Chemotaxis-based smart drug delivery of epirubicin using a 3D printed microfluidic chip

2021 ◽  
Vol 1162 ◽  
pp. 122456
Author(s):  
Kolsoum Dalvand ◽  
A. Ghiasvand ◽  
Vipul Gupta ◽  
Brett Paull
Keyword(s):  
Drug Delivery ◽  
Microfluidic Chip ◽  
3D Printed ◽  
Smart Drug ◽  
Smart Drug Delivery

scholarly journals 4D Printing: The Dawn of “Smart” Drug Delivery Systems and Biomedical Applications

2021 ◽  
Vol 11 (5-S) ◽  
pp. 131-137
Author(s):  
Ahmar Khan ◽  
Mir Javid Iqbal ◽  
Saima Amin ◽  
Humaira Bilal ◽  
, Bilquees ◽  
...  
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Patient Compliance ◽  
Smart Materials ◽  
Healthcare Sector ◽  
Massachusetts Institute Of Technology ◽  
4D Printing ◽  
3D Printed ◽  
Smart Drug ◽  
Smart Drug Delivery

With the approval of first 3D printed drug “spritam” by USFDA, 3D printing is gaining acceptance in healthcare, engineering and other aspects of life. Taking 3D printing towards the next step gives birth to what is referred to as “4D printing”. The full credit behind the unveiling of 4D printing technology in front of the world goes to Massachusetts Institute of Technology (MIT), who revealed “time” in this technology as the fourth dimension.  4D printing is a renovation of 3D printing wherein special materials (referred to as smart materials) are incorporated which change their morphology post printing in response to a stimulus. Depending upon the applicability of this technology, there may be a variety of stimuli, most common among them being pH, water, heat, wind and other forms of energy.  The upper hand of 4D printing over 3D printing is that 3D printed structures are generally immobile, rigid and inanimate whereas 4D printed structures are flexible, mobile and able to interact with the surrounding environment based on the stimulus. This capability of 4D printing to transform 3D structures into smart structures in response to various stimuli promises a great potential for biomedical and bioengineering applications. The potential of 4D printing in developing pre-programmed biomaterials that can undergo transformations lays new foundations for enabling smart pharmacology, personalized medicine, and smart drug delivery, all of which can help in combating diseases in a smarter way. Hence, the theme of this paper is about the potential of 4D printing in creating smart drug delivery, smart pharmacology, targeted drug delivery and better patient compliance. The paper highlights the recent advancements of 4D printing in healthcare sector and ways by which 4D printing is doing wonders in creating smart drug delivery and tailored medicine. The major constraints in the approach have also been highlighted. Keywords: 4D printing, smart, drug delivery system, patient compliance, biomaterials, tailored medicine

Adult Stem Cells and Biocompatible Scaffolds as Smart Drug Delivery Tools for Cardiac Tissue Repair

2013 ◽  
Vol 20 (28) ◽  
pp. 3429-3447 ◽  
Author(s):  
Stefania Pagliari ◽  
Sara Romanazzo ◽  
Diogo Mosqueira ◽  
Perpetua Pinto-do-O ◽  
Takao Aoyagi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Stem Cells ◽  
Tissue Repair ◽  
Adult Stem Cells ◽  
Cardiac Tissue ◽  
Smart Drug ◽  
Smart Drug Delivery

Advances in Nanoparticles as Anticancer Drug Delivery Vector: Need of this Century

2020 ◽  
Vol 26 (15) ◽  
pp. 1637-1649 ◽  
Author(s):  
Imran Ali ◽  
Sofi D. Mukhtar ◽  
Heyam S. Ali ◽  
Marcus T. Scotti ◽  
Luciana Scotti
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Medical Science ◽  
Drug Carriers ◽  
Anticancer Drug Delivery ◽  
Ph Values ◽  
Delivery Vector ◽  
Future Challenges ◽  
Smart Drug ◽  
Smart Drug Delivery

Background: Nanotechnology has contributed a great deal to the field of medical science. Smart drugdelivery vectors, combined with stimuli-based characteristics, are becoming increasingly important. The use of external and internal stimulating factors can have enormous benefits and increase the targeting efficiency of nanotechnology platforms. The pH values of tumor vascular tissues are acidic in nature, allowing the improved targeting of anticancer drug payloads using drug-delivery vectors. Nanopolymers are smart drug-delivery vectors that have recently been developed and recommended for use by scientists because of their potential targeting capabilities, non-toxicity and biocompatibility, and make them ideal nanocarriers for personalized drug delivery. Method: The present review article provides an overview of current advances in the use of nanoparticles (NPs) as anticancer drug-delivery vectors. Results: This article reviews the molecular basis for the use of NPs in medicine, including personalized medicine, personalized therapy, emerging vistas in anticancer therapy, nanopolymer targeting, passive and active targeting transports, pH-responsive drug carriers, biological barriers, computer-aided drug design, future challenges and perspectives, biodegradability and safety. Conclusions: This article will benefit academia, researchers, clinicians, and government authorities by providing a basis for further research advancements.

Multi-responsive core-crosslinked poly (thiolether ester) micelles for smart drug delivery

Polymer ◽  
2017 ◽  
Vol 110 ◽  
pp. 235-241 ◽  
Author(s):  
Yanfang Hu ◽  
Ming Deng ◽  
Huailin Yang ◽  
Li Chen ◽  
Chunsheng Xiao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Smart Drug ◽  
Smart Drug Delivery

Diatom mediated smart drug delivery system

2021 ◽  
Vol 63 ◽  
pp. 102433
Author(s):  
Sakshi Phogat ◽  
Abhishek Saxena ◽  
Neha Kapoor ◽  
Charu Aggarwal ◽  
Archana Tiwari
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Smart Drug ◽  
Smart Drug Delivery

scholarly journals Erratum: Corrigendum: Doxorubicin-loaded platelets as a smart drug delivery system: An improved therapy for lymphoma

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Peipei Xu ◽  
Huaqin Zuo ◽  
Bing Chen ◽  
Ruju Wang ◽  
Arsalan Ahmed ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Smart Drug ◽  
Smart Drug Delivery

Bicontinuous, Thermoresponsive, L3-Phase Silica Nanocomposites and Their Smart Drug-Delivery Applications

2005 ◽  
Vol 17 (5) ◽  
pp. 634-637 ◽  
Author(s):  
J. H. Chang ◽  
C. H. Shim ◽  
B. J. Kim ◽  
Y. Shin ◽  
G. J. Exarhos ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Silica Nanocomposites ◽  
Drug Delivery Applications ◽  
Smart Drug ◽  
Smart Drug Delivery

scholarly journals Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1285
Author(s):  
Louise Van Gheluwe ◽  
Igor Chourpa ◽  
Coline Gaigne ◽  
Emilie Munnier
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Ex Vivo ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Smart Drug ◽  
Smart Drug Delivery

Progress in recent years in the field of stimuli-responsive polymers, whose properties change depending on the intensity of a signal, permitted an increase in smart drug delivery systems (SDDS). SDDS have attracted the attention of the scientific community because they can help meet two current challenges of the pharmaceutical industry: targeted drug delivery and personalized medicine. Controlled release of the active ingredient can be achieved through various stimuli, among which are temperature, pH, redox potential or even enzymes. SDDS, hitherto explored mainly in oncology, are now developed in the fields of dermatology and cosmetics. They are mostly hydrogels or nanosystems, and the most-used stimuli are pH and temperature. This review offers an overview of polymer-based SDDS developed to trigger the release of active ingredients intended to treat skin conditions or pathologies. The methods used to attest to stimuli-responsiveness in vitro, ex vivo and in vivo are discussed.

Sign in / Sign up

Export Citation Format

Share Document