Disparities in Screening for Breast Cancer Based on Limited Language Proficiency. A Retrospective Cohort Propensity Score Matched Study

2020 ◽  
Vol 231 (4) ◽  
pp. S36-S37
Author(s):  
Jose L. Cataneo ◽  
Oana A. Raicu ◽  
Klara Schwarzova ◽  
Hanna Meidl ◽  
Celeste Cruz
Keyword(s):  
Breast Cancer ◽  
Propensity Score ◽  
Language Proficiency ◽  
Retrospective Cohort ◽  
Matched Study

scholarly journals Beneficial Effect of Statins in COVID-19–Related Outcomes—Brief Report

2021 ◽  
Vol 41 (3) ◽  
Author(s):  
Hae-Young Lee ◽  
Juhee Ahn ◽  
Juhong Park ◽  
Chang Kyung Kang ◽  
Sung-Ho Won ◽  
...  
Keyword(s):  
Propensity Score ◽  
Angiotensin Converting Enzyme ◽  
Retrospective Cohort ◽  
Cox Regression ◽  
Hazard Ratio ◽  
Lipid Lowering ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme 2 ◽  
Matched Study ◽  
Related Mortality

Objective: Although statins are widely prescribed lipid-lowering drugs, there are concerns about the safety of their use in the context of coronavirus disease 2019 (COVID-19), since statins increase the expression of ACE2 (angiotensin-converting enzyme 2). This study aimed to disclose the association between statins and 60-day COVID-19 mortality. Approach and Results: All patients hospitalized with laboratory-confirmed COVID-19 were enrolled in this study from January 19 to April 16, 2020, in Korea. We evaluated the association between the use of statins and COVID-19–related mortality in the overall and the nested 1:2 propensity score–matched study. Furthermore, a comparison of the hazard ratio for death was performed between COVID-19 patients and a retrospective cohort of patients hospitalized with pneumonia between January and June 2019 in Korea. The median age of the 10 448 COVID-19 patients was 45 years. Statins were prescribed in 533 (5.1%) patients. After adjusting for age, sex, and comorbidities, Cox regression showed a significant decrease in hazard ratio associated with the use of statins (hazard ratio, 0.637 [95% CI, 0.425–0.953]; P =0.0283). Moreover, on comparing the hazard ratio between COVID-19 patients and the retrospective cohort of hospitalized pneumonia patients, the use of statins showed similar benefits. Conclusions: The use of statins correlates significantly with lower mortality in patients with COVID-19, consistent with the findings in patients with pneumonia. Graphic Abstract: A graphic abstract is available for this article.

scholarly journals Carboplatin-containing neoadjuvant chemotherapy for triple negative breast cancer (TNBC): A propensity score-matched study

2019 ◽  
Vol 30 ◽  
pp. v64-v65
Author(s):  
M.V. Dieci ◽  
C.A. Giorgi ◽  
G. Griguolo ◽  
S. Angelini ◽  
F. Miglietta ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Propensity Score ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Matched Study

scholarly journals Incidence and Outcomes of Hemorrhagic Stroke among Adults in Spain (2016–2018) According to Sex: A Retrospective, Cohort, Observational, Propensity Score Matched Study

2021 ◽  
Vol 10 (16) ◽  
pp. 3753
Author(s):  
Jose M. de Miguel-Yanes ◽  
Ana Lopez-de-Andres ◽  
Rodrigo Jimenez-Garcia ◽  
Valentin Hernandez-Barrera ◽  
Javier de Miguel-Diez ◽  
...  
Keyword(s):  
Propensity Score ◽  
Decompressive Craniectomy ◽  
Retrospective Cohort ◽  
Hemorrhagic Stroke ◽  
Antiplatelet Agents ◽  
Incidence Rates ◽  
Hospital Outcomes ◽  
Men And Women ◽  
Intracerebral Hemorrhages ◽  
Matched Study

(1) Background: We aim to analyze sex differences in the incidence, clinical characteristics and in-hospital outcomes of hemorrhagic stroke (HS) in Spain (2016–2018) using the National Hospital Discharge Database. (2) Methods: Retrospective, cohort, observational study. We estimated the incidence of HS in men and women. We analyzed comorbidity, treatments, procedures, and hospital outcomes. We matched each woman with a man by age, type of HS and medical conditions using propensity score matching. (3) Results: HS was coded in 57,227 patients aged ≥18 years (44.3% women). Overall, men showed higher incidence rates (57.3/105 vs. 43.0/105; p < 0.001; IRR = 1.60; 95% CI: 1.38–1.83). Women suffered more subarachnoid hemorrhages (25.2% vs. 14.6%), whereas men more often had intracerebral hemorrhages (55.7% vs. 54.1%). In-hospital mortality (IHM) was higher for intracerebral hemorrhage in both men and women. Women underwent decompressive craniectomy less often than men (5.0% vs. 6.2%; p < 0.001). After matching, IHM among women was higher (29.0% vs. 23.7%; p < 0.001). Increments in age, comorbidity and use of anticoagulants and antiplatelet agents prior to hospitalization were associated were higher IHM, and decompressive craniectomy was associated with lower IHM in both sexes. After multivariable adjustment, women had higher IHM (OR = 1.23; 95% CI: 1.18–1.28). (4) Conclusion: Men had higher incidence rates of HS than women. Women less often underwent decompressive craniectomy. IHM was higher among women admitted for HS than among men.

scholarly journals Antithrombotic drugs have a minimal effect on intraoperative blood loss during emergency surgery for generalized peritonitis: a nationwide retrospective cohort study in Japan

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Tadashi Matsuoka ◽  
Nao Ichihara ◽  
Hiroharu Shinozaki ◽  
Kenji Kobayashi ◽  
Alan Kawarai Lefor ◽  
...  
Keyword(s):  
Cohort Study ◽  
Propensity Score ◽  
Blood Loss ◽  
Emergency Surgery ◽  
Retrospective Cohort ◽  
Confounding Factors ◽  
Intraoperative Blood Loss ◽  
Antithrombotic Drugs ◽  
Generalized Peritonitis ◽  
Blood Loss Volume

Abstract Background The effect of antithrombotic drugs on intraoperative operative blood loss volume in patients undergoing emergency surgery for generalized peritonitis is not well defined. The purpose of this study was to investigate the effect of antithrombotic drugs on intraoperative blood loss in patients with generalized peritonitis using a nationwide surgical registry in Japan. Method This retrospective cohort study used a nationwide surgical registry data from 2011 to 2017 in Japan. Propensity score matching for the use of antithrombotic drugs was used for the adjustment of age, gender, comorbidities, frailty, preoperative state, types of surgery, surgical approach, laboratory data, and others. The main outcome was intraoperative blood loss: comparison of intraoperative blood loss, ratio of intraoperative blood loss after adjusted for confounding factors, and variable importance of all covariates. Results A total of 70,105 of the eligible 75,666 patients were included in this study, and 2947 patients were taking antithrombotic drugs. Propensity score matching yielded 2864 well-balanced pairs. The blood loss volume was slightly higher in the antithrombotic drug group (100 [10–349] vs 70 [10–299] ml). After adjustment for confounding factors, the use of antithrombotic drugs was related to a 1.30-fold increase in intraoperative blood loss compared to non-use of antithrombotic drugs (95% CI, 1.16–1.45). The variable importance revealed that the effect of the use of antithrombotic drugs was minimal compared with surgical approach or type of surgery. Conclusion This study shows that while taking antithrombotic drugs is associated with a slight increase in intraoperative blood loss in patients undergoing emergency surgery for generalized peritonitis, the effect is likely of minimal clinical significance.

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