pathogens, especially in view of the population movements triggered by unrest in the Middle East.

scholarly journals Potential impact of novel diagnostics and treatments on the burden of antibiotic resistant in Escherichia coli

2016 ◽  
Author(s):  
Pierre Nouvellet ◽  
J.V. Robotham ◽  
N.R. Naylor ◽  
N. Woodford ◽  
Neil M. Ferguson
Keyword(s):  
Escherichia Coli ◽  
Blood Stream Infection ◽  
Blood Stream ◽  
Case Scenario ◽  
Worst Case ◽  
Blood Stream Infections ◽  
E Coli ◽  
Hospital Bed ◽  
The Impact ◽  
Excess Deaths

AbstractThe rising threat of antibiotic resistance in Europe and beyond is of increasing concern and is prompting renewed effort to better understand and mitigate their impact. Escherichia Coli blood stream infections are a more major concern in Europe given their incidence and severe associated outcomes. Additionally the level of 3rd generation cephalosporins and carbapenems resistance among those bacteraemia has significantly increased, limiting available treatment options. We estimated the current burden associated with E. coli blood stream infections in Europe at 17,000 (95%CI [8,000; 30,000]) excess deaths and 960,000 (95%CI [600,000; 1,450,000]) extra hospital bed days. From those, the contribution due to 3rd generation cephalosporins and carbapenems resistant strains reached 6,000 (95%CI [2,000; 12,000]) excess deaths, and 200,000 (95%CI [76,000; 420,000]) extra hospital bed stay. In the worst case scenario, we estimated the burden of E. coli blood stream infection in 2026 could increase over 4-fold, mostly resulting from an increase in the level of resistance rather than an increase in the incidence of blood stream infections. Finally, we estimated that the impact of combined novel diagnostics and treatments could substantially reduce the excess mortality by 18.5% to 55.5%, and length of stay by 13.2% to 75.6%.

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