The prognosis of heart failure in the general population. The Rotterdam Study

ObjectivesPrevious studies showed a strong association between sarcoidosis and heart failure (HF) but did not consider risk stratification or risk factors to identify useful aetiological insights. We estimated overall and stratified HRs and identified risk factors for HF in sarcoidosis.MethodsSarcoidosis cases were identified from the Swedish National Patient Register (NPR; ≥2 International Classification of Diseases-coded visits, 2003–2013) and matched to general population comparators. They were followed for HF in the NPR. Treated were cases who were dispensed ≥1 immunosuppressant ±3 months from the first sarcoidosis visit (2006–2013). Using Cox models, we estimated HRs adjusted for demographics and comorbidity and identified independent risk factors of HF together with their attributable fractions (AFs).ResultsDuring follow-up, 204 of 8574 sarcoidosis cases and 721 of 84 192 comparators were diagnosed with HF (rate 2.2 vs 0.7/1000 person-years, respectively). The HR associated with sarcoidosis was 2.43 (95% CI 2.06 to 2.86) and did not vary by age, sex or treatment status. It was higher during the first 2 years after diagnosis (HR 3.7 vs 1.9) and in individuals without a history of ischaemic heart disease (IHD; HR 2.7 vs 1.7). Diabetes, atrial fibrillation and other arrhythmias were the strongest independent clinical predictors of HF (HR 2.5 each, 2-year AF 20%, 16% and 12%, respectively).ConclusionsAlthough low, the HF rate was more than twofold increased in sarcoidosis compared with the general population, particularly right after diagnosis. IHD history cannot solely explain these risks, whereas ventricular arrhythmias indicating cardiac sarcoidosis appear to be a strong predictor of HF in sarcoidosis.

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Readability Assessment of Online Patient Education Material on Congestive Heart Failure

Advances in Preventive Medicine ◽

10.1155/2017/9780317 ◽

2017 ◽

Vol 2017 ◽

pp. 1-8 ◽

Cited By ~ 24

Author(s):

Akhil Kher ◽

Sandra Johnson ◽

Robert Griffith

Keyword(s):

Heart Failure ◽

Congestive Heart Failure ◽

Patient Education ◽

General Population ◽

Sixth Grade ◽

Assessment Tools ◽

Flesch Reading Ease ◽

Readability Assessment ◽

Readability Level ◽

Online Patient Education

Background. Online health information is being used more ubiquitously by the general population. However, this information typically favors only a small percentage of readers, which can result in suboptimal medical outcomes for patients. Objective. The readability of online patient education materials regarding the topic of congestive heart failure was assessed through six readability assessment tools. Methods. The search phrase “congestive heart failure” was employed into the search engine Google. Out of the first 100 websites, only 70 were included attending to compliance with selection and exclusion criteria. These were then assessed through six readability assessment tools. Results. Only 5 out of 70 websites were within the limits of the recommended sixth-grade readability level. The mean readability scores were as follows: the Flesch-Kincaid Grade Level (9.79), Gunning-Fog Score (11.95), Coleman-Liau Index (15.17), Simple Measure of Gobbledygook (SMOG) index (11.39), and the Flesch Reading Ease (48.87). Conclusion. Most of the analyzed websites were found to be above the sixth-grade readability level recommendations. Efforts need to be made to better tailor online patient education materials to the general population.

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Measures of body composition and risk of heart failure in the elderly: The Rotterdam study

The journal of nutrition health & aging ◽

10.1007/s12603-010-0288-2 ◽

2010 ◽

Vol 15 (5) ◽

pp. 393-397 ◽

Cited By ~ 4

Author(s):

M. A. W. Van Lieshout ◽

G. C. Verwoert ◽

F. U. S. Mattace-Raso ◽

M. C. Zillikens ◽

E. J. Sijbrands ◽

...

Keyword(s):

Heart Failure ◽

Body Composition ◽

The Elderly ◽

Rotterdam Study

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Diastolic dysfunction in individuals with and without heart failure with preserved ejection fraction

Clinical Research in Cardiology ◽

10.1007/s00392-021-01907-x ◽

2021 ◽

Author(s):

Jan-Per Wenzel ◽

Ramona Bei der Kellen ◽

Christina Magnussen ◽

Stefan Blankenberg ◽

Benedikt Schrage ◽

...

Keyword(s):

Risk Factors ◽

Heart Failure ◽

Cardiovascular Risk ◽

General Population ◽

Diastolic Dysfunction ◽

Cardiovascular Risk Factors ◽

Population Based ◽

Left Ventricular ◽

Health Study ◽

Common Finding

Abstract Aim Left ventricular diastolic dysfunction (DD), a common finding in the general population, is considered to be associated with heart failure with preserved ejection faction (HFpEF). Here we evaluate the prevalence and correlates of DD in subjects with and without HFpEF in a middle-aged sample of the general population. Methods and results From the first 10,000 participants of the population-based Hamburg City Health Study (HCHS), 5913 subjects (mean age 64.4 ± 8.3 years, 51.3% females), qualified for the current analysis. Diastolic dysfunction (DD) was identified in 753 (12.7%) participants. Of those, 11.2% showed DD without HFpEF (ALVDD) while 1.3% suffered from DD with HFpEF (DDwHFpEF). In multivariable regression analysis adjusted for major cardiovascular risk factors, ALVDD was associated with arterial hypertension (OR 2.0, p < 0.001) and HbA1c (OR 1.2, p = 0.007). Associations of both ALVDD and DDwHFpEF were: age (OR 1.7, p < 0.001; OR 2.7, p < 0.001), BMI (OR 1.2, p < 0.001; OR 1.6, p = 0.001), and left ventricular mass index (LVMI). In contrast, female sex (OR 2.5, p = 0.006), atrial fibrillation (OR 2.6, p = 0.024), CAD (OR 7.2, p < 0.001) COPD (OR 3.9, p < 0.001), and QRS duration (OR 1.4, p = 0.005) were strongly associated with DDwHFpEF but not with ALVDD. Conclusion The prevalence of DD in a sample from the first 10,000 participants of the population-based HCHS was 12.7% of whom 1.3% suffered from HFpEF. DD with and without HFpEF showed significant associations with different major cardiovascular risk factors and comorbidities warranting further research for their possible role in the formation of both ALVDD and DDwHFpEF.

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Managing heart failure – home or hospital?

Drug and Therapeutics Bulletin ◽

10.1136/dtb.30.16.61 ◽

1992 ◽

Vol 30 (16) ◽

pp. 61-63

Keyword(s):

Heart Failure ◽

General Practice ◽

General Population ◽

Mortality Rates ◽

The Usa ◽

The Uk

In the USA, heart failure affects about 1% of people in their 50s, rising to 10% of those in their 80s,1 and the figure is probably higher in the UK. The symptoms are distressing, usually relentless, and associated with mortality rates four to eight times greater than those in the general population of the same age.1 This article reviews the treatment of uncomplicated heart failure, concentrating on its management in general practice.

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The neutrophil-to-lymphocyte ratio is associated with mortality in the general population: The Rotterdam Study

European Journal of Epidemiology ◽

10.1007/s10654-018-0472-y ◽

2018 ◽

Vol 34 (5) ◽

pp. 463-470 ◽

Cited By ~ 18

Author(s):

Jesse Fest ◽

T. Rikje Ruiter ◽

Bas Groot Koerkamp ◽

Dimitris Rizopoulos ◽

M. Arfan Ikram ◽

...

Keyword(s):

General Population ◽

Neutrophil To Lymphocyte Ratio ◽

Rotterdam Study ◽

Lymphocyte Ratio

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Humanistic burden and economic impact of heart failure – a systematic review of the literature

F1000Research ◽

10.12688/f1000research.19365.1 ◽

2019 ◽

Vol 8 ◽

pp. 859 ◽

Cited By ~ 1

Author(s):

Lucia Giles ◽

Caroline Freeman ◽

Polly Field ◽

Elisabeth Sörstadius ◽

Bernt Kartman

Keyword(s):

Heart Failure ◽

Systematic Review ◽

General Population ◽

Economic Impact ◽

Chronic Diseases ◽

Resource Use ◽

Kansas City ◽

Short Form ◽

Cochrane Library ◽

Humanistic Burden

Background: Heart failure (HF) is increasing in prevalence worldwide. This systematic review was conducted to inform understanding of its humanistic and economic burden. Methods: Electronic databases (Embase, MEDLINE®, and Cochrane Library) were searched in May 2017. Data were extracted from studies reporting health-related quality of life (HRQoL) in 200 patients or more (published 2007–2017), or costs and resource use in 100 patients or more (published 2012–2017). Relevant HRQoL studies were those that used the 12- or 36-item Short-Form Health Surveys, EuroQol Group 5-dimensions measure of health status, Minnesota Living with Heart Failure Questionnaire or Kansas City Cardiomyopathy Questionnaire. Results: In total, 124 studies were identified: 54 for HRQoL and 71 for costs and resource use (Europe: 25/15; North America: 24/50; rest of world/multinational: 5/6). Overall, individuals with HF reported worse HRQoL than the general population and patients with other chronic diseases. Some evidence identified supports a correlation between increasing disease severity and worse HRQoL. Patients with HF incurred higher costs and resource use than the general population and patients with other chronic conditions. Inpatient care and hospitalizations were identified as major cost drivers in HF. Conclusions: Our findings indicate that patients with HF experience worse HRQoL and incur higher costs than individuals without HF or patients with other chronic diseases. Early treatment of HF and careful disease management to slow progression and to limit the requirement for hospital admission are likely to reduce both the humanistic burden and economic impact of HF.

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