[P1-093]: REGULATION OF ALZHEIMER's DISEASE-ASSOCIATED MRNA EXPRESSION BY GREEN TEA CATECHINS AND BLACK TEA THEAFLAVINS

2017 ◽  
Vol 13 (7S_Part_5) ◽  
pp. P274-P275 ◽  
Author(s):  
Ryan J. Geiser ◽  
Shelby E. Chastain ◽  
Melissa A. Moss
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mrna Expression ◽  
Green Tea ◽  
Black Tea ◽  
Tea Catechins ◽  
Green Tea Catechins

Anti-inflammatory activity and molecular mechanism of Oolong tea theasinensin

2014 ◽  
Vol 5 (8) ◽  
pp. 1891-1897 ◽  
Author(s):  
Ayami Hisanaga ◽  
Hisako Ishida ◽  
Kozue Sakao ◽  
Takayuki Sogo ◽  
Takuma Kumamoto ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Green Tea ◽  
Bioactive Compounds ◽  
Black Tea ◽  
Tea Polyphenols ◽  
Inflammatory Activity ◽  
Tea Catechins ◽  
Oolong Tea ◽  
Green Tea Catechins ◽  
Anti Inflammatory

Oolong tea theasinensins are a group of tea polyphenols different from green tea catechins and black tea theaflavins, and they are considered as bioactive compounds in oolong tea.

Inhibition of 17α-Hydroxylase/C17,20-Lyase (CYP17) from Rat Testis by Green Tea Catechins and Black Tea Theaflavins

2007 ◽  
Vol 71 (9) ◽  
pp. 2325-2328 ◽  
Author(s):  
Ken-ichi KIMURA ◽  
Yoshie ITAKURA ◽  
Reika GOTO ◽  
Masato TOJIMA ◽  
Nobumi EGAWA ◽  
...  
Keyword(s):  
Green Tea ◽  
Black Tea ◽  
Tea Catechins ◽  
Rat Testis ◽  
Green Tea Catechins

scholarly journals Inhibition of Collagenases from Mouse Lung Carcinoma Cells by Green Tea Catechins and Black Tea Theaflavins

1997 ◽  
Vol 61 (9) ◽  
pp. 1504-1506 ◽  
Author(s):  
Masaki Sazuka ◽  
Hirokazu Imazawa ◽  
Yutaka Shoji ◽  
Takashi Mita ◽  
Yukihiko Hara ◽  
...  
Keyword(s):  
Green Tea ◽  
Lung Carcinoma ◽  
Black Tea ◽  
Carcinoma Cells ◽  
Mouse Lung ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Lung Carcinoma Cells

Green tea catechins attenuate high-fat diet effects related to obesity and diabetes without effect hypothalamic expression of TLR4 pathway or serotoninergic 1B and 2C receptors

2013 ◽  
Author(s):  
Marcos Hiromu Okuda ◽  
de Santana Aline Alves ◽  
Mayara Franzoi Moreno ◽  
Ana Claudia Hachul ◽  
Nelson Inacio Neto ◽  
...  
Keyword(s):  
Green Tea ◽  
High Fat Diet ◽  
High Fat ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Obesity And Diabetes

MiR-335-5p Inhibits β-Amyloid (Aβ) Accumulation to Attenuate Cognitive Deficits Through Targeting c-jun-N-terminal Kinase 3 in Alzheimer’s Disease

2020 ◽  
Vol 17 (1) ◽  
pp. 93-101 ◽  
Author(s):  
Dan Wang ◽  
Zhifu Fei ◽  
Song Luo ◽  
Hai Wang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transgenic Mice ◽  
Western Blot ◽  
Mrna Expression ◽  
Cognitive Deficits ◽  
Protein Levels ◽  
Amyloid Aβ ◽  
Β Amyloid ◽  
The Relationship

Objectives: Alzheimer's disease (AD), also known as senile dementia, is a common neurodegenerative disease characterized by progressive cognitive impairment and personality changes. Numerous evidences have suggested that microRNAs (miRNAs) are involved in the pathogenesis and development of AD. However, the exact role of miR-335-5p in the progression of AD is still not clearly clarified. Methods: The protein and mRNA levels were measured by western blot and RNA extraction and quantitative real-time PCR (qRT-PCR), respectively. The relationship between miR-335-5p and c-jun-N-terminal kinase 3 (JNK3) was confirmed by dual-luciferase reporter assay. SH-SY5Y cells were transfected with APP mutant gene to establish the in vitro AD cell model. Flow cytometry and western blot were performed to evaluate cell apoptosis. The APP/PS1 transgenic mice were used as an in vivo AD model. Morris water maze test was performed to assess the effect of miR- 335-5p on the cognitive deficits in APP/PS1 transgenic mice. Results: The JNK3 mRNA expression and protein levels of JNK3 and β-Amyloid (Aβ) were significantly up-regulated, and the mRNA expression of miR-335-5p was down-regulated in the brain tissues of AD patients. The expression levels of miR-335-5p and JNK3 were significantly inversely correlated. Further, the dual Luciferase assay verified the relationship between miR-335- 5p and JNK3. Overexpression of miR-335-5p significantly decreased the protein levels of JNK3 and Aβ and inhibited apoptosis in SH-SY5Y/APPswe cells, whereas the inhibition of miR-335-5p obtained the opposite results. Moreover, the overexpression of miR-335-5p remarkably improved the cognitive abilities of APP/PS1 mice. Conclusion: The results revealed that the increased JNK3 expression, negatively regulated by miR-335-5p, may be a potential mechanism that contributes to Aβ accumulation and AD progression, indicating a novel approach for AD treatment.

The Protective Effects of Green Tea Catechins in the Management of Neurodegenerative Diseases: A Review

2019 ◽  
Vol 16 (1) ◽  
pp. 57-65 ◽  
Author(s):  
Tahereh Farkhondeh ◽  
Hanieh Shaterzadeh Yazdi ◽  
Saeed Samarghandian
Keyword(s):  
Neurodegenerative Diseases ◽  
Signaling Pathways ◽  
Green Tea ◽  
Molecular Mechanisms ◽  
Main Role ◽  
Related Factor ◽  
Protective Effects ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
And Control

Background: The therapeutic strategies to manage neurodegenerative diseases remain limited and it is necessary to discover new agents for their prevention and control. Oxidative stress and inflammation play a main role in the pathogenesis of neurodegenerative diseases. The aim of this study is to review the effects of green tea catechins against the Neurodegenerative Diseases. Methods: In this study, we extensively reviewed all articles on the terms of Green tea, catechins, CNS disorders, and different diseases in PubMed, Science Direct, Scopus, and Google Scholar databases between the years 1990 and 2017. Results: The present study found that catechins, the major flavonoids in green tea, are powerful antioxidants and radical scavengers which possess the potential roles in the management of neurodegenerative diseases. Catechins modulate the cellular and molecular mechanisms through the inflammation-related NF-&amp;#954;B and the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways. Conclusion: The findings of the present review shows catechins could be effective against neurodegenerative diseases due to their antioxidation and anti-inflammation effects and the involved biochemical pathways including Nrf2 and NF-kB signaling pathways.<P&gt;

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