Sex differences in the transcription of monoamine transporters in major depression.

2021 ◽  
Author(s):  
Greg C. Bristow ◽  
Tory Eisenlohr-Moul ◽  
Krista Lotesto ◽  
Monsheel S. Sodhi
Keyword(s):  
Sex Differences ◽  
Major Depression ◽  
Monoamine Transporters

Geschlechtsunterschiede in Glucocorticoidkonzentrationen und Entzündungsparametern im Zusammenhang mit Depression

2020 ◽  
Vol 39 (04) ◽  
pp. 222-237
Author(s):  
Lena Schneider ◽  
Andreas Walther
Keyword(s):  
Sex Differences ◽  
Major Depression ◽  
Hpa Axis ◽  
Web Of Science ◽  
Tnf Alpha ◽  
Mesh Terms

ZusammenfassungHintergrund: Frauen erkranken fast doppelt so häufig wie Männer an einer Major Depression. Eine Hyperaktivität der Hypothalamus-Hypophysen-Nebennierenrinden-Achse (HHNA) und eine chronisch niedrig-gradige Inflammation sind 2 der konsistentesten biologischen Befunde bei schweren Depressionen. Inwiefern diese Parameter für die Existenz von Geschlechtsunterschieden bei Depression eine Rolle spielen, ist noch unzureichend untersucht worden. Methoden: Es wurde eine systematische Literaturrecherche mittels der elektronischen Fachdatenbanken (PubMed, Web of Science, PsycARTICLES) durchgeführt. Die Suche umfasste alle englischsprachigen Artikel, die bis zum 29. Juni 2019 aufgenommen wurden. Als MeSH terms wurden depression, sex differences, inflammation, hpa axis, mit Zusätzen wie cortisol, crp, IL-6, TNF-alpha, dex/crh oder tsst verwendet. Ergebnisse: Insgesamt konnten 62 Primärstudien mit einem Total von 91318 Probanden (52 % Frauen) eingeschlossen werden. Basale Glucocorticoidkonzentrationen scheinen für beide Geschlechter tendenziell positiv mit dem Vorliegen oder der Schwere einer Depressionssymptomatik assoziiert zu sein. Konsistente Geschlechtsunterschiede konnten für die Cortisolreaktion auf einen Stressor sowie für Entzündungsmarker identifiziert werden. Fazit: Geschlechtsunterschiede in der Neurobiologie der Depression sind identifizierbar und geben Anlass für geschlechtsspezifische Untersuchungen der Pathophysiologie von Depressionen und deren geschlechtsspezifischer Behandlungen.

Sex similarities and differences in risk factors for recurrence of major depression

2017 ◽  
Vol 48 (10) ◽  
pp. 1685-1693 ◽  
Author(s):  
Hanna M. van Loo ◽  
Steven H. Aggen ◽  
Charles O. Gardner ◽  
Kenneth S. Kendler
Keyword(s):  
Risk Factors ◽  
Sex Differences ◽  
Family History ◽  
Major Depression ◽  
Prediction Models ◽  
Population Sample ◽  
Disease Onset ◽  
Risk Factors For Recurrence ◽  
Males And Females ◽  
The Impact

AbstractBackgroundMajor depression (MD) occurs about twice as often in women as in men, but it is unclear whether sex differences subsist after disease onset. This study aims to elucidate potential sex differences in rates and risk factors for MD recurrence, in order to improve prediction of course of illness and understanding of its underlying mechanisms.MethodsWe used prospective data from a general population sample (n = 653) that experienced a recent episode of MD. A diverse set of potential risk factors for recurrence of MD was analyzed using Cox models subject to elastic net regularization for males and females separately. Accuracy of the prediction models was tested in same-sex and opposite-sex test data. Additionally, interactions between sex and each of the risk factors were investigated to identify potential sex differences.ResultsRecurrence rates and the impact of most risk factors were similar for men and women. For both sexes, prediction models were highly multifactorial including risk factors such as comorbid anxiety, early traumas, and family history. Some subtle sex differences were detected: for men, prediction models included more risk factors concerning characteristics of the depressive episode and family history of MD and generalized anxiety, whereas for women, models included more risk factors concerning early and recent adverse life events and socioeconomic problems.ConclusionsNo prominent sex differences in risk factors for recurrence of MD were found, potentially indicating similar disease maintaining mechanisms for both sexes. Course of MD is a multifactorial phenomenon for both males and females.

scholarly journals Sex Differences in Clinical Predictors of Suicidal Acts After Major Depression: A Prospective Study

2007 ◽  
Vol 164 (1) ◽  
pp. 134-141 ◽  
Author(s):  
Maria A. Oquendo ◽  
Mary E. Bongiovi-Garcia ◽  
Hanga Galfalvy ◽  
Pablo H. Goldberg ◽  
Michael F. Grunebaum ◽  
...  
Keyword(s):  
Sex Differences ◽  
Major Depression ◽  
Prospective Study ◽  
Clinical Predictors ◽  
A Prospective Study

scholarly journals Sex differences in glutamate receptor gene expression in major depression and suicide

2015 ◽  
Vol 20 (9) ◽  
pp. 1057-1068 ◽  
Author(s):  
A L Gray ◽  
T M Hyde ◽  
A Deep-Soboslay ◽  
J E Kleinman ◽  
M S Sodhi
Keyword(s):  
Gene Expression ◽  
Sex Differences ◽  
Major Depression ◽  
Glutamate Receptor ◽  
Receptor Gene ◽  
Receptor Gene Expression

scholarly journals Suicidal Ideation in Major Depression: Sex Differences and Impact of Comorbid Anxiety

2000 ◽  
Vol 45 (9) ◽  
pp. 822-826 ◽  
Author(s):  
Ayal Schaffer ◽  
Anthony J Levitt ◽  
R Michael Bagby ◽  
Sidney H Kennedy ◽  
Robert D Levitan ◽  
...  
Keyword(s):  
Sex Differences ◽  
Suicidal Ideation ◽  
Major Depression ◽  
Comorbid Anxiety

Ethnic and Sex Differences in Suicide Rates Relative to Major Depression in the United States

2001 ◽  
Vol 158 (10) ◽  
pp. 1652-1658 ◽  
Author(s):  
Maria A. Oquendo ◽  
Steven P. Ellis ◽  
Steven Greenwald ◽  
Kevin M. Malone ◽  
Myrna M. Weissman ◽  
...  
Keyword(s):  
United States ◽  
Sex Differences ◽  
Major Depression ◽  
The United States ◽  
Suicide Rates

Childhood parental loss and risk for first-onset of major depression and alcohol dependence: the time-decay of risk and sex differences

2002 ◽  
Vol 32 (7) ◽  
pp. 1187-1194 ◽  
Author(s):  
K. S. KENDLER ◽  
K. SHETH ◽  
C. O. GARDNER ◽  
C. A. PRESCOTT
Keyword(s):  
Sex Differences ◽  
Major Depression ◽  
Alcohol Dependence ◽  
Time Course ◽  
Conditional Logistic Regression ◽  
Population Based ◽  
Parental Loss ◽  
Proportional Hazard ◽  
Increased Risk ◽  
The Impact

Background. Whereas a number of studies have suggested that parental loss is associated with increased risk for major depression (MD), much less is known about possible gender differences, diagnostic specificity and the time course of the impact of loss.Method. First-onsets for MD and alcohol dependence (AD) were assessed at personal interviews in 5070 twins from same-sex (SS) and 2118 from opposite-sex (OS) twin pairs ascertained from a population-based registry. Cox Proportional Hazard (PH) and Non-Proportional Hazard (NPH) models, examining first onsets of MD and AD, were used with twins from SS pairs and conditional logistic regression for OS pairs. Parent–child separations prior to age 17 were divided into death and separation from other causes.Results. The PH assumptions of constant increased risk were rejected for the impact of loss on risk for MD but not for AD. NPH models found significantly increased risk for MD after both death and separation with the risk lasting much longer for separations. For AD, the PH model found significantly increased risk after parental separation but not death. In both SS and OS twin pairs, no sex differences were seen in the impact of parental loss on risk for MD whereas the association between separation and risk for AD was significantly stronger in females than in males.Conclusion. Consistent sex differences in the association with parental loss were seen for AD but not MD. The analysis of the time-course of increased risk after loss suggests three different patterns which may reflect different relationships: parental death and MD (return to baseline within ∼12 years), separation and MD (return to baseline within ∼30 years) and separation and AD (no change in risk over time).

scholarly journals Erratum: Sex differences in glutamate receptor gene expression in major depression and suicide

2015 ◽  
Vol 20 (9) ◽  
pp. 1139-1139 ◽  
Author(s):  
A L Gray ◽  
T M Hyde ◽  
A Deep-Soboslay ◽  
J E Kleinman ◽  
M S Sodhi
Keyword(s):  
Gene Expression ◽  
Sex Differences ◽  
Major Depression ◽  
Glutamate Receptor ◽  
Receptor Gene ◽  
Receptor Gene Expression
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