Tumor acidity-activatable photothermal/Fenton nanoagent for synergistic therapy

2021 ◽  
Author(s):  
Zhe Yang ◽  
Li Zhang ◽  
Jielin Wei ◽  
Ruiqi Li ◽  
Qi Xu ◽  
...  
Keyword(s):  
Tumor Acidity

Cisplatin Resistance Reversal of Lung Cancers by Tumor Acidity-Activable Vesicular Nanoreactors via Tumor Oxidative Stress Amplification

2021 ◽  
Author(s):  
Jean Felix Mukerabigwi ◽  
Yu Han ◽  
Nannan Lu ◽  
Wendong Ke ◽  
Yuheng Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Drug Resistance ◽  
Therapeutic Efficacy ◽  
Cisplatin Resistance ◽  
Clinical Applications ◽  
Lung Cancers ◽  
Resistance Reversal ◽  
Tumor Acidity ◽  
Stress Amplification ◽  
Novel Strategy

Drug resistance of cisplatin significantly limits its therapeutic efficacy in clinical applications against a variety of cancers. Herein, we develop a novel strategy to overcome cisplatin drug resistance through sensitizing...

scholarly journals Tumor acidity-induced charge-reversal liposomal doxorubicin with enhanced cancer cell uptake and anticancer activity

Giant ◽  
2021 ◽  
Vol 6 ◽  
pp. 100052 ◽  
Author(s):  
Jinpeng Yang ◽  
Zihe Yin ◽  
Yincheng Chang ◽  
Hua Wang ◽  
Jiang-Fei Xu ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Cancer Cell ◽  
Liposomal Doxorubicin ◽  
Cell Uptake ◽  
Charge Reversal ◽  
Tumor Acidity ◽  
Induced Charge

Tumor Acidity-Sensitive Polymeric Vector for Active Targeted siRNA Delivery

2015 ◽  
Vol 137 (48) ◽  
pp. 15217-15224 ◽  
Author(s):  
Chun-Yang Sun ◽  
Song Shen ◽  
Cong-Fei Xu ◽  
Hong-Jun Li ◽  
Yang Liu ◽  
...  
Keyword(s):  
Sirna Delivery ◽  
Tumor Acidity

Sheddable Ternary Nanoparticles for Tumor Acidity-Targeted siRNA Delivery

ACS Nano ◽  
2011 ◽  
Vol 6 (1) ◽  
pp. 771-781 ◽  
Author(s):  
Xian-Zhu Yang ◽  
Jin-Zhi Du ◽  
Shuang Dou ◽  
Cheng-Qiong Mao ◽  
Hong-Yan Long ◽  
...  
Keyword(s):  
Sirna Delivery ◽  
Tumor Acidity

Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels

2014 ◽  
Vol 50 (58) ◽  
pp. 7824-7827 ◽  
Author(s):  
Minghui Zan ◽  
Junjie Li ◽  
Shizhong Luo ◽  
Zhishen Ge
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
High Efficiency ◽  
Delivery Systems ◽  
Ph Responsive ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
Lysosomal Ph ◽  
Tumor Acidity

The multistage polymeric nanogel delivery systems were constructed via host–guest interactions, which showed tumor acidity-triggered disassembly into smaller nanoparticles for deep tissue penetration, high-efficiency cellular uptake, and intracellular endo-lysosomal pH-responsive drug release.

scholarly journals Tumor-acidity activated surface charge conversion of two-photon fluorescent nanoprobe for enhanced cellular uptake and targeted imaging of intracellular hydrogen peroxide

2019 ◽  
Vol 10 (40) ◽  
pp. 9351-9357 ◽  
Author(s):  
Lanlan Chen ◽  
Shuai Xu ◽  
Wei Li ◽  
Tianbing Ren ◽  
Lin Yuan ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Surface Charge ◽  
Cellular Uptake ◽  
Targeted Imaging ◽  
Two Photon ◽  
Fluorescent Nanoprobe ◽  
Tumor Acidity ◽  
Ph Dependent ◽  
Intracellular Hydrogen Peroxide ◽  
Activated Surface

A smart, two-photon fluorescent GC–NABP nanoprobe with pH-dependent surface charge conversion was developed for tumor-targeted visualization of H2O2.

Tumor acidity, ion trapping and chemotherapeutics

2003 ◽  
Vol 66 (7) ◽  
pp. 1207-1218 ◽  
Author(s):  
Brent P. Mahoney ◽  
Natarajan Raghunand ◽  
Brenda Baggett ◽  
Robert J. Gillies
Keyword(s):  
Ion Trapping ◽  
Tumor Acidity

Robust Anticancer Efficacy of a Biologically Synthesized Tumor Acidity-Responsive and Autophagy-Inducing Functional Beclin 1

2018 ◽  
Vol 10 (6) ◽  
pp. 5227-5239 ◽  
Author(s):  
Guo-Bin Ding ◽  
Junqing Sun ◽  
Gengfeng Wu ◽  
Binchun Li ◽  
Peng Yang ◽  
...  
Keyword(s):  
Beclin 1 ◽  
Anticancer Efficacy ◽  
Tumor Acidity

scholarly journals Exploiting Tumor Acidity in Designing a Novel Cancer Targeting Agent

2017 ◽  
Vol 112 (3) ◽  
pp. 450a-451a
Author(s):  
Chitrak Gupta ◽  
Blake Mertz
Keyword(s):  
Cancer Targeting ◽  
Tumor Acidity
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