Targeting Cancer Cell Adhesion Molecule, CD146, with Low-Dose Gold Nanorods and Mild Hyperthermia Disrupts Actin Cytoskeleton and Cancer Cell Migration

2021 ◽  
Author(s):  
Jinyuan Liu ◽  
Lin Kang ◽  
Ishara Ratnayake ◽  
Phil Ahrenkiel ◽  
Steve Smith ◽  
...  
Keyword(s):  
Cell Migration ◽  
Cell Adhesion ◽  
Cancer Cell ◽  
Adhesion Molecule ◽  
Gold Nanorods ◽  
Cell Adhesion Molecule ◽  
Low Dose ◽  
Cancer Cell Migration ◽  
Mild Hyperthermia ◽  
Cancer Cell Adhesion

scholarly journals Functional N-methyl-D-aspartate receptors in O-2A glial precursor cells: a critical role in regulating polysialic acid-neural cell adhesion molecule expression and cell migration.

1996 ◽  
Vol 135 (6) ◽  
pp. 1565-1581 ◽  
Author(s):  
C Wang ◽  
W F Pralong ◽  
M F Schulz ◽  
G Rougon ◽  
J M Aubry ◽  
...  
Keyword(s):  
Cell Migration ◽  
Cell Adhesion ◽  
Nmda Receptor ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Polysialic Acid ◽  
Neural Cell ◽  
Adhesion Molecule Expression ◽  
Neural Cell Adhesion

The capacity for long-distance migration of the oligodendrocyte precursor cell, oligodendrocyte-type 2 astrocyte (O-2A), is essential for myelin formation. To study the molecular mechanisms that control this process, we used an in vitro migration assay that uses neurohypophysial explants. We provide evidence that O-2A cells in these preparations express functional N-methyl-D-aspartate (NMDA) receptors, most likely as homomeric complexes of the NR1 subunit. We show that NMDA evokes an increase in cytosolic Ca2+ that can be blocked by the NMDA receptor antagonist AP-5 and by Mg2+. Blocking the activity of these receptors dramatically diminished O-2A cell migration from explants. We also show that NMDA receptor activity is necessary for the expression by O-2A cells of the highly sialylated polysialic acid-neural cell adhesion molecule (PSA-NCAM) that is required for their migration. Thus, glutamate or glutamate receptor ligands may regulate O-2A cell migration by modulating expression of PSA-NCAM. These studies demonstrate how interactions between ionotropic receptors, intracellular signaling, and cell adhesion molecule expression influence cell surface properties, which in turn are critical determinants of cell migration.

Activated leukocyte cell adhesion molecule (ALCAM/CD166): Signaling at the divide of melanoma cell clustering and cell migration?

2005 ◽  
Vol 24 (2) ◽  
pp. 223-236 ◽  
Author(s):  
Guido W. M. Swart ◽  
Pim C. Lunter ◽  
Jeroen W. J. van Kilsdonk ◽  
Leon C. L. T. van Kempen
Keyword(s):  
Cell Migration ◽  
Cell Adhesion ◽  
Melanoma Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Cell Clustering
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