Galactose Conjugated boron dipyrromethene and Hydrogen Bonding Promoted J-aggregates for Efficiently Targeted NIR-II Fluorescence Assistant Photothermal Therapy

Exploiting cyanine dye J-aggregates/monomer equilibrium in hydrophobic protein pockets for efficient multi-step phototherapy: An innovative concept for smart nanotheranostics

Nanoscale ◽

10.1039/d0nr09058a ◽

2021 ◽

Author(s):

Matias Luis Picchio ◽

Julian Bergueiro Álvarez ◽

Stefanie Wedepohl ◽

Roque J Minari ◽

Cecilia Ines Alvarez Igarzabal ◽

...

Keyword(s):

Indocyanine Green ◽

Contrast Agent ◽

Photothermal Therapy ◽

Near Infrared ◽

Cyanine Dye ◽

Hydrophobic Protein ◽

Nir Dyes ◽

Protein Pockets ◽

J Aggregates ◽

Innovative Concept

After several decades of development in the field of near-infrared (NIR) dyes for photothermal therapy (PTT), indocyanine green (ICG) still remains the only FDA-approved NIR contrast agent. However, upon NIR...

Download Full-text

A three-dimensional BODIPY–iron(iii) compound with improved H2O2-response for NIR-II photoacoustic imaging guided chemodynamic/photothermal therapy

Chemical Communications ◽

10.1039/d0cc01164a ◽

2020 ◽

Vol 56 (46) ◽

pp. 6281-6284 ◽

Cited By ~ 4

Author(s):

Changjin Ou ◽

Yewei Zhang ◽

Wei Ge ◽

Liping Zhong ◽

Yong Huang ◽

...

Keyword(s):

Coordination Polymer ◽

Cancer Cells ◽

Photothermal Therapy ◽

Photoacoustic Imaging ◽

Three Dimensional ◽

Polymer Nanoparticles ◽

Boron Dipyrromethene

3D boron dipyrromethene (BODIPY)–Fe(iii) coordination polymer nanoparticles with NIR-II absorption were developed as photothermal and chemodynamic agent to effectively kill cancer cells.

Download Full-text

Recent Progress in Hydrogen-Bonded π-Conjugated Systems Displaying J-Type Aggregates

Organic Materials ◽

10.1055/s-0040-1708502 ◽

2020 ◽

Vol 02 (01) ◽

pp. 047-063 ◽

Cited By ~ 4

Author(s):

Nelson Ricardo Ávila-Rovelo ◽

Amparo Ruiz-Carretero

Keyword(s):

Hydrogen Bonding ◽

Self Assembly ◽

Noncovalent Interactions ◽

Functional Materials ◽

Organic Electronic Devices ◽

Conjugated Systems ◽

Hydrogen Bonding Interactions ◽

Different Types ◽

J Aggregates ◽

Additional Hydrogen

Supramolecular approaches are of great interest in the design of functional materials. The types of aggregates arising from different noncovalent interactions endow materials with intriguing properties. In this sense, J-type aggregates are very attractive due to their unique optical properties and capacity to transport excitons. These features make them great candidates in the design of materials for organic electronic devices. Furthermore, the incorporation of additional hydrogen-bonding functionalities provides J-aggregates with superior directionality and connection among the different π-conjugated cores. The control over the formation of H-bonds to achieve functional aggregates is therefore a promising strategy towards controlled structures with specific functions.This review outlines the most relevant and recent works of π-conjugated systems exhibiting J-type aggregates resulting from hydrogen-bonding interactions. Different types of hydrogen-bonding functionalities will be discussed together with their roles in the aggregate properties, their impact in the optoelectronic properties, the self-assembly mechanisms, and their applications in organic electronics.

Download Full-text

J‐Aggregates of Organic Dye Molecules Complexed with Iron Oxide Nanoparticles for Imaging‐Guided Photothermal Therapy Under 915‐nm Light

Small ◽

10.1002/smll.202007013 ◽

2021 ◽

Vol 17 (2) ◽

pp. 2007013

Author(s):

Xuejiao Song ◽

Hua Gong ◽

Teng Liu ◽

Liang Cheng ◽

Chao Wang ◽

...

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Photothermal Therapy ◽

Organic Dye ◽

Oxide Nanoparticles ◽

Dye Molecules ◽

J Aggregates

Download Full-text

J-Aggregates of Organic Dye Molecules Complexed with Iron Oxide Nanoparticles for Imaging-Guided Photothermal Therapy Under 915-nm Light

Small ◽

10.1002/smll.201401025 ◽

2014 ◽

pp. n/a-n/a ◽

Cited By ~ 27

Author(s):

Xuejiao Song ◽

Hua Gong ◽

Teng Liu ◽

Liang Cheng ◽

Chao Wang ◽

...

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Photothermal Therapy ◽

Organic Dye ◽

Oxide Nanoparticles ◽

Dye Molecules ◽

J Aggregates

Download Full-text

Self-destructive PEG–BODIPY nanomaterials for photodynamic and photothermal therapy

Journal of Materials Chemistry B ◽

10.1039/c9tb00752k ◽

2019 ◽

Vol 7 (30) ◽

pp. 4655-4660 ◽

Cited By ~ 8

Author(s):

Chaonan Li ◽

Wenhai Lin ◽

Shi Liu ◽

Wei Zhang ◽

Zhigang Xie

Keyword(s):

Reactive Oxygen Species ◽

Ethylene Glycol ◽

Photothermal Therapy ◽

Reactive Oxygen ◽

Oxygen Species ◽

Poly Ethylene Glycol ◽

Boron Dipyrromethene ◽

Poly Ethylene

Amphiphilic photosensitizers are made from boron dipyrromethene and poly(ethylene glycol) by using a thioketal linker, which is reactive oxygen species-responsive for photodynamic and photothermal therapy.

Download Full-text

Self-Assembly of Hybrid Photosensitizer for Synergistically Enhanced Photodynamic/Photothermal Therapy

Biomaterials Science ◽

10.1039/d0bm01863e ◽

2021 ◽

Author(s):

Jia Chen ◽

Yunxiao Cui ◽

Kewei Song ◽

Tianqi Liu ◽

Luyao Zhou ◽

...

Keyword(s):

Photodynamic Therapy ◽

Synergistic Effect ◽

Self Assembly ◽

Photothermal Therapy ◽

Near Infrared ◽

Boron Dipyrromethene

Simultaneous near-infrared (NIR)-absorbed photodynamic therapy (PDT)/photothermal therapy (PTT) have been proved to be a promising approach to increase antitumor efficiency due to their synergistic effect. Herein, a boron dipyrromethene (BODIPY)-based...

Download Full-text

Inhibition of aggregation of meso-tetra(4-sulfonatophenyl)-porphyrin (H4TPPS) by urea

Journal of Porphyrins and Phthalocyanines ◽

10.1142/s1088424607000163 ◽

2007 ◽

Vol 11 (02) ◽

pp. 125-129 ◽

Cited By ~ 10

Author(s):

Mahmudur Rahman ◽

H. James Harmon

Keyword(s):

Hydrogen Bonding ◽

Fluorescence Lifetime ◽

Extinction Coefficient ◽

Intermolecular Hydrogen Bonding ◽

J Aggregates

The inhibition of the formation of J-aggregates of meso-tetra(4-sulfonatophenyl)-porphyrin ( H 4 TPPS ) by urea is investigated spectroscopically by absorbance, fluorescence, and fluorescence lifetime techniques. In 8 M urea at pH 2 with 0.1 M NaCl , diacid TPPS ( H 4 TPPS ) exists as a monomer up to 75 μM H 4 TPPS where the absorbance is linearly dependent on porphyrin concentration. The extinction coefficient of monomeric H 4 TPPS in 8 M urea at pH 2 with 0.1 M NaCl at 438 nm is 4.43 × 105 M -1. cm -1. No aggregation peaks at 491 nm and 708 nm are found in the 0.5-75 μM concentration range. Aggregated H 4 TPPS (10 μM) molecules in pH 2 buffer dissociate to monomers when the temperature is raised to 65°C. In D 2 O at pH 2, no aggregation is observed. These spectral observations suggest that the H 4 TPPS aggregation involves intermolecular hydrogen bonding.

Download Full-text