Micromechanical poroelastic and viscoelastic properties of ex-vivo soft tissues

2020 ◽  
Vol 113 ◽  
pp. 110090
Author(s):  
Mohammad R. Islam ◽  
Jitka Virag ◽  
Michelle L. Oyen
Keyword(s):  
Viscoelastic Properties ◽  
Soft Tissues ◽  
Ex Vivo

The influence of osteopathic correction on the viscoelastic characteristics of the lower leg muscles

2019 ◽  
pp. 93-98
Author(s):  
E. M. Timanin ◽  
N. S. Sydneva ◽  
A. A. Zakharova
Keyword(s):  
Viscoelastic Properties ◽  
Gastrocnemius Muscle ◽  
Soft Tissues ◽  
Subjective Assessment ◽  
Lymphatic Drainage ◽  
Intercellular Substance ◽  
Leg Muscles ◽  
Before And After ◽  
Viscoelastic Characteristics ◽  
Instrumental Methods

Introduction. To date there is a lack of studies dedicated to the objectification of the palpation data obtained by a specialist during the osteopathic examination. The issue of the evidence of the results of osteopathic correction still remains important. Search for instrumental methods allowing to register and to measure various palpation phenomena and manifestations of somatic dysfunctions is very relevant for the development of osteopathy as a science. It is also very important to find objective characteristics of these methods.Goal of research — to study viscoelastic characteristics of the soft tissues of the lower legs by palpation and instrumental methods before and after osteopathic correction.Materials and methods. 22 volunteers (12 women and 10 men) aged 18–23 years without complaints of the musculoskeletal system were examined. Osteopathic diagnostics and measurement of the viscoelastic properties of muscles were carried out by the method of vibration viscoelastometry before and after osteopathic correction.Results. Correlation analysis by Spearman showed that the subjective assessment of an osteopath positively correlated with both elasticity (r=0,43, p<0,05) and viscosity of soft issues (r=0,29, p<0,05). For the gastrocnemius muscle, this pattern was even more pronounced — for elasticity r=0,51, p<0,05, for viscosity =0,34, p<0,05. After osteopathic correction no changes in the elasticity of the soft tissues were observed. The viscosity of the tissues reduced, but in the projection of the gastrocnemius muscle, these changes were not statistically significant (p=0,12), whereas in the projection of the soleus muscle statistically significant changes (p=0,034) were observed.Conclusion. Changes in the viscoelastic properties of tissues demonstrated that the effects of osteopathic correction with the use of myofascial mobilization techniques, articulation mobilization techniques, and lymphatic drainage techniques were not obvious. The elasticity of soft tissues of the lower legs did not change, while the viscosity decreased, especially in the projection of the soleus muscles. This effect of the osteopathic correction can be associated with the effect of thixotropy — the transformation of gel-like intercellular substance into sol. Thus, the research showed that vibration viscoelastometry can be used for the objectifi cation of the condition of soft tissues and of the effects of osteopathic correction.

scholarly journals Developing a Quantifying Device for Soft Tissue Material Prop-Erties around Lumbar Spines

Biosensors ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 67
Author(s):  
Song Joo Lee ◽  
Yong-Eun Cho ◽  
Kyung-Hyun Kim ◽  
Deukhee Lee
Keyword(s):  
Lumbar Spine ◽  
Soft Tissue ◽  
Young’S Modulus ◽  
Viscoelastic Properties ◽  
Soft Tissues ◽  
Young's Modulus ◽  
Strain Curve ◽  
Stress And Strain ◽  
Commercial Device ◽  
Tissue Material

Knowing the material properties of the musculoskeletal soft tissue could be important to develop rehabilitation therapy and surgical procedures. However, there is a lack of devices and information on the viscoelastic properties of soft tissues around the lumbar spine. The goal of this study was to develop a portable quantifying device for providing strain and stress curves of muscles and ligaments around the lumbar spine at various stretching speeds. Each sample was conditioned and applied for 20 repeatable cyclic 5 mm stretch-and-relax trials in the direction and perpendicular direction of the fiber at 2, 3 and 5 mm/s. Our device successfully provided the stress and strain curve of the samples and our results showed that there were significant effects of speed on the young’s modulus of the samples (p < 0.05). Compared to the expensive commercial device, our lower-cost device provided comparable stress and strain curves of the sample. Based on our device and findings, various sizes of samples can be measured and viscoelastic properties of the soft tissues can be obtained. Our portable device and approach can help to investigate young’s modulus of musculoskeletal soft tissues conveniently, and can be a basis for developing a material testing device in a surgical room or various lab environments.

810nm, 980nm, 1470nm and 1950nm diode laser comparison: a preliminary “ex vivo” study on oral soft tissues

2015 ◽  
Author(s):  
Carlo Fornaini ◽  
Elisabetta Merigo ◽  
Michele Sozzi ◽  
Stefano Selleri ◽  
Paolo Vescovi ◽  
...  
Keyword(s):  
Diode Laser ◽  
Soft Tissues ◽  
Ex Vivo ◽  
Ex Vivo Study

scholarly journals Correlation of Micro-Computed Tomography Assessment of Valvular Mineralisation with Histopathological and Immunohistochemical Features of Calcific Aortic Valve Disease

2019 ◽  
Vol 9 (1) ◽  
pp. 29
Author(s):  
Guillermo Solache-Berrocal ◽  
Ana María Barral-Varela ◽  
Sheila Areces-Rodríguez ◽  
Alejandro Junco-Vicente ◽  
Aitana Vallina-Álvarez ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Aortic Valve ◽  
Molecular Mechanisms ◽  
Soft Tissues ◽  
Ex Vivo ◽  
Developed Countries ◽  
Macrophage Infiltration ◽  
Micro Computed Tomography ◽  
Calcific Aortic Valve Disease ◽  
Calcium Deposits

Aortic valve stenosis is a serious disease with increasing prevalence in developed countries. Research aimed at uncovering the molecular mechanisms behind its main cause, aortic valve calcification, is thus crucial for the development of future therapies. It is frequently difficult to measure the extent of mineralisation in soft tissues and some methods require the destruction of the sample. Micro-computed tomography (µCT), a non-destructive technique, was used to quantify the density and volume of calcium deposits on cusps from 57 explanted aortic valves. Conventional and immunostaining techniques were used to characterise valve tissue degeneration and the inflammatory and osteogenic stage with several markers. Although most of the analysed cusps came from severe stenosis patients, the µCT parameter bone volume/tissue volume ratio distinguished several degrees of mineralisation that correlated with the degree of structural change in the tissue and the amount of macrophage infiltration as determined by CD68 immunohistochemistry. Interestingly, exosomal markers CD63 and Alix co-localised with macrophage infiltration surrounding calcium deposits, suggesting that those vesicles could be produced at least in part by these immune cells. In conclusion, we have shown that the ex vivo assessment of aortic valve mineralisation with µCT reflects the molecular and cellular changes in pathological valves during progression towards stenosis. Thus, our results give additional validity to quantitative μCT as a convenient laboratory tool for basic research on this type of cardiovascular calcification.

scholarly journals Early fracture callus displays smooth muscle-like viscoelastic properties ex vivo: Implications for fracture healing

2009 ◽  
Vol 27 (11) ◽  
pp. 1508-1513 ◽  
Author(s):  
Stuart J. McDonald ◽  
Philip C. Dooley ◽  
Aaron C. McDonald ◽  
Johannes A. Schuijers ◽  
Alex R. Ward ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Fracture Healing ◽  
Viscoelastic Properties ◽  
Ex Vivo ◽  
Fracture Callus

scholarly journals Evaluation of Electrospun Nanofiber-Anchored Silicone for the Degenerative Intervertebral Disc

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
M. Khandaker ◽  
S. Riahanizad
Keyword(s):  
Intervertebral Disc ◽  
Viscoelastic Properties ◽  
Mechanical Stability ◽  
Ex Vivo ◽  
Electrospun Fiber ◽  
Mechanical Tests ◽  
Tissue Properties ◽  
Clinical Potential ◽  
Fiber Mesh ◽  
Mesh Anchoring

The nucleus pulposus (NP) substitution by polymeric gel is one of the promising techniques for the repair of the degenerative intervertebral disc (IVD). Silicone gel is one of the potential candidates for a NP replacement material. Electrospun fiber anchorage to silicone disc, referred as ENAS disc, may not only improve the biomechanical performances of the gel but it can also improve restoration capability of the gel, which is unknown. This study successfully produced a novel process to anchor any size and shape of NP gel with electrospun fiber mesh. Viscoelastic properties of silicone and ENAS disc were measured using standard experimental techniques and compared with the native tissue properties. Ex vivo mechanical tests were conducted on ENAS disc-implanted rabbit tails to the compare the mechanical stability between intact and ENAS implanted spines. This study found that viscoelastic properties of ENAS disc are higher than silicone disc and comparable to the viscoelastic properties of human NP. The ex vivo studies found that the ENAS disc restore the mechanical functionality of rabbit tail spine, after discectomy of native NP and replacing the NP by ENAS disc. Therefore, the PCL ENF mesh anchoring technique to a NP implant can have clinical potential.

scholarly journals Reflection-Mode Ultrasound Computed Tomography Based on Wavelet Processing for High-Contrast Anatomical and Morphometric Imaging

2021 ◽  
Vol 11 (20) ◽  
pp. 9368
Author(s):  
Elise Doveri ◽  
Laurent Sabatier ◽  
Vincent Long ◽  
Philippe Lasaygues
Keyword(s):  
Computed Tomography ◽  
Soft Tissues ◽  
Ex Vivo ◽  
Ultrasonic Waves ◽  
Reflection Mode ◽  
Coded Excitation ◽  
Ultrasonic Signals ◽  
Ultrasound Computed Tomography ◽  
Slice Imaging ◽  
Transverse Slice

Medical B-mode ultrasound is widely used for the examination of children’s limbs, including soft tissue, muscle, and bone. However, for the accurate examination of the bone only, it is often replaced by more restrictive clinical modalities. Several authors have investigated ultrasonic imaging of bone to assess cortical thickness and/or to estimate the wave velocity through the internal structure. The present work focuses on the transverse slice imaging process using reflection-mode ultrasound computed tomography (USCT). The method is valid for imaging soft tissues with similar acoustic impedances, but in the presence of bone, the higher contrasts alter the propagation of ultrasonic waves and reduce the contrast-to-noise ratio (CNR). There is a need to change the methods used for the processing of ultrasonic signals. Our group has developed a wavelet-based coded excitation (WCE) method to process information in frequency and time. The objective of this study is to use the method to improve reflection-mode USCT, at low ultrasonic intensities, to better address organ morphometry. Experimental results on a newborn arm phantom and on an ex vivo chicken drumstick are presented, and the usefulness of this WCE-mode USCT is discussed.

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