The potential impact of biochemical mediators on telomere attrition in major depressive disorder and implications for future study designs: A narrative review

2018 ◽  
Vol 225 ◽  
pp. 630-646 ◽  
Author(s):  
Andrei Manoliu ◽  
Oliver G. Bosch ◽  
Janis Brakowski ◽  
Annette B. Brühl ◽  
Erich Seifritz
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Future Study ◽  
Narrative Review ◽  
Major Depressive ◽  
Telomere Attrition ◽  
Potential Impact ◽  
Study Designs

Depression Among Athletes and the Potential Impact on Performance

2018 ◽  
Author(s):  
Zella Moore ◽  
Jamie Leboff ◽  
Kehana Bonagura
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Well Being ◽  
Performance Outcomes ◽  
Major Depressive ◽  
Bipolar Ii Disorder ◽  
Bipolar Ii ◽  
Decision Making Processes ◽  
Potential Impact ◽  
Multiple Domains

Major depressive disorder, dysthymia, and bipolar disorder are very common diagnoses seen among athletes, and they are serious conditions that can be debilitating if not properly addressed. These disorders warrant careful attention because they can adversely affect multiple domains of an athlete’s life, including athletic motivation, performance outcomes, interpersonal well-being, health, and overall daily functioning. Key foci include the prevalence of, clinical characteristics of, causes of, and risk factors for major depressive disorder, persistent depressive disorder/dysthymia, bipolar I disorder, and bipolar II disorder. Sport psychologists should integrate such important information into their overall case conceptualization and decision-making processes to ensure that athletes and performers at risk for, or struggling with, such mental health concerns receive the most effective, efficient, and timely care possible.

Effect of yoga and meditation on accelerated cellular aging in major depressive disorder patients

2017 ◽  
Vol 41 (S1) ◽  
pp. S543-S543
Author(s):  
T. Madhuri ◽  
R. Dada ◽  
R. Sagar
Keyword(s):  
Dna Damage ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Peripheral Blood ◽  
Healthy Subjects ◽  
Rating Scale ◽  
Cellular Aging ◽  
Sirtuin 1 ◽  
Major Depressive ◽  
Telomere Attrition

IntroductionAccelerated aging is associated with major depressive disorder (MDD) and studies of yoga and meditation based lifestyle intervention (YMLI) on biomarkers of cellular aging are lacking.Aim and objectivesTo investigate the peripheral blood biomarkers of cellular aging in MDD patients after short term YMLI. Biomarkers include DNA damage, oxidative stress (OS), telomere attrition, and nutrition sensing assessed respectively by 8-hydroxy 2’- deoxyguanosine (8-OHdG); reactive oxygen species (ROS) and total antioxidant capacity (TAC); telomere length and telomerase activity; and sirtuin-1.MethodsWe consecutively enrolled 33 MDD patients and 40 healthy subjects; 30 MDD patients were followed up with 12- week YMLI. Biomarkers of cellular aging in peripheral blood were measured with assay kits. All patients were evaluated by examining the correlation between cellular aging markers and Montgomery–Asberg Depression Rating Scale (MADRS) scores.ResultsThe levels of DNA damage, OS, and telomere attrition in MDD patients were significantly higher than healthy subjects (all P = 0.005). The MADRS scores had a significantly positive association with 8-OHdG and ROS levels and negative association with TAC, telomerase and sirtuin-1 levels (all P < 0.01).ConclusionsPeripheral blood biomarker levels in our results suggest significant cellular aging in MDD patients compared to healthy subjects. There was strong correlation between the changes in biomarkers of cellular aging and clinical improvement in MDD. Our study is the first to show significant increase in sirtuin-1 levels in MDD patients after yoga and meditation. Therefore, biomarkers of cellular aging might be indicators of MDD severity and clinical remission after YMLI.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Tobacco smoking as a risk factor for major depressive disorder: population-based study

2008 ◽  
Vol 193 (4) ◽  
pp. 322-326 ◽  
Author(s):  
Julie A. Pasco ◽  
Lana J. Williams ◽  
Felice N. Jacka ◽  
Felicity Ng ◽  
Margaret J. Henry ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Risk Factor ◽  
Depressive Disorder ◽  
De Novo ◽  
Population Based ◽  
Major Depressive ◽  
Cross Sectional ◽  
History Of ◽  
Study Designs

BackgroundSmoking is disproportionately prevalent among people with psychiatric illness.AimsTo investigate smoking as a risk factor for major depressive disorder.MethodA population-based sample of women was studied using case–control and retrospective cohort study designs. Exposure to smoking was self-reported, and major depressive disorder diagnosed using the Structured Clinical Interview for DSM–IV–TR (SCID–I/NP).ResultsAmong 165 people with major depressive disorder and 806 controls, smoking was associated with increased odds for major depressive disorder (age-adjusted odds ratio (OR)=1.46, 95% CI 1.03–2.07). Compared with non-smokers, odds for major depressive disorder more than doubled for heavy smokers (>20 cigarettes/day). Among 671 women with no history of major depressive disorder at baseline, 13 of 87 smokers and 38 of 584 non-smokers developedde novomajor depressive disorder during a decade of follow-up. Smoking increased major depressive disorder risk by 93% (hazard ratio (HR)=1.93, 95% CI 1.02–3.69); this was not explained by physical activity or alcohol consumption.ConclusionsEvidence from cross-sectional and longitudinal data suggests that smoking increases the risk of major depressive disorder in women.

scholarly journals Is There an Association Between Migraine and Major Depressive Disorder? A Narrative Review

Cureus ◽  
2020 ◽  
Author(s):  
Saira Jahangir ◽  
Dennis Adjepong ◽  
Hieder A Al-Shami ◽  
Bilal Haider Malik
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Narrative Review ◽  
Major Depressive

Understanding bereavement-related depression: the polemical journey of DSM-5

2014 ◽  
Vol 31 (3) ◽  
pp. 195-202
Author(s):  
I. Ibrahim
Keyword(s):  
Major Depressive Disorder ◽  
Mental Disorders ◽  
Depressive Disorder ◽  
Narrative Review ◽  
Type Result ◽  
Major Depressive ◽  
Exclusion Criteria ◽  
Dsm 5 ◽  
Dsm Iv

ObjectiveThis paper will bring you on a polemical journey to understand the issues related in conceptualizing bereavement-related depression.MethodA critical narrative review was carried out to evaluate arguments and controversies surrounding DSM-IV classifications of bereavement exclusion for the diagnosis of major depressive disorder (MDD).ResultAvailable studies that are associated with bereavement exclusion criteria, the open trials and treatments with the implications of such conceptualizations and the current removal of the bereavement exclusion from MDD in DSM-5 were addressed.ConclusionThe review highlights the never-ending polemical journey of conceptualizing any mental disorders, bereavement-related depression included.

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