Sex similarities and differences in risk factors for recurrence of major depression

2017 ◽  
Vol 48 (10) ◽  
pp. 1685-1693 ◽  
Author(s):  
Hanna M. van Loo ◽  
Steven H. Aggen ◽  
Charles O. Gardner ◽  
Kenneth S. Kendler
Keyword(s):  
Risk Factors ◽  
Sex Differences ◽  
Family History ◽  
Major Depression ◽  
Prediction Models ◽  
Population Sample ◽  
Disease Onset ◽  
Risk Factors For Recurrence ◽  
Males And Females ◽  
The Impact

AbstractBackgroundMajor depression (MD) occurs about twice as often in women as in men, but it is unclear whether sex differences subsist after disease onset. This study aims to elucidate potential sex differences in rates and risk factors for MD recurrence, in order to improve prediction of course of illness and understanding of its underlying mechanisms.MethodsWe used prospective data from a general population sample (n = 653) that experienced a recent episode of MD. A diverse set of potential risk factors for recurrence of MD was analyzed using Cox models subject to elastic net regularization for males and females separately. Accuracy of the prediction models was tested in same-sex and opposite-sex test data. Additionally, interactions between sex and each of the risk factors were investigated to identify potential sex differences.ResultsRecurrence rates and the impact of most risk factors were similar for men and women. For both sexes, prediction models were highly multifactorial including risk factors such as comorbid anxiety, early traumas, and family history. Some subtle sex differences were detected: for men, prediction models included more risk factors concerning characteristics of the depressive episode and family history of MD and generalized anxiety, whereas for women, models included more risk factors concerning early and recent adverse life events and socioeconomic problems.ConclusionsNo prominent sex differences in risk factors for recurrence of MD were found, potentially indicating similar disease maintaining mechanisms for both sexes. Course of MD is a multifactorial phenomenon for both males and females.

Sex differences in genetic and environmental risk factors for irrational fears and phobias

2002 ◽  
Vol 32 (2) ◽  
pp. 209-217 ◽  
Author(s):  
K. S. KENDLER ◽  
K. C. JACOBSON ◽  
J. MYERS ◽  
C. A. PRESCOTT
Keyword(s):  
Risk Factors ◽  
Sex Differences ◽  
Genetic Risk ◽  
Threshold Model ◽  
Twin Studies ◽  
Genetic Effects ◽  
Males And Females ◽  
The Impact ◽  
Best Fit ◽  
Twin Resemblance

Background. For irrational fears and their associated phobias, epidemiological studies suggest sex differences in prevalence and twin studies report significant genetic effects. How does sex impact on the familial transmission of liability to fears and phobias?Methods. In personal interviews with over 3000 complete pairs (of whom 1058 were opposite-sex dizygotic pairs), ascertained from a population-based registry, we assessed the lifetime prevalence of five phobias and their associated irrational fears analysed using a multiple threshold model. Twin resemblance was assessed by polychoric correlations and biometrical model-fitting incorporating sex-specific effects.Results. For agoraphobia, situational and blood/injury fear/phobia, the best fit model suggested equal heritability in males and females and genetic correlations between the sexes of less than +0·50. For animal fear/phobias by contrast, the best fit model suggested equal heritability in males and females and a genetic correlation of unity. No evidence was found for an impact of family environment on liability to these fears or phobias. For social phobias, twin resemblance in males was explained by genetic factors and in females by familial–environmental factors.Conclusion. The impact of sex on genetic risk may differ meaningfully across phobia subtypes. Sex-specific genetic risk factors may exist for agoraphobia, social, situational and blood-injury phobias but not for animal fear/phobia. These results should be interpreted in the context of the limited power of twin studies, even with large sample sizes, to resolve sex-specific genetic effects.

scholarly journals Birth desires and intentions of women diagnosed with a meningioma

2015 ◽  
Vol 122 (5) ◽  
pp. 1151-1156 ◽  
Author(s):  
Michelle A. Owens ◽  
Benjamin M. Craig ◽  
Kathleen M. Egan ◽  
Damon R. Reed
Keyword(s):  
Risk Factors ◽  
General Population ◽  
Potential Risk ◽  
Online Survey ◽  
Common Factor ◽  
Reproductive Decisions ◽  
Childbearing Age ◽  
Potential Risk Factors ◽  
Risk Factors For Recurrence ◽  
The Impact

OBJECT To the authors' knowledge, no previous study has examined the impact of meningioma diagnosis on women's birth desires and intentions. In an exploratory study, the authors surveyed women affected by meningioma to determine their attitudes toward childbearing and the influences, including physician recommendations, on this major life decision and compared their responses to those of women in the general population. METHODS Meningioma survivors from the Meningioma Mommas online support group participated in an online survey that included questions on their birth desires and intentions, whether the risk of disease recurrence influenced their reproductive decisions, and risks communicated to them by their physicians. Using chi-square and rank-sum tests, the authors compared the survey participants' responses with those of the general population as assessed by the 2006–2010 National Survey of Family Growth. Logistic regression was used to adjust for differences in age, race, ethnicity, education, parity, pregnancy status, and infertility status in these populations. RESULTS Respondents with meningioma were more likely than those in the general population to report wanting a baby (70% vs 54%, respectively), intending to have a baby (27% vs 12%, respectively), and being very sure about this intention (10% vs 2%, respectively). More than half (32 of 61) of the women of childbearing age reported being advised by a physician about potential risk factors for recurrence of the meningioma, and pregnancy was the most commonly cited risk factor (26 of 61). The most common factor influencing birth desires and intentions was risk of the meningioma returning and requiring more treatment, which was reported by nearly two-thirds of the women in their childbearing years. CONCLUSIONS A majority of the meningioma survivors of childbearing age who completed the survey reported a desire for children, although concern about the risk of meningioma recurrence was an important factor for these women when making reproductive decisions. Physicians are in a position to educate their patients on potential risk factors for recurrence and to provide contact information for services such as counseling and family planning.

Sex Differences in Interpreting Male-Female Dyad Interactions: Males' Predominance in Perceiving Sexual Intent

2002 ◽  
Vol 9 (3) ◽  
pp. 289-297 ◽  
Author(s):  
Aldert Vrij ◽  
Emma Kirby
Keyword(s):  
Gender Differences ◽  
Sex Differences ◽  
Social Environment ◽  
Rape Myths ◽  
Rape Myth ◽  
Sexual Intent ◽  
Female Dyad ◽  
Acceptance Scale ◽  
Males And Females ◽  
The Impact

Astudy is reported investigating gender differences in judging the behaviour of males and females during mixed-dyad conversations and the impact of the endorsement of rape myths in explaining these gender differences. A total of 51 males and 40 females watched a videotape of a male actor and female actor verbally interacting in a social environment and were asked to give their impression about this interaction. They were also requested to fill in the Rape Myths Acceptance Scale (1980). Results revealed that compared to females, males had a stronger tendency to see the interaction in sexual terms. Also, male participants endorsed rape myths more strongly. Finally, gender differences in rape myth endorsements accounted for gender differences in perceiving male-female mixed-dyad interactions to alimited extent. Implications of the findings are discussed.

Assessment of The Influence of Non-Genetic Risk Factors on The Disease Onset and Progression of Androgenetic Alopecia in Egyptian Males

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Naziha Hafez Khafagy ◽  
Marwa Yassin Soltan ◽  
Ahmed Adel Ali Ali
Keyword(s):  
Risk Factors ◽  
Hair Loss ◽  
Genetic Risk ◽  
Disease Onset ◽  
Genetic Risk Factors ◽  
Androgenetic Alopecia ◽  
Major Type ◽  
Young Males ◽  
Potential Risk Factors ◽  
The Impact

Abstract Background Androgenetic alopecia (AGA) is a patterned hair loss with multifactorial background including genetic, hormonal as well as environmental and lifestyle-related risk factors. The impact of non-genetic risk factors on the onset and disease progression of androgenetic alopecia in Egyptian males. Objective To explore the potential role of non-genetic risk factors on the disease development and progression of androgenetic alopecia in Egyptian males. Patients and Methods The study included 2000 subjects with and without AGA, during the period from February 2019 to September 2019. The study protocol was approved by faculty of medicine, Ain Sham University, Research ethics committee (FWA 000017585). An informed written consent for participation in this study was obtained from patients and controls before enrollment. One thousand male patients with AGA were recruited in the study. The diagnosis was made via clinical diagnosis, dermatological findings, trichoscopic assessment. Results Our study showed that after skin examination 416 patients had acne and 344 patients had seborrhea, with statistically significant association to AGA cases. Conclusion From our study, it can be concluded that AGA became a major type of hair loss complaint among Egyptian males especially young males. Many potential risk factors were found to be associated with the disease as smoking, stress, obesity, family history, exercise, HTN and unbalanced diet. Avoidance of such risk factors may help improve the disease.

PRIMARY PREVENTION OF DEMENTIA: AN EPIDEMIOLOGICAL POINT OF VIEW

2016 ◽  
pp. 1-4
Author(s):  
C. Berr
Keyword(s):  
Risk Factors ◽  
Primary Prevention ◽  
Disease Onset ◽  
Point Of View ◽  
Level Of Evidence ◽  
Life Course Approach ◽  
Important Concern ◽  
Dementia Prevention ◽  
Underlying Mechanisms ◽  
The Impact

From an epidemiological perspective, in order to increase the level of evidence, it is necessary to refer to data from longitudinal studies to validate the temporal relationship between exposure (e.g. the behavior or modifying factor) and the disease. Findings from such studies are useful for defining risk factors and laying the groundwork for proposing interventions for prevention. This step is crucial in order to define the periods (life-course approach) and groups at risk, which will then become the targets of interventions designed to modify behaviors or lifestyle. Specifying the underlying mechanisms of these risk factors is one of the objectives of etiological epidemiology which focuses on the origin of diseases but is not essential for a more pragmatic interventional approach. These questions are essential for dementia prevention and are discussed in this paper. Furthermore, timing interventions is a major problem even if we identify primary prevention pathways in dementia. Another important concern for epidemiologists is the need to make projections to estimate the number of dementia cases in the next decades considering different intervention scenarios. These models require adequate descriptive indicators of dementia, demography and mortality and precise estimations of the impact of potential interventions in terms of delaying disease onset for instance.

scholarly journals Prevalence and Risk Factors of Myopia in Spain

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Cristina C. Alvarez-Peregrina ◽  
Miguel Angel M. A. Sanchez-Tena ◽  
Clara C. Martinez-Perez ◽  
Cesar C. Villa-Collar
Keyword(s):  
Risk Factors ◽  
Visual Acuity ◽  
Family History ◽  
High Myopia ◽  
Electronic Devices ◽  
Geographical Data ◽  
Binocular Function ◽  
Number Of Children ◽  
Eye Examination ◽  
The Impact

Objective. To analyse the prevalence of myopia among a sample of more than 6000 children in Spain as well as to determine the impact of risk factors in its progression. Methodology. A total of 6,152 children aged from 5 to 7 were examined. The participants underwent an eye examination that included visual acuity, refraction without cycloplegia, and tests of accommodative and binocular function. In addition, a questionnaire regarding their lifestyle, family history, and geographical data was carried out. Finally, data were analysed using the SPSS version 25 program. Results. The prevalence of myopia in the sample of children studied has increased from 17% in 2016 to 20% in 2017. Likewise, the number of children with high myopia has also increased, from 1.7% in 2016 to 3.6% in 2017. 43.3% of the participants spent more than 3 hours a day doing near activities, and 48.9% of this group spent more than 50% of this time using electronic devices. In addition, only 9.7% spent more than 2.5 hours outdoors each day. Conclusion. Myopia prevalence appears to be increasing in Spain. Lifestyle factors appear to be increasing the risk of myopia.

scholarly journals A logistic regression analysis of risk factors in ME/CFS pathogenesis

BMC Neurology ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Eliana M. Lacerda ◽  
Keith Geraghty ◽  
Caroline C. Kingdon ◽  
Luigi Palla ◽  
Luis Nacul
Keyword(s):  
Risk Factors ◽  
Multiple Sclerosis ◽  
Regression Analysis ◽  
Risk Factor ◽  
Family History ◽  
Disease Onset ◽  
Healthy Controls ◽  
Lower Income ◽  
Wide Range ◽  
History Of

Abstract Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex disease, whose exact cause remains unclear. A wide range of risk factors has been proposed that helps understanding potential disease pathogenesis. However, there is little consistency for many risk factor associations, thus we undertook an exploratory study of risk factors using data from the UK ME/CFS Biobank participants. We report on risk factor associations in ME/CFS compared with multiple sclerosis participants and healthy controls. Methods This was a cross-sectional study of 269 people with ME/CFS, including 214 with mild/moderate and 55 with severe symptoms, 74 people with multiple sclerosis (MS), and 134 healthy controls, who were recruited from primary and secondary health services. Data were collected from participants using a standardised written questionnaire. Data analyses consisted of univariate and multivariable regression analysis (by levels of proximity to disease onset). Results A history of frequent colds (OR = 8.26, P <= 0.001) and infections (OR = 25.5, P = 0.015) before onset were the strongest factors associated with a higher risk of ME/CFS compared to healthy controls. Being single (OR = 4.41, P <= 0.001), having lower income (OR = 3.71, P <= 0.001), and a family history of anxiety is associated with a higher risk of ME/CFS compared to healthy controls only (OR = 3.77, P < 0.001). History of frequent colds (OR = 6.31, P < 0.001) and infections before disease onset (OR = 5.12, P = 0.005), being single (OR = 3.66, P = 0.003) and having lower income (OR = 3.48, P = 0.001), are associated with a higher risk of ME/CFS than MS. Severe ME/CFS cases were associated with lower age of ME/CFS onset (OR = 0.63, P = 0.022) and a family history of neurological illness (OR = 6.1, P = 0.001). Conclusions Notable differences in risk profiles were found between ME/CFS and healthy controls, ME/CFS and MS, and mild-moderate and severe ME/CFS. However, we found some commensurate overlap in risk associations between all cohorts. The most notable difference between ME/CFS and MS in our study is a history of recent infection prior to disease onset. Even recognising that our results are limited by the choice of factors we selected to investigate, our findings are consistent with the increasing body of evidence that has been published about the potential role of infections in the pathogenesis of ME/CFS, including common colds/flu.

Genetic and environmental influences on last-year major depression in adulthood: a highly heritable stable liability but strong environmental effects on 1-year prevalence

2017 ◽  
Vol 47 (10) ◽  
pp. 1816-1824 ◽  
Author(s):  
K. S. Kendler ◽  
C. O. Gardner
Keyword(s):  
Risk Factors ◽  
Major Depression ◽  
Environmental Effects ◽  
Environmental Risk ◽  
Structural Equation ◽  
Environmental Influences ◽  
Diagnostic Error ◽  
Environmental Risk Factors ◽  
Multiple Time ◽  
The Impact

BackgroundThis study seeks to clarify the contribution of temporally stable and occasion-specific genetic and environmental influences on risk for major depression (MD).MethodOur sample was 2153 members of female–female twin pairs from the Virginia Twin Registry. We examined four personal interview waves conducted over an 8-year period with MD in the last year defined by DSM-IV criteria. We fitted a structural equation model to the data using classic Mx. The model included genetic and environmental risk factors for a latent, stable vulnerability to MD and for episodes in each of the four waves.ResultsThe best-fit model was simple and included genetic and unique environmental influences on the latent liability to MD and unique wave-specific environmental effects. The path from latent liability to MD in the last year was constant over time, moderate in magnitude (+0.65) and weaker than the impact of occasion-specific environmental effects (+0.76). Heritability of the latent stable liability to MD was much higher (78%) than that estimated for last-year MD (32%). Of the total unique environmental influences on MD, 13% reflected enduring consequences of earlier environmental insults, 17% diagnostic error and 70% wave-specific short-lived environmental stressors.ConclusionsBoth genetic influences on MD and MD heritability are stable over middle adulthood. However, the largest influence on last-year MD is short-lived environmental effects. As predicted by genetic theory, the heritability of MD is increased substantially by measurement at multiple time points largely through the reduction of the effects of measurement error and short-term environmental risk factors.

scholarly journals Gender-related differences in MEN1 lesion occurrence and diagnosis: a cohort study of 734 cases from the Groupe d'étude des Tumeurs Endocrines

2011 ◽  
Vol 165 (1) ◽  
pp. 97-105 ◽  
Author(s):  
P Goudet ◽  
C Bonithon-Kopp ◽  
A Murat ◽  
P Ruszniewski ◽  
P Niccoli ◽  
...  
Keyword(s):  
Family History ◽  
Pituitary Tumor ◽  
Disease Gene ◽  
Pituitary Tumors ◽  
Pancreatic Tumors ◽  
History Of ◽  
Tumeurs Endocrines ◽  
Males And Females ◽  
The Impact

ContextMultiple endocrine neoplasia type 1 (MEN1) disease is an autosomal dominant syndrome that is believed to equally affect men and women. This assumption has never been confirmed.ObjectiveThe aims of this study were to evaluate the impact of gender on the prevalence of MEN1 lesions, on their lifetime probability of occurrence, and on the diagnosis of MEN1.DesignData regarding a study of 734 cases of MEN1 from the multicenter ‘Groupe d'étude des Tumeurs Endocrines’ were analyzed.ResultsThere were 57.8% females. The prevalence and probability of pancreatic tumors were higher in males than in females (P=0.06, P=0.0004). This difference was due to gastrinomas. The prevalence and probability of developing pituitary tumors were significantly greater in females (P<0.001, P<0.0001). Thymic tumors were exclusively found in men. There were no significant gender differences in the prevalence and the probability of developing hyperparathyroidism, or adrenal and bronchial tumors, or in the proportion of positive genetic tests. A family history of MEN1 was more frequently found in men than in women at the time of diagnosis (P=0.02). In the case of pituitary tumor, the proportion of patients diagnosed with MEN1 at the time of the first lesion was lower in women (44.2%) than in men (67.3%).ConclusionThe phenotype expression of the MEN1 disease gene was different in males and females. In female patients, the possibility of MEN1 is not sufficiently taken into account. Any patient presenting a lesion that belongs to the MEN1 spectrum, such as a pituitary tumor, should be closely questioned about their family history and should be tested for hypercalcemia.

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