P4-408: SEASONAL VARIATION OF COGNITIVE FUNCTION IN THE GENERAL POPULATION: THE ROTTERDAM STUDY

Abstract Seasonal variation in cognitive function and underlying cerebral hemodynamics in humans has been suggested, but not consistently shown in previous studies. We assessed cognitive function in 10,276 participants from the population-based Rotterdam Study, aged 45 years and older without dementia, at baseline and at subsequent visits between 1999 and 2016. Seasonality of five cognitive test scores and of a summary measure of global cognition were determined, as well as of brain perfusion. Using linkage with medical records, we also examined whether a seasonal variation was present in clinical diagnoses of dementia. We found a seasonal variation of global cognition (0.05 standard deviations [95% confidence interval: 0.02–0.08]), the Stroop reading task, the Purdue Pegboard test, and of the delayed world learning test, with the best performance in summer months. In line with these findings, there were fewer dementia diagnoses of dementia in spring and summer than in winter and fall. We found no seasonal variation in brain perfusion. These findings support seasonality of cognition, albeit not explained by brain perfusion.

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The neutrophil-to-lymphocyte ratio is associated with mortality in the general population: The Rotterdam Study

European Journal of Epidemiology ◽

10.1007/s10654-018-0472-y ◽

2018 ◽

Vol 34 (5) ◽

pp. 463-470 ◽

Cited By ~ 18

Author(s):

Jesse Fest ◽

T. Rikje Ruiter ◽

Bas Groot Koerkamp ◽

Dimitris Rizopoulos ◽

M. Arfan Ikram ◽

...

Keyword(s):

General Population ◽

Neutrophil To Lymphocyte Ratio ◽

Rotterdam Study ◽

Lymphocyte Ratio

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Does Violence Have Cognitive Correlates?

The British Journal of Psychiatry ◽

10.1192/bjp.151.1.63 ◽

1987 ◽

Vol 151 (1) ◽

pp. 63-68 ◽

Cited By ~ 20

Author(s):

G. Robertson ◽

P. J. Taylor ◽

J. C. Gunn

Keyword(s):

Cognitive Function ◽

General Population ◽

Psychiatric Illness ◽

Small Extent ◽

General Intelligence ◽

Reasoning Ability ◽

Violent Behaviour ◽

Cognitive Correlates ◽

General Ability ◽

The Relationship

The relationship between cognitive function and violence in 76 remanded prisoners, without formal psychiatric illness, was investigated. The violent group tended to be of slightly lower general ability than the non-violent group, but not abnormally so in relation to the general population; no relationship was found between specific patterns of cognitive functioning and violence. The violent group reported significantly higher levels of neurotic symptoms than the non-violent group, and were more socially deviant. To a small extent general intelligence (reasoning ability), in interaction with many other factors, may be related to a propensity for violent behaviour, but no particular aspect of cortical functioning seems to be related to violence.

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Cognition and obstructive sleep apnoea in Parkinson’s disease, effect of positive airway pressure therapy (COPE-PAP trial): protocol of a randomized controlled trial

International Journal of Clinical Trials ◽

10.18203/2349-3259.ijct20210143 ◽

2021 ◽

Vol 8 (1) ◽

pp. 35

Author(s):

Annie C. Lajoie ◽

Annie-Louise Lafontaine ◽

Gabriel Leonard ◽

R. John Kimoff ◽

Andrea Benedetti ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Cognitive Function ◽

General Population ◽

Cognitive Dysfunction ◽

Airway Pressure ◽

Positive Airway Pressure ◽

Controlled Trial ◽

Trial Registration ◽

Randomized Controlled ◽

Obstructive Sleep

Background: Parkinson’s disease (PD) is the second most frequent neurodegenerative disease and is associated with cognitive dysfunction. Obstructive sleep apnea (OSA) has been linked with cognitive dysfunction in the general population and in PD. Treatment with positive airway pressure (PAP), can improve cognition in the general population and in patients with other neurodegenerative diseases. However, the effect of PAP therapy on cognitive function has not been well studied in PD.Methods: This randomized controlled trial will assess the effect of 6 months of PAP therapy versus placebo on global cognitive function in PD patients with OSA and reduced baseline cognition. Secondary outcomes will include quality of life and other non-motor symptoms of PD. Exploratory outcomes will be specific domains of neurocognitive function and symptoms of REM sleep behaviour disorder.Conclusions: PD-related cognitive dysfunction often evolves towards dementia and has substantial personal, social and healthcare costs. Few interventions have been shown to improve cognition in PD to date. If positive, results from our study could prove OSA to be a new therapeutic target relevant to cognition and would support more systematic screening for OSA in PD patients with cognitive decline.Trial Registration: Trial registration number is NCT02209363.

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A simple test of copying ability and sex define survival in patients with early Alzheimer's disease

Psychological Medicine ◽

10.1017/s0033291798007375 ◽

1999 ◽

Vol 29 (2) ◽

pp. 485-489 ◽

Cited By ~ 13

Author(s):

J. J. CLAUS ◽

G. J. M. WALSTRA ◽

P. M. BOSSUYT ◽

S. TEUNISSE ◽

W. A. VAN GOOL

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Function ◽

General Population ◽

Survival Rates ◽

Symptom Duration ◽

Simple Test ◽

Kaplan Meier ◽

Early Alzheimer’S Disease

Background. We studied whether heterogeneous profiles of cognitive function are relevant to survival in patients with early Alzheimer's disease.Methods. CAMCOG subscales of cognitive function were used as predictors of survival, together with gender in 157 consecutively referred patients with early Alzheimer's disease. Statistical analysis was performed with Cox proportional hazards analysis and Kaplan–Meier survival curves. Survival rates were compared with those in the general population.Results. Eighty patients (51%) died during the follow-up that extended to 5·7 years, with a median survival of 4·4 years after entry. Only the praxis subscore was statistically significant related to survival (P<0·0001). Its predictive power was based on only two items, including copying ability for a spiral and a three-dimensional house, independent of age, sex, education, overall CAMCOG score, dementia severity and symptom duration. Kaplan–Meier curves for the combined score of these items (0, 1, or 2) showed three groups with significantly different survival rates for both men and women. Comparison of gender specific survival rates with data from the general population showed that excess mortality was statistically significant (P<0·01) higher in men (51%) than in women (21%) after follow-up extending to 5 years.Conclusions. A simple test of copying ability defines subgroups of AD patients with large differences in survival rates. This suggests that parietal lobe impairment is an important predictor of mortality in AD. Also, the course of AD may be more benign in women than in men.

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Intake of Vegetables and Fruits Through Young Adulthood Is Associated with Better Cognitive Function in Midlife in the US General Population

Journal of Nutrition ◽

10.1093/jn/nxz076 ◽

2019 ◽

Vol 149 (8) ◽

pp. 1424-1433

Author(s):

Xuanxia Mao ◽

Cheng Chen ◽

Pengcheng Xun ◽

Martha L Daviglus ◽

Lyn M Steffen ◽

...

Keyword(s):

Cognitive Function ◽

General Population ◽

Cognitive Performance ◽

Young Adulthood ◽

Verbal Learning ◽

Stroop Test ◽

Fruit Juices ◽

Digit Symbol Substitution Test ◽

Vegetables And Fruits

ABSTRACT Background Vegetables and fruits (VF) may differentially affect cognitive functions, presumably due to their various nutrient contents, but evidence from epidemiologic studies is limited. Objectives The aim of this study was to examine the long-term association between VF intakes, including VF subgroups, in young adulthood and cognitive function in midlife. Methods A biracial cohort of 3231 men and women aged 18–30 y at baseline in 1985–1986 were followed up for 25 y in the Coronary Artery Risk Development in Young Adults Study. Diet was measured at baseline, and in examination years 7 and 20. Cognitive function was assessed at examination year 25 through the use of 3 tests: the Rey Auditory Verbal Learning Test (RAVLT), the Digit Symbol Substitution Test (DSST), and the Stroop test. The mean differences (MDs) with 95% CIs in cognitive scores across intake categories were estimated through the use of the multivariable-adjusted general linear regression model. Results Excluding potatoes, intake of whole vegetables was significantly associated with a better cognitive performance after adjustment for potential confounders in all 3 cognitive tests (quintile 5 compared with quintile 1—RAVLT, MD: 0.33; 95% CI: 0.01, 0.64; P-trend = 0.08; DSST, MD: 2.84; 95% CI: 0.93, 4.75; P-trend < 0.01; Stroop test, MD: −2.87; 95% CI: −4.24, −1.50; P-trend < 0.01]. Similarly, intake of fruits, except fruit juices, was significantly related to a better cognitive performance (quintile 5 compared with quintile 1—DSST, MD: 2.41; 95% CI: 0.70, 4.12; P-trend = 0.03). Conclusions This study supports the long-term benefits of VF consumption on cognitive performance, except those VF with relatively low fiber content such as potatoes and fruit juices, among the middle-aged US general population.

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Cognitive and Prepulse Inhibition Deficits in Psychometrically High Schizotypal Subjects in the General Population: Relevance to Schizophrenia Research

Journal of the International Neuropsychological Society ◽

10.1017/s135561771200029x ◽

2012 ◽

Vol 18 (4) ◽

pp. 643-656 ◽

Cited By ~ 37

Author(s):

Stella G. Giakoumaki

Keyword(s):

Cognitive Function ◽

General Population ◽

Prepulse Inhibition ◽

Future Research ◽

Attention And Memory ◽

Schizophrenia Spectrum Disorders ◽

Schizotypal Personality ◽

Psychosis Proneness ◽

Schizophrenia Spectrum ◽

The Relationship

AbstractSchizophrenia and schizotypal personality disorder share common clinical profiles, neurobiological and genetic substrates along with Prepulse Inhibition and cognitive deficits; among those, executive, attention, and memory dysfunctions are more consistent. Schizotypy is considered to be a non-specific “psychosis-proneness,” and understanding the relationship between schizotypal traits and cognitive function in the general population is a promising approach for endophenotypic research in schizophrenia spectrum disorders. In this review, findings for executive function, attention, memory, and Prepulse Inhibition impairments in psychometrically defined schizotypal subjects have been summarized and compared to schizophrenia patients and their unaffected first-degree relatives. Cognitive flexibility, sustained attention, working memory, and Prepulse Inhibition impairments were consistently reported in high schizotypal subjects in accordance to schizophrenia patients. Genetic studies assessing the effects of various candidate gene polymorphisms in schizotypal traits and cognitive function are promising, further supporting a polygenic mode of inheritance. The implications of the findings, methodological issues, and suggestions for future research are discussed. (JINS, 2012, 18, 1–14)

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Seasonality of births in affective disorder in an Irish population

European Psychiatry ◽

10.1016/s0924-9338(99)80702-0 ◽

1998 ◽

Vol 13 (7) ◽

pp. 353-358 ◽

Cited By ~ 9

Author(s):

M Clarke ◽

F Keogh ◽

PT Murphy ◽

M Morris ◽

C Larkin ◽

...

Keyword(s):

Seasonal Variation ◽

Statistical Analysis ◽

General Population ◽

Affective Disorder ◽

Fourth Quarter ◽

Season Of Birth ◽

Irish Population ◽

Chi Square ◽

Chi Square Test ◽

Seasonality Of Births

SummarySeasonal variation in the births of patients with schizophrenia is a consistently replicated epidemiological finding. Few studies have investigated this phenomenon among patients with a diagnosis of affective disorder. The majority of season of birth studies have employed the chi square test for statistical analysis, a method that has been subject to some criticism. Using a Kolgomorov-Smirnov type statistic, the quarterly birth distribution of 6,646 patients with an ICD 9/10 diagnosis of affective disorder were compared to the general population. Only the births of those individuals with unipolar forms of affective disorder (n = 4,393) differed significantly from the general population, with significant excesses and deficits in the second quarter and fourth quarter respectively. These results were not altered by application of the displacement test. © 1998 Elsevier, Paris

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