scholarly journals Seasonality of cognitive function in the general population: the Rotterdam Study

GeroScience ◽  
2021 ◽  
Author(s):  
Sanne S. Mooldijk ◽  
Silvan Licher ◽  
Meike W. Vernooij ◽  
M. Kamran Ikram ◽  
M. Arfan Ikram
Keyword(s):  
Seasonal Variation ◽  
Cognitive Function ◽  
Medical Records ◽  
Brain Perfusion ◽  
Population Based ◽  
Cognitive Test ◽  
Rotterdam Study ◽  
Clinical Diagnoses ◽  
Global Cognition ◽  
Learning Test

Abstract Seasonal variation in cognitive function and underlying cerebral hemodynamics in humans has been suggested, but not consistently shown in previous studies. We assessed cognitive function in 10,276 participants from the population-based Rotterdam Study, aged 45 years and older without dementia, at baseline and at subsequent visits between 1999 and 2016. Seasonality of five cognitive test scores and of a summary measure of global cognition were determined, as well as of brain perfusion. Using linkage with medical records, we also examined whether a seasonal variation was present in clinical diagnoses of dementia. We found a seasonal variation of global cognition (0.05 standard deviations [95% confidence interval: 0.02–0.08]), the Stroop reading task, the Purdue Pegboard test, and of the delayed world learning test, with the best performance in summer months. In line with these findings, there were fewer dementia diagnoses of dementia in spring and summer than in winter and fall. We found no seasonal variation in brain perfusion. These findings support seasonality of cognition, albeit not explained by brain perfusion.

scholarly journals P4-408: SEASONAL VARIATION OF COGNITIVE FUNCTION IN THE GENERAL POPULATION: THE ROTTERDAM STUDY

2019 ◽  
Vol 15 ◽  
pp. P1458-P1458
Author(s):  
Silvan Licher ◽  
Magda Cepeda ◽  
Josje D. Schoufour ◽  
Maria J. Knol ◽  
M. Kamran Ikram ◽  
...  
Keyword(s):  
Seasonal Variation ◽  
Cognitive Function ◽  
General Population ◽  
Rotterdam Study

scholarly journals Cognitive trajectories from infancy to early adulthood following birth before 26 weeks of gestation: a prospective, population-based cohort study

2017 ◽  
Vol 103 (4) ◽  
pp. 363-370 ◽  
Author(s):  
Louise Linsell ◽  
Samantha Johnson ◽  
Dieter Wolke ◽  
Helen O’Reilly ◽  
Joan K Morris ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cognitive Function ◽  
Test Scores ◽  
Infant Development ◽  
Maternal Education ◽  
Early Adulthood ◽  
Population Based ◽  
Mean Difference ◽  
Cognitive Test ◽  
Extremely Preterm

ObjectiveTo determine the trajectory of cognitive test scores from infancy to adulthood in individuals born extremely preterm compared with term-born individuals.DesignA prospective, population-based cohort study.Setting276 maternity units in the UK and Ireland.Patients315 surviving infants born less than 26 completed weeks of gestation recruited at birth in 1995 and 160 term-born classroom controls recruited at age 6.Main outcome measuresBayley Scales of Infant Development-Second Edition (age 2.5); Kaufman Assessment Battery for Children (ages 6/11); Wechsler Abbreviated Scale of Intelligence-Second Edition (age 19).ResultsThe mean cognitive scores of extremely preterm individuals over the period were on average 25.2 points below their term-born peers (95% CI −27.8 to −22.6) and remained significantly lower at every assessment. Cognitive trajectories in term-born boys and girls did not differ significantly, but the scores of extremely preterm boys were on average 8.8 points below those of extremely preterm girls (95% CI −13.6 to −4.0). Higher maternal education elevated scores in both groups by 3.2 points (95% CI 0.8 to 5.7). Within the extremely preterm group, moderate/severe neonatal brain injury (mean difference: −10.9, 95% CI −15.5 to −6.3) and gestational age less than 25 weeks (mean difference: −4.4, 95% CI −8.4 to −0.4) also had an adverse impact on cognitive function.ConclusionsThere is no evidence that impaired cognitive function in extremely preterm individuals materially recovers or deteriorates from infancy through to 19 years. Cognitive test scores in infancy and early childhood reflect early adult outcomes.

scholarly journals Dietary Antioxidants and Cognitive Function in a Population-based Sample of Older Persons: The Rotterdam Study

1996 ◽  
Vol 144 (3) ◽  
pp. 275-280 ◽  
Author(s):  
J. W. Jama ◽  
L J. Launer ◽  
J. C. M. Witteman ◽  
J. H. den Breeijen ◽  
M. M. B. Breteler ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Older Persons ◽  
Population Based ◽  
Rotterdam Study ◽  
Dietary Antioxidants

scholarly journals Total Cerebral Blood Flow in Relation to Cognitive Function: The Rotterdam Scan Study

2008 ◽  
Vol 28 (10) ◽  
pp. 1652-1655 ◽  
Author(s):  
Mariëlle MF Poels ◽  
Mohammad Arfan Ikram ◽  
Meike W Vernooij ◽  
Gabriel P Krestin ◽  
Albert Hofman ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Function ◽  
Brain Atrophy ◽  
Brain Volume ◽  
Population Based ◽  
Cerebral Hypoperfusion ◽  
Information Processing Speed ◽  
Future Studies ◽  
Global Cognition

Cerebral hypoperfusion has been associated with worse cognitive function. We investigated the association between cerebral blood flow and cognition and whether this association is independent of brain volume. In 892 participants, aged 60 to 91 years, of the population-based Rotterdam Scan study, we measured total cerebral blood flow (tCBF) and brain volume using magnetic resonance imaging. Lower tCBF was associated with worse information-processing speed, executive function, and global cognition. However, after correcting tCBF for brain volume, these associations disappeared. The association between tCBF and cognition may be mediated or confounded by brain atrophy. Future studies on tCBF should take into account brain atrophy.

scholarly journals Regular Latin Dancing and Health Education May Improve Cognition of Late Middle-Aged and Older Latinos

2017 ◽  
Vol 25 (3) ◽  
pp. 482-489 ◽  
Author(s):  
David X. Marquez ◽  
Robert Wilson ◽  
Susan Aguiñaga ◽  
Priscilla Vásquez ◽  
Louis Fogg ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Health Education ◽  
Episodic Memory ◽  
Pilot Trial ◽  
Cognitive Test ◽  
Education Group ◽  
Time Interaction ◽  
Z Scores ◽  
Global Cognition ◽  
The Impact

Disparities exist between Latinos and non-Latino Whites in cognitive function. Dance is culturally appropriate and challenges individuals physically and cognitively, yet the impact of regular dancing on cognitive function in older Latinos has not been examined. A two-group pilot trial was employed among inactive, older Latinos. Participants (N = 57) participated in the BAILAMOS© dance program or a health education program. Cognitive test scores were converted to z-scores and measures of global cognition and specific domains (executive function, episodic memory, working memory) were derived. Results revealed a group × time interaction for episodic memory (p < .05), such that the dance group showed greater improvement in episodic memory than the health education group. A main effect for time for global cognition (p < .05) was also demonstrated, with participants in both groups improving. Structured Latin dance programs can positively influence episodic memory, and participation in structured programs may improve overall cognition among older Latinos.

Seasonal Variation in Fibrinogen in the Rotterdam Study

1997 ◽  
Vol 78 (03) ◽  
pp. 1059-1062 ◽  
Author(s):  
J G van der Bom ◽  
M P M de Maat ◽  
M L Bots ◽  
A Hofman ◽  
C Kluft ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Seasonal Variation ◽  
Hdl Cholesterol ◽  
The Elderly ◽  
Population Based ◽  
Seasonal Difference ◽  
Risk Indicator ◽  
Rotterdam Study ◽  
Outdoor Temperature ◽  
Cross Sectional

SummaryAs evidence accumulates to implicate fibrinogen as a risk indicator for cardiovascular disease, it is of interest to study its seasonal variation. A population based cross-sectional study was performed among participants of the Rotterdam Study, a cohort of 7,983 men and women, aged 55 years and over. Fibrinogen levels were measured by the prothrombin time derived method in the first 2,325 participants of the study. Fibrinogen levels were considerably higher in winter. The seasonal difference was 0.34 g/1 (95% confidence interval 0.29,0.39) and was more pronounced in subjects aged 75 years and over than in subjects aged 55 to 75 years, 0.43 g/1 (0.34,0.52) and 0.29 g/1 (0.24,0.35), respectively. Additional adjustment for body mass index, systolic and diastolic blood pressure, and total and HDL cholesterol did not materially change the findings. After adjustment for seasons, outdoor temperature was not associated with fibrinogen. Adjustment for outdoor temperature did not change the seasonal variation of fibrinogen, seasonal difference 0.31 g/1 (0.24, 0.37). In conclusion, fibrinogen levels are highest in Winter. The seasonal variation of fibrinogen is more pronounced in the elderly. Outdoor temperature does not seem to play a role in the seasonal variation of fibrinogen. Seasonal variation of fibrinogen may partly explain the increased cardiovascular disease mortality in Winter.

Abstract P421: Alternate Health Eating Index & Cognitive Function Among Middle-aged and Older Hispanics/ Latinos: The Hispanic Community Health Study/ Study of Latinos

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Mayra L Estrella ◽  
melissa lamar ◽  
Ramon A Durazo-Arvizu ◽  
Josiemer Mattei ◽  
Yasmin Mossavar-Rahmani ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Diet Quality ◽  
Processing Speed ◽  
Verbal Memory ◽  
Verbal Fluency ◽  
Verbal Learning ◽  
Healthy Eating Index ◽  
Cognitive Test ◽  
Middle Aged ◽  
Global Cognition

Introduction: A healthy diet may promote healthy cognitive aging; however, little is known about associations between diet quality and cognition in Hispanics/Latinos. Hypothesis: Higher diet quality (2010 Alternative Healthy Eating Index; AHEI-2010) is associated with better global cognition and performance on specific cognitive tests (verbal learning, memory, verbal fluency, and processing speed) in Hispanics/Latinos. Methods: Data from HCHS/SOL Visit 1 (2008-2011; n=8461; ages 45-74 years) were analyzed. The global cognition score was computed as the sum of z-scores for the individual tests. Dietary intake was assessed via two 24-hour recalls. Total AHEI-2010 score was categorized into quintiles (Q); higher Q represents higher diet quality. Cross-sectional associations between AHEI-2010 and each cognitive test were examined using survey-weighted linear regression models adjusted for age, sex, education, and total daily energy intake (Model 1); and Model 1 plus Hispanic/Latino heritage, annual household income, language preference, type 2 diabetes, smoking, and depressive symptoms (Model 2). Results: In minimally-adjusted models (Table 1), global cognition, verbal learning, verbal memory, verbal fluency, and processing speed scores were significantly higher by 1.32, 2.38, 1.40, 2.33, and 1.34 units for Q5 (vs. Q1). In fully-adjusted models, global cognitive function scores were significantly higher by 0.28, 0.52, and 0.48 units for Q2 through Q4 (vs. Q1; p -trend= 0.042). Verbal learning scores were significantly higher by 0.60, 0.62, 0.92, and 0.88 units for Q2 through Q5 (vs. Q1; p -trend= 0.020). Verbal memory scores were significantly higher by 0.33, 0.40, 0.52, and 0.46 units for Q2 through Q5 (vs. Q1; p -trend= 0.007). AHEI-2010 was not associated with verbal fluency and processing speed in Model 2. Conclusions: Among middle-aged and older Hispanics/Latinos, higher diet quality was associated with better global cognition, verbal learning, and memory, but not with verbal fluency, or processing speed.

Abstract 95: Nutrition and Cognitive Decline Over 21-years: Results from the Atherosclerosis Risk in Communities Study (ARIC)

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Jennifer L Dearborn ◽  
Aozhou Wu ◽  
Lyn M Steffen ◽  
David S Knopman ◽  
Thomas H Mosley ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Cognitive Decline ◽  
Cognitive Performance ◽  
Test Scores ◽  
Population Based ◽  
Word Recall ◽  
Cognitive Test ◽  
Z Score ◽  
Balanced Diet ◽  
Diet Pattern

Background: A healthy diet may be protective against cognitive decline by mechanisms that involve improved vascular risk factors such as hypertension and dysglycemia, and reduced systemic inflammation. In this population-based study, we hypothesized that midlife diet pattern would be associated with cognitive decline over 21-years. Methods: This study included 13,603 participants in the ARIC population-based cohort recruited from four U.S. sites who were aged 45 to 64 at baseline (1987-89) when diet was measured. Participants recorded diet using a 66-item food frequency questionnaire. Two dietary patterns, called “Meat and Fried” and the “Balanced Diet”, were named after the most representative foods that emerged from constructs derived from a principal component analysis of 30 food groups. A higher diet pattern score represented greater adherence. Cognitive testing, including the digit symbol substitution, the word fluency and delayed word recall tests, were combined to a z-score at each visit (visits 2, 1990-92; 4, 1996-98 and 5, 2011-2013). Test scores for participants not attending subsequent visits were imputed using Multiple Imputation by Chained Equations to account for cohort attrition. Cognitive performance at visit 2 was compared by tertile (T) of each diet pattern. Using mixed effects models with a random slope and intercept , we determined the 21-year change in cognitive function by diet pattern tertile, adjusting for demographics and medical history. Results: At visit 2, adherence to the Meat and Fried pattern was associated with lower cognitive test scores (z-score T3: -0.172, SD 0.985; T1: 0.149, SD 0.981, p-trend <0.001). Adherence to the Balanced Diet was not associated with differences in cognitive performance (z-score T3: 0.013, SD 0.988; T1 -0.036, SD 1.001, p-trend 0.10). 21-year change in cognitive function did not differ by adherence to diet pattern with adjustments (difference of the change in z-score for Meat and Fried, T3 vs. T1: 0.02, [CI -0.05 to 0.08]; Balanced Diet T3 vs. T1: -0.03, [CI -0.09 to 0.02]). Conclusion: Although participants with a diet pattern high in meat and fried foods had lower cognition at time of first assessment, diet patterns at midlife did not carry independent associations with cognitive decline.

scholarly journals US Older Adults That Consume Avocado or Guacamole Have Better Cognition Than Non-consumers: National Health and Nutrition Examination Survey 2011–2014

2021 ◽  
Vol 8 ◽  
Author(s):  
Feon W. Cheng ◽  
Nikki A. Ford ◽  
Matthew K. Taylor
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
National Health ◽  
Cognitive Test ◽  
Nutrition Examination Survey ◽  
Health And Nutrition ◽  
Special Cases ◽  
Z Scores ◽  
Global Cognition ◽  
Mean Differences

Purpose: The goal of this study is to examine how avocado relates to cognitive function among older adults.Methods: A total of 2,886 National Health and Nutrition Examination Survey 2011–2014 participants aged 60 or older met the eligibility criteria and were included of our cross-sectional study. Participants were binarily classified as avocado consumers (i.e., reported consuming any avocado/guacamole in either 24-h dietary recalls) or non-consumers. Cognitive performance was evaluated with: Consortium to Establish a Registry for Alzheimer's disease (CERAD)—immediate and delayed recall (IWR/DWR), the Animal Fluency test, and the Digit Symbol Substitution Test. We calculated the education-dependent z-scores for each subject because education level can impact cognitive function. Global cognitive score, an average of the z-scores for each cognitive test, was calculated in participants who had completed all four tests. To account for relevant covariates, we tested for mean differences in cognition between consumers and non-consumers using independent sample t-tests and ANCOVA, special cases of ordinary least squares regression.Results: Avocado consumers had significantly better cognitive scores across all cognitive tests and the global cognition score (p &lt; 0.05) in the unadjusted model. Some mean differences attenuated after adjusting for potential confounders, but others remained significant. Compared to non-consumers, avocado consumers had significantly higher z-scores of 0.15, 0.15, and 0.11 for CERAD IWR and DWR, and global cognition score, respectively (all p &lt; 0.05 in adjusted models).Conclusion: Avocado consumption was associated with significantly better IWR, DWR, and the overall global cognition score, which remained significant when controlling for all relevant confounders.

Sign in / Sign up

Export Citation Format

Share Document