Studies are going worldwide to develop an effective method for treatment against the global pandemic of COVID-19 but unfortunately no treatment method has been declared as a specific therapeutic approach against COVID-19. History stands as evidence where homeopathy intervention has been beneficial in both preventive and curative aspects of various epidemics. Holistic symptomatological aspect based on generalities enables Homeopathy to be effective in any disease condition. Selection of homeopathic remedy is always on basis of the totality of symptoms and in most cases the changes occurring in cellular and molecular level are not required except in few occasions of dose and potency determination. This concept of healing through homoeopathy is different from other conventional methods of treatment where molecular pathogenesis is the fulcrum of the drug protocols. Hence, in the era of fight to discover vaccine against COVID-19, the following case report shows how a COVID-19 positive individual with mild symptomatology of vomiting, fever, malaise, heaviness of head and loss of taste, recovers with prescription of Bryonia alba 200, followed by Tuberculinum 200, 1M and 10M and at the same time RT-PCR for SARS-CoV-2 becomes negative in the duration of two weeks. Therefore, this case report demonstrates why Homoeopathic intervention should be emphasized in the management of this international crisis. Keywords Coronavirus disease; Bryonia; Tuberculinum; RT-PCR