Changes in Neutrophil Lymphocyte Ratio and Periaortic Fat Triggered by Rapid Weight Loss after Bariatric Surgery

Abstract Objectives Obesity and related diseases have become one of the most important health problems in the modern age. In addition to its clinical use in the treatment of obesity, bariatric surgery reduces obesity-induced inflammation. Neutrophil–lymphocyte ratio (NLR) is a cheap and easily attainable inflammatory marker. The purpose of this study is to show the effect of bariatric surgery on NLR at preoperative and postoperative 3rd, 6th, and 12th months after SG. Methods 298 patients, who underwent sleeve gastrectomy (SG) in general surgery clinic between 2015 and 2017, were included in the study. We excluded the patients younger than 18 years old, and did not have any inflammatory, infectious, hematological, and comorbide diseases such as diabetes mellitus, cardiovascular diseases, ischemic heart disease, hypertension, renal insufficiency, cancer, and respiratory problems like asthma, obstructive sleep apnea syndrome. We evaluated the levels of NLR at preoperative and postoperative 3rd, 6th, and 12th months visits. Results There were a total of 298 adult patients (age: mean 38.6, minimum 18, maximum 69 years old). Of whom 247 were female (82.9%) and 51 were male (17.1%). We found that NLR levels decreased significantly at 3rd, 6th, and 12th month visits after SG (p<0.001). Conclusions We concluded that NLR levels decrease after surgery in a proportional reduction in adipose tissue. The decrease in NLR levels may also be associated with the protective effects of sleeve gastrectomy against low-grade inflammation-related diseases.

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Very low-calorie diet in candidates for bariatric surgery: change in body composition during rapid weight loss

Clinics ◽

10.6061/clinics/2019/e560 ◽

2019 ◽

Vol 74 ◽

Cited By ~ 3

Author(s):

Marcela Pires Serafim ◽

Marco Aurelio Santo ◽

Alexandre Vieira Gadducci ◽

Veruska Magalhães Scabim ◽

Ivan Cecconello ◽

...

Keyword(s):

Bariatric Surgery ◽

Weight Loss ◽

Body Composition ◽

Rapid Weight Loss ◽

Very Low Calorie Diet ◽

Low Calorie ◽

Low Calorie Diet ◽

Calorie Diet

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The Impact of Rapid Weight Loss after Bariatric Surgery on Insulin Resistance Measured by the Triglyceride/HDL-Cholesterol Ratio and the Triglyceride-Glucose Index

Journal of the American College of Surgeons ◽

10.1016/j.jamcollsurg.2020.07.064 ◽

2020 ◽

Vol 231 (4) ◽

pp. S32

Author(s):

Cristina Botero Fonnegra ◽

Roberto J. Valera ◽

Mauricio Sarmiento-Cobos ◽

Jie Qin ◽

Emanuele Lo Menzo ◽

...

Keyword(s):

Insulin Resistance ◽

Bariatric Surgery ◽

Weight Loss ◽

Hdl Cholesterol ◽

Rapid Weight Loss ◽

Cholesterol Ratio ◽

Triglyceride Glucose Index ◽

The Impact

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The Impact of the Pre-operative Neutrophil-lymphocyte Ratio as the Predictive Marker of Post-operative Weight Loss and Improving Diabetes in Sleeve Gastrectomy.

10.21203/rs.3.rs-131065/v1 ◽

2020 ◽

Author(s):

Hideya Kashihara ◽

Mitsuo Shimada ◽

Kozo Yoshikawa ◽

Jun Higashijima ◽

Takuya Tokunaga ◽

...

Keyword(s):

Weight Loss ◽

Sleeve Gastrectomy ◽

Hemoglobin A1c ◽

Excess Weight Loss ◽

Predictive Marker ◽

Obese Patients ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Remission Of Diabetes ◽

The Impact

Abstract Background: The aim of this study was to investigate the impact of the neutrophil-lymphocyte ratio (NLR) in sleeve gastrectomy (SG).Methods: 15 obese patients were enrolled in this study. They consisted of 5 males and 10 females: mean body weight (BW) 127.5kg; mean body mass index (BMI) 46.7kg/m2. 10 of these were diabetics who underwent a SG. The impact of the pre-operative NLR on the percentage of excess weight loss (%EWL) and remission of diabetes 1 year post-operative were examined.Results: The BMI, %EWL and %TWL at 1 year post-operative were 35.1 kg/m2, 46.3% and 26.2%, respectively. Improvements were also evident in the diabetes at 1 year post-operative: complete remission (CR) (No medication and hemoglobin A1c (HbA1c) HbA1c<6.0%) 40%, PR (HbA1c<6.5) 20%; and (decrease of anti diabetic drug and HbA1c<7.0%) 40%. Comparing pre-operative NLR in %EWL<50% and >50% in one (1) year post-operative, <50% was 2.64 and >50% was 2.03 (p<0.05). The NLR in CR and partial remission (PR) was significantly lower than that in improved (Improve) (2.22 vs 3.27, p<0.05).Conclusions: The pre-operative NLR may be a predictive marker of weight loss and improving diabetes after SG.

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Bariatric Surgery and Brain Health—A Longitudinal Observational Study Investigating the Effect of Surgery on Cognitive Function and Gray Matter Volume

Nutrients ◽

10.3390/nu12010127 ◽

2020 ◽

Vol 12 (1) ◽

pp. 127 ◽

Cited By ~ 2

Author(s):

Kristin Prehn ◽

Thorge Profitlich ◽

Ida Rangus ◽

Sebastian Heßler ◽

A. Veronica Witte ◽

...

Keyword(s):

Bariatric Surgery ◽

Weight Loss ◽

Gray Matter ◽

Gray Matter Volume ◽

Neuropsychological Test ◽

Control Group ◽

Rapid Weight Loss ◽

Brain Health ◽

Matter Volume

Dietary modifications leading to weight loss have been suggested as a means to improve brain health. In morbid obesity, bariatric surgery (BARS)—including different procedures, such as vertical sleeve gastrectomy (VSG), gastric banding (GB), or Roux-en-Y gastric bypass (RYGB) surgery—is performed to induce rapid weight loss. Combining reduced food intake and malabsorption of nutrients, RYGB might be most effective, but requires life-long follow-up treatment. Here, we tested 40 patients before and six months after surgery (BARS group) using a neuropsychological test battery and compared them with a waiting list control group. Subsamples of both groups underwent structural MRI and were examined for differences between surgical procedures. No substantial differences between BARS and control group emerged with regard to cognition. However, larger gray matter volume in fronto-temporal brain areas accompanied by smaller volume in the ventral striatum was seen in the BARS group compared to controls. RYGB patients compared to patients with restrictive treatment alone (VSG/GB) had higher weight loss, but did not benefit more in cognitive outcomes. In sum, the data of our study suggest that BARS might lead to brain structure reorganization at long-term follow-up, while the type of surgical procedure does not differentially modulate cognitive performance.

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