A unique emotional processing profile of euthymic bipolar disorder? A critical review

2013 ◽  
Vol 146 (3) ◽  
pp. 295-309 ◽  
Author(s):  
L. Mercer ◽  
R. Becerra
Keyword(s):  
Bipolar Disorder ◽  
Critical Review ◽  
Emotional Processing

Current issues in bipolar disorder: A critical review

2007 ◽  
Vol 17 (11) ◽  
pp. 687-695 ◽  
Author(s):  
Pierre Oswald ◽  
Daniel Souery ◽  
Siegfried Kasper ◽  
Yves Lecrubier ◽  
Stuart Montgomery ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Critical Review

scholarly journals Gray matter volume covariance networks are associated with altered emotional processing in bipolar disorder: a source-based morphometry study

2021 ◽  
Author(s):  
Alessandro Miola ◽  
Nicolò Trevisan ◽  
Arcangelo Merola ◽  
Francesco Folena Comini ◽  
Daniele Olivo ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Gray Matter ◽  
Emotional Processing ◽  
Gray Matter Volume ◽  
Occipital Cortex ◽  
Type I ◽  
Matter Volume ◽  
Visuospatial Processing ◽  
Neural Signature ◽  
Structural Networks

AbstractWidespread regional gray matter volume (GMV) alterations have been reported in bipolar disorder (BD). Structural networks, which are thought to better reflect the complex multivariate organization of the brain, and their clinical and psychological function have not been investigated yet in BD. 24 patients with BD type-I (BD-I), and 30 with BD type-II (BD-II), and 45 controls underwent MRI scan. Voxel-based morphometry and source-based morphometry (SBM) were performed to extract structural covariation patterns of GMV. SBM components associated with morphometric differences were compared among diagnoses. Executive function and emotional processing correlated with morphometric characteristics. Compared to controls, BD-I showed reduced GMV in the temporo-insular-parieto-occipital cortex and in the culmen. An SBM component spanning the prefrontal-temporal-occipital network exhibited significantly lower GMV in BD-I compared to controls, but not between the other groups. The structural network covariance in BD-I was associated with the number of previous manic episodes and with worse executive performance. Compared to BD-II, BD-I showed a loss of GMV in the temporal-occipital regions, and this was correlated with impaired emotional processing. Altered prefrontal-temporal-occipital network structure could reflect a neural signature associated with visuospatial processing and problem-solving impairments as well as emotional processing and illness severity in BD-I.

Treatment guidelines for bipolar disorder: A critical review

2005 ◽  
Vol 86 (1) ◽  
pp. 1-10 ◽  
Author(s):  
K.N. Fountoulakis ◽  
E. Vieta ◽  
J. Sanchez-Moreno ◽  
S.G. Kaprinis ◽  
J.M. Goikolea ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Critical Review ◽  
Treatment Guidelines

Perceived Stress and Salience Network Functioning During Emotional Processing in Young Adults With Bipolar Disorder

2020 ◽  
Vol 87 (9) ◽  
pp. S209-S210
Author(s):  
Dylan Kirsch ◽  
Valeria Tretyak ◽  
Vanessa Le ◽  
Stephen Strakowski ◽  
Elizabeth Lippard
Keyword(s):  
Bipolar Disorder ◽  
Young Adults ◽  
Perceived Stress ◽  
Emotional Processing ◽  
Salience Network

scholarly journals The impact of the Val158Met catechol-O-methyltransferase genotype on neural correlates of sad facial affect processing in patients with bipolar disorder and their relatives

2010 ◽  
Vol 41 (4) ◽  
pp. 779-788 ◽  
Author(s):  
G. Lelli-Chiesa ◽  
M. J. Kempton ◽  
J. Jogia ◽  
R. Tatarelli ◽  
P. Girardi ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Anxiety Disorders ◽  
Psychiatric Diagnosis ◽  
Emotional Processing ◽  
Disease Risk ◽  
Family Members ◽  
Facial Affect ◽  
Healthy Controls ◽  
The Impact ◽  
Affect Processing

BackgroundThe Met allele of the catechol-O-methyltransferase (COMT) valine-to-methionine (Val158Met) polymorphism is known to affect dopamine-dependent affective regulation within amygdala–prefrontal cortical (PFC) networks. It is also thought to increase the risk of a number of disorders characterized by affective morbidity including bipolar disorder (BD), major depressive disorder (MDD) and anxiety disorders. The disease risk conferred is small, suggesting that this polymorphism represents a modifier locus. Therefore our aim was to investigate how the COMT Val158Met may contribute to phenotypic variation in clinical diagnosis using sad facial affect processing as a probe for its neural action.MethodWe employed functional magnetic resonance imaging to measure activation in the amygdala, ventromedial PFC (vmPFC) and ventrolateral PFC (vlPFC) during sad facial affect processing in family members with BD (n=40), MDD and anxiety disorders (n=22) or no psychiatric diagnosis (n=25) and 50 healthy controls.ResultsIrrespective of clinical phenotype, the Val158 allele was associated with greater amygdala activation and the Met158 allele with greater signal change in the vmPFC and vlPFC. Signal changes in the amygdala and vmPFC were not associated with disease expression. However, in the right vlPFC the Met158 allele was associated with greater activation in all family members with affective morbidity compared with relatives without a psychiatric diagnosis and healthy controls.ConclusionsOur results suggest that the COMT Val158Met polymorphism has a pleiotropic effect within the neural networks subserving emotional processing. Furthermore the Met158 allele further reduces cortical efficiency in the vlPFC in individuals with affective morbidity.

scholarly journals Neuropsychology of bipolar disorder

2001 ◽  
Vol 178 (S41) ◽  
pp. s120-s127 ◽  
Author(s):  
F. C. Murphy ◽  
B. J. Sahakian
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Impairment ◽  
Cognitive Processing ◽  
Neuropsychological Tests ◽  
Emotional Processing ◽  
Group Differences ◽  
Affective Meaning ◽  
Future Studies ◽  
Affective Components ◽  
The Relationship

BackgroundAlthough the presence of wide-ranging neuropsychological deficits in individuals with major depression is well established, few studies have investigated the nature of cognitive impairment in patients with bipolar disorder.AimsTo review research of the neuropsychology of bipolar disorder, with special attention to the relationship between mood and cognitive functioning.MethodLiterature review.ResultsFindings generally demonstrate mania-related impairments on conventional neuropsychological tests, with direct comparisons of patients with mania and patients with depression failing to find group differences. More recent work has sought to differentiate these disorders by employing tasks with affective components. This research has demonstrated biases for processing positive and negative stimuli in patients with mania and depression, respectively.ConclusionsFuture studies, employing tasks that require cognitive and emotional processing, should improve our understanding of the deficits observed in depression and mania. Neuroimaging studies of the neural regions that underlie cognitive processing of affective meaning suggest that the medial and orbitofrontal prefrontal cortex may be particularly involved.

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