Contribution of high resolution peripheral quantitative CT to the management of bone and joint diseases

Abstract Bone health in children with osteogenesis imperfecta is monitored using radiographs and dual-energy X-ray absorptiometry, which have limitations. High-resolution peripheral quantitative CT can non-invasively derive bone microarchitectural data. Children with severe osteogenesis imperfecta have fragile deformed bones, and positioning for this scan can be difficult. We assessed the feasibility of high-resolution peripheral quantitative CT in nine children aged 9–15 years with osteogenesis imperfecta and compared results with dual-energy X-ray absorptiometry and with healthy controls. All nine recruited children were successfully scanned and showed no preference for either modality. It therefore appears feasible to perform high-resolution peripheral quantitative CT in children with osteogenesis imperfecta aged 9 years and older. Future studies should focus on understanding the clinical implications of the technology in this patient cohort.

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Visual detection of cortical breaks in hand joints: reliability and validity of high-resolution peripheral quantitative CT compared to microCT

BMC Musculoskeletal Disorders ◽

10.1186/s12891-016-1148-y ◽

2016 ◽

Vol 17 (1) ◽

Cited By ~ 12

Author(s):

A. Scharmga ◽

M. Peters ◽

A. van Tubergen ◽

J. van den Bergh ◽

J. de Jong ◽

...

Keyword(s):

High Resolution ◽

Visual Detection ◽

Reliability And Validity ◽

Quantitative Ct ◽

Hand Joints

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The interobserver reliability of the diagnosis and classification of scaphoid fractures using high-resolution peripheral quantitative CT

The Bone & Joint Journal ◽

10.1302/0301-620x.102b4.bjj-2019-0632.r3 ◽

2020 ◽

Vol 102-B (4) ◽

pp. 478-484 ◽

Cited By ~ 2

Author(s):

Anne M. Daniels ◽

Caroline E. Wyers ◽

Heinrich M. J. Janzing ◽

Sander Sassen ◽

Daan Loeffen ◽

...

Keyword(s):

High Resolution ◽

Interobserver Agreement ◽

Interobserver Reliability ◽

Scaphoid Fracture ◽

Intraclass Correlation ◽

Correlation Coefficients ◽

Kappa Statistics ◽

Quantitative Ct ◽

Scaphoid Fractures

Aims Besides conventional radiographs, the use of MRI, CT, and bone scintigraphy is frequent in the diagnosis of a fracture of the scaphoid. However, which techniques give the best results remain unknown. The investigation of a new imaging technique initially requires an analysis of its precision. The primary aim of this study was to investigate the interobserver agreement of high-resolution peripheral quantitative CT (HR-pQCT) in the diagnosis of a scaphoid fracture. A secondary aim was to investigate the interobserver agreement for the presence of other fractures and for the classification of scaphoid fracture. Methods Two radiologists and two orthopaedic trauma surgeons evaluated HR-pQCT scans of 31 patients with a clinically-suspected scaphoid fracture. The observers were asked to determine the presence of a scaphoid or other fracture and to classify the scaphoid fracture based on the Herbert classification system. Fleiss kappa statistics were used to calculate the interobserver agreement for the diagnosis of a fracture. Intraclass correlation coefficients (ICCs) were used to assess the agreement for the classification of scaphoid fracture. Results A total of nine (29%) scaphoid fractures and 12 (39%) other fractures were diagnosed in 20 patients (65%) using HR-pQCT across the four observers. The interobserver agreement was 91% for the identification of a scaphoid fracture (95% confidence interval (CI) 0.76 to 1.00) and 80% for other fractures (95% CI 0.72 to 0.87). The mean ICC for the classification of a scaphoid fracture in the seven patients diagnosed with scaphoid fracture by all four observers was 73% (95% CI 0.42 to 0.94). Conclusion We conclude that the diagnosis of scaphoid and other fractures is reliable when using HR-pQCT in patients with a clinically-suspected fracture. Cite this article: Bone Joint J 2020;102-B(4):478–484.

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FRI0538 Validation of A Semi-Automatic Algorithm for Defining Cortical Breaks in Finger Joints Using High-Resolution Peripheral Quantitative CT by Microct

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2016-eular.1627 ◽

2016 ◽

Vol 75 (Suppl 2) ◽

pp. 634.2-635

Author(s):

M. Peters ◽

A. Scharmga ◽

A. van Tubergen ◽

B. van Rietbergen ◽

R. Weyers ◽

...

Keyword(s):

High Resolution ◽

Quantitative Ct ◽

Finger Joints ◽

Automatic Algorithm

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Osteonecrosis diagnosed on MR images of the knee: Relationship to reduced bone mineral density determined by high resolution peripheral quantitative CT

Acta Radiologica ◽

10.1080/j.1600-0455.2003.00108.x ◽

2003 ◽

Vol 44 (5) ◽

pp. 525-531 ◽

Cited By ~ 2

Author(s):

M. Zanetti ◽

J. Romero ◽

M. A. Dambacher ◽

J. Hodler

Keyword(s):

Bone Mineral Density ◽

High Resolution ◽

Distal Radius ◽

Bone Mineral ◽

Insufficiency Fracture ◽

Mr Images ◽

Mineral Density ◽

Quantitative Ct ◽

Tibial Condyle ◽

The Mean

Purpose: To evaluate if osteonecrosis diagnosed on MR images of the knee relates to reduced bone mineral density (BMD) and may be caused by an insufficiency fracture. Material and Methods: Thirty-two consecutive patients (8 men, 24 women; age range 27–82 years, mean 62 years) with MR findings of osteonecrosis of the femoral or tibial condyle were prospectively included. Trabecular and cortical BMD were measured with high resolution peripheral quantitative CT in the non-dominant distal radius and the tibia of the involved extremity. One tibia was not measured due to posttraumatic deformity. Results: The mean trabecular BMD of the radius was 81% of the young-adult average peak BMD (range 19–160%). The mean cortical BMD in the radius was 86% (range 63–108%). The mean trabecular BMD in the tibia was 92% (range 28–160%). The mean cortical BMD in the tibia was 86% (range 49–132%). The values of the trabecular bone of the distal radius (tibia) were normal in 11 (15) patients, osteopenic in 12 (4), and osteoporotic in 9 (12), respectively. The cortical bone values of the distal radius (tibia) were normal in 12 (13) patients, osteopenic in 12 (12), and osteoporotic in 8 (6), respectively. Conclusion: Osteoporosis and osteopenia are commonly found in patients with osteonecrosis of the knee as diagnosed on MR images. This indicates that for some patients an insufficiency mechanism may be responsible for the MR findings. However, in the patients with normal bone density other reasons for osteonecrosis may be present.

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