scholarly journals Charge variants characterization of a monoclonal antibody by ion exchange chromatography coupled on-line to native mass spectrometry: Case study after a long-term storage at +5 °C

2017 ◽  
Vol 1048 ◽  
pp. 130-139 ◽  
Author(s):  
Y. Leblanc ◽  
C. Ramon ◽  
N. Bihoreau ◽  
G. Chevreux
2021 ◽  
Vol 67 (No. 5) ◽  
pp. 195-203
Author(s):  
Dalibor Šafařík ◽  
Petra Hlaváčková ◽  
David Březina

The aim of the article is to describe the issue of determining the characteristics and parameters of raw timber natural losses due to shrinkage at long-term storage, defining the theoretical basis for creating standards, and verify its finding by means of a case study in raw timber storing. This issue is very topical in forestry practice in the Czech Republic as well as in other countries. The lower and upper limits of the standards were calculated, and the proposed mean value was grouped according to woody plants that reflected the most frequent commercial usage with respect to subsequent processing. Subsequently, experimental verification was carried out on a representative sample of 2 209.99 m3 of raw timber of Norway spruce (Picea abies /L./ H. Karst.) at selected forest administrations. Furthermore, the article addresses the related accounting and tax issues of the standards of natural losses of raw timber. Currently, no legislation mandates an entity to establish standards.


2005 ◽  
Vol 1 ◽  
pp. 117693510500100 ◽  
Author(s):  
Breeana L Mitchell ◽  
Yutaka Yasui ◽  
Christopher I Li ◽  
Annette L. Fitzpatrick ◽  
Paul D Lampe

Mass spectrometry approaches to biomarker discovery in human fluids have received a great deal of attention in recent years. While mass spectrometry instrumentation and analysis approaches have been widely investigated, little attention has been paid to how sample handling can impact the plasma proteome and therefore influence biomarker discovery. We have investigated the effects of two main aspects of sample handling on MALDI-TOF data: repeated freeze-thaw cycles and the effects of long-term storage of plasma at –70°C. Repeated freeze-thaw cycles resulted in a trend towards increasing changes in peak intensity, particularly after two thaws. However, a 4-year difference in long-term storage appears to have minimal effect on protein in plasma as no differences in peak number, mass distribution, or coefficient of variation were found between samples. Therefore, limiting freeze/thaw cycles seems more important to maintaining the integrity of the plasma proteome than degradation caused by long-term storage at –70°C.


2021 ◽  
Vol 14 (1) ◽  
pp. 96-105
Author(s):  
V. V. Suskin ◽  
◽  
I. V. Kapyrin ◽  
F. V. Grigorev ◽  
◽  
...  

The article evaluates the impact of a “buried wall” barrier on the long-term safety during the long-term storage1 or in-situ disposal of nuclear legacy facilities, in particular, industrial reservoirs, as well as during the development of near-surface disposal facilities for radioactive waste (RWDF). For assessment purposes, filtration and mass transfer processes have been numerically modelled in the GeRa code based on a case study of a reference near-surface facility. The study explores in which way the available covering screen affects the dynamics of contaminant spread. It evaluates the sensitivity of the results to the dispersion parameter commonly characterized by a high degree of uncertainty.


2014 ◽  
Vol 321 ◽  
pp. 475-480 ◽  
Author(s):  
O.B. Nazarenko ◽  
Yu.A. Amelkovich ◽  
A.I. Sechin

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