P1-271: URINE ALBUMIN-TO-CREATININE RATIO TRAJECTORIES IN EARLY ADULTHOOD AND COGNITIVE FUNCTION IN MIDDLE AGE

BackgroundStudies with single baseline measurements of cognitive function consistently reveal inverse relationships with mortality risk. The relation of change in functioning, particularly from early in the life course, which may offer additional insights into causality, has not, to the best of our knowledge, been tested.AimsTo examine the association of change in cognition between late adolescence and middle age with cause-specific mortality using data from a prospective cohort study.MethodsThe analytical sample consisted of 4289 former US male military personnel who were administered the Army General Technical Test in early adulthood (mean age 20.4 years) and again in middle age (mean age 38.3 years).ResultsA 15-year period of mortality surveillance subsequent to the second phase of cognitive testing gave rise to 237 deaths. Following adjustment for age, a 10-unit increase in cognitive function was related to a reduced risk of death from all causes (HR 0.84; 95% CI 0.75 to 0.93) and cardiovascular disease (HR 0.78; 95% CI 0.64 to 0.95) but not from all cancers (HR 1.14; 95% CI 0.88 to 1.47) nor injury (HR 1.02; 95% CI 0.81 to 1.29). Adjustment for markers of socioeconomic status in middle age resulted in marked attenuation in the magnitude of these associations and statistical significance at conventional levels was lost in all analyses.ConclusionsIn the present study, the apparent link between increased cognition and mortality was mediated by socioeconomic status.

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Performance Evaluation of MEDITAPE UC-11A Strip Test in Estimating the Urine Albumin-to-Creatinine Ratio and Urine Protein-to-Creatinine Ratio

Laboratory Medicine Online ◽

10.3343/lmo.2020.10.1.52 ◽

2020 ◽

Vol 10 (1) ◽

pp. 52

Author(s):

Shinae Yu ◽

Sae Am Song ◽

Kyung Ran Jun ◽

Jeong Nyeo Lee

Keyword(s):

Performance Evaluation ◽

Creatinine Ratio ◽

Urine Protein ◽

Urine Albumin ◽

Strip Test

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Urine Albumin to Creatinine Ratio and Echocardiographic Left Ventricular Structure and Function in Patients with Essential Hypertension

The American Heart Hospital Journal ◽

10.15420/ahhj.2011.9.2.90 ◽

2011 ◽

Vol 9 (2) ◽

pp. 90 ◽

Cited By ~ 2

Author(s):

Rohola Hemmati ◽

Mojgan Gharipour ◽

Hasan Shemirani ◽

Alireza Khosravi ◽

Elham Khosravi ◽

...

Keyword(s):

Essential Hypertension ◽

Peak Velocity ◽

Left Ventricular ◽

Lv Function ◽

Creatinine Ratio ◽

Uncomplicated Hypertension ◽

Urine Albumin ◽

Lv Dysfunction ◽

Mitral Annulus Velocity ◽

Lv Mass

Background:Appearance of microalbuminuria, particularly in patients with hypertension, might be associated with a higher prevalence of left ventricular (LV) dysfunction and geometric abnormalities. This study was undertaken to determine whether high urine albumin to creatinine ratio (UACR) as a sensitive marker for microalbuminuria can be associated with LV hypertrophy (LVH) and systolic and diastolic LV dysfunction.Methods:The study population consisted of 125 consecutive patients with essential uncomplicated hypertension. Urine albumin and creatinine concentration was determined by standard methods. LVH was defined as a LV mass index >100 g/m2 of body surface area in women and >130 g/m2 in men. Echocardiographic LV systolic and diastolic parameters were measured.Results:The prevalence of microalbuminuria in patients with essential hypertension was 5.6 %. UACR was significantly no different in patients with LVH than in patients with normal LV geometry (21.26 ± 31.55 versus 17.80 ± 24.52 mg/mmol). No significant correlation was found between UACR measurement and systolic and diastolic function parameters, including early to late diastolic peak velocity (E/A) ratio (R=-0.192, p=0.038), early diastolic peak velocity to early mitral annulus velocity (E/E') ratio (R=-0.025, p=0.794), LV ejection fraction (R=0.008, p=0.929), and LV mass (R=-0.132, p=0.154). According to the receiver operator characteristic (ROC) curve analysis, UACR measurement was not an acceptable indicator of LVH with areas under the ROC curves 0.514 (95 % confidence interval 0.394–0.634). The optimal cut-off value for UACR for predicting LVH was identified at 9.4, yielding a sensitivity of 51.6 % and a specificity of 48.3 %.Conclusion:In patients with uncomplicated essential hypertension, abnormal systolic and diastolic LV function and geometry cannot be effectively predicted by the appearance of microalbuminuria.

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Life-Course Glucose Trajectory and Cognitive Function in Middle Age—Evidence from the Bogalusa Heart Study

Diabetes ◽

10.2337/db18-1474-p ◽

2018 ◽

Vol 67 (Supplement 1) ◽

pp. 1474-P

Author(s):

PATRICK STUCHLIK ◽

OWEN CARMICHAEL ◽

EMILY HARVILLE ◽

HUA HE ◽

MARYELLEN ROMERO ◽

...

Keyword(s):

Cognitive Function ◽

Life Course ◽

Middle Age ◽

Bogalusa Heart Study ◽

Heart Study

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Conversion of Urine Protein–Creatinine Ratio or Urine Dipstick Protein to Urine Albumin–Creatinine Ratio for Use in Chronic Kidney Disease Screening and Prognosis

Annals of Internal Medicine ◽

10.7326/m20-0529 ◽

2020 ◽

Vol 173 (6) ◽

pp. 426-435 ◽

Cited By ~ 2

Author(s):

Keiichi Sumida ◽

Girish N. Nadkarni ◽

Morgan E. Grams ◽

Yingying Sang ◽

Shoshana H. Ballew ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Disease Screening ◽

Creatinine Ratio ◽

Urine Protein ◽

Albumin Creatinine Ratio ◽

Urine Dipstick ◽

Urine Albumin ◽

Urine Albumin Creatinine Ratio

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Leisure time physical activity throughout adulthood is associated with lower medicare costs: evidence from the linked NIH-AARP diet and health study cohort

BMJ Open Sport & Exercise Medicine ◽

10.1136/bmjsem-2021-001038 ◽

2021 ◽

Vol 7 (1) ◽

pp. e001038

Author(s):

Diarmuid Coughlan ◽

Pedro F Saint-Maurice ◽

Susan A Carlson ◽

Janet Fulton ◽

Charles E Matthews

Keyword(s):

Physical Activity ◽

Healthcare Costs ◽

Middle Age ◽

Leisure Time Physical Activity ◽

Early Adulthood ◽

Later Life ◽

Health Study ◽

Activity Levels ◽

Physical Activity Levels ◽

Medicare Costs

BackgroundThere is limited information about the association between long-term leisure time physical activity (LTPA) participation and healthcare costs. The purpose of this study was to investigate the association between LTPA over adulthood with later life healthcare costs in the USA.MethodsUsing Medicare claims data (between 1999 and 2008) linked to the National Institutes of Health-American Association of Retired Persons (NIH-AARP) Diet and Health Study, we examined associations between nine trajectories of physical activity participation throughout adulthood with Medicare costs.ResultsCompared with adults who were consistently inactive from adolescence into middle age, average annual healthcare costs were significantly lower for maintainers, adults who maintained moderate (–US$1350 (95% CI: –US$2009 to –US$690) or −15.9% (95% CI: −23.6% to −8.1%)) or high physical activity levels (–US$1200 (95% CI: –US$1777 to –US$622) or −14.1% (95% CI: −20.9% to −7.3%)) and increasers, adults who increased physical activity levels in early adulthood (–US$1874 (95% CI: US$2691 to –US$1057) or −22.0% (95% CI: −31.6% to −12.4%)) or in middle age (–US$824 (95% CI: –US$1580 to –US$69 or −9.7% (95% CI −18.6% to −0.8%)). For the four trajectories where physical activity decreased, the only significant difference was for adults who increased physical activity levels during early adulthood with a decline in middle age (–US$861 (95% CI:–US$1678 to –US$45) or −10.1% (95% CI: −19.7% to −0.5%)).ConclusionOur analyses suggest the healthcare cost burden in later life could be reduced through promotion efforts supporting physical activity participation throughout adulthood.

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