Coronary Plaque Burden and Adverse Plaque Characteristics Are Increased in Healthy Relatives of Patients With Early Onset Coronary Artery Disease

Introduction: Serum uric acid (sUA), a known inflammosome-inducer, is associated with prospective risk of coronary artery disease in a dose-dependent fashion. Psoriasis (PSO), a chronic inflammatory disease associated with elevated burden of systemic inflammation and subclinical coronary artery disease, provides a reliable human model to study how sUA may relate to non-calcified coronary plaque burden (NCB) measured by computed coronary tomography angiography (CCTA). Hypothesis: We hypothesized that sUA would directly associate with NCB beyond traditional cardiovascular (CV) risk factors. Methods: 103 consecutive PSO patients and 47 healthy volunteers (HV) underwent CCTA (320 detector row, Toshiba) for coronary plaque burden quantification using QAngio (Medis). PSO severity was assessed by Psoriasis Area Severity Score (PASI) and divided into severe PSO (PASI>10) and mild-moderate PSO (PASI<10). All patients had fasting blood draws for the measurement of sUA at a certified clinical lab. Results: PSO patients were older than HV and had a higher CV risk by Framingham risk score (FRS) (Table 1). We observed a significant trend towards increase in sUA among severe PSO, mild-moderate PSO, and HV groups (mean 6.4, 5.9, 5.4 respectively, p=0.02 for trend). A positive association was observed between sUA and NCB, which was stronger in severe PSO after adjustment for traditional CV risk, alcohol, statins, and systemic/biologic PSO treatment (Severe PSO: β=0.27, p<0.001; Mild-moderate PSO: β=0.18, p=0.03), not significant in HV (β=0.18, p=0.12). Conclusions: sUA is independently associated with NCB in states of chronic inflammation such as PSO, and as such, may potentially serve as a biomarker for subclinical coronary atherosclerosis. However, larger prospective studies of CV outcomes in chronic inflammatory diseases are needed to confirm these results.

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Coronary plaque burden in patients with stable and unstable coronary artery disease using multislice CT coronary angiography

La radiologia medica ◽

10.1007/s11547-011-0722-5 ◽

2011 ◽

Vol 116 (8) ◽

pp. 1174-1187 ◽

Cited By ~ 1

Author(s):

N. Mollet ◽

E. Maffei ◽

C. Martini ◽

A. Weustink ◽

C. van Mieghem ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Coronary Angiography ◽

Multislice Ct ◽

Coronary Plaque ◽

Ct Coronary Angiography ◽

Plaque Burden ◽

Unstable Coronary Artery Disease ◽

Artery Disease

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Characteristics of Coronary Artery Disease in Patients with Subclinical Hypothyroidism: Evaluation Using Coronary Artery Computed Tomography Angiography

10.21203/rs.3.rs-379839/v1 ◽

2021 ◽

Author(s):

Xin-zhu Zhou ◽

Rui Shi ◽

Jin Wang ◽

Ke Shi ◽

Xi Liu ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Subclinical Hypothyroidism ◽

Linear Regression Analysis ◽

Coronary Plaque ◽

Computed Tomographic Angiography ◽

Plaque Burden ◽

Computed Tomographic ◽

Luminal Narrowing ◽

Artery Disease

Abstract Background: Subclinical hypothyroidism (SCH) has recently been acknowledged as an independent risk factor for coronary artery disease (CAD). However, the characteristics of CAD in patients with SCH are not fully understood. This study aims to evaluate the features of CAD in patients with SCH using coronary computed tomographic angiography (CCTA).Materials and Methods: From 1 April, 2018 to 30 June, 2020, 234 consecutive SCH patients with coronary plaques identified on CCTA were included retrospectively. They were further subdivided into different degree of SCH groups (mild SCH vs. moderate SCH vs. severe SCH: 143 vs 62 vs 28) and different gender groups (men with SCH vs. women with SCH:116 vs 118). The distributions and types of plaques, luminal narrowing, segment involvement scores (SIS) and segment stenosis scores (SSS) were evaluated and compared among the different groups.Results: Patients with severe SCH had fewer calcified plaques (0.7 ± 0.9 vs. 2.0 ± 1.9, p < 0.001) and more non-calcified plaques (0.9 ± 1.0 vs. 0.3 ± 0.5, p < 0.001) than those with mild SCH. As the SCH condition worsened, the proportion of non-calcified plaques significantly increased. Whereas there were no significant discrepancies in SIS and SSS among patients with different grades of SCH (all p > 0.05). Men with SCH had higher SIS (3.9 ± 2.3 vs. 3.0 ± 2.3, p = 0.004) and SSS (7.8 ± 5.4 vs. 5.4 ± 3.0, p = 0.002) than women. Multivariate logistic and linear regression analysis demonstrated that grades of SCH (Moderate SCH, odds ratio [OR]: 2.11; 95% CI 1.03–4.34, p = 0.042; severe SCH, OR: 10.00; 95% CI 3.82–26.20, p < 0.001, taken mild SCH as a reference) was independently associated with the presence of non-calcified plaques, whereas sex (B: 1.67; 95% CI 0.27–3.10, p = 0.009) was independently associated with SSS. Conclusions: Severe SCH is associated with non-calcified plaques, and men with SCH have higher total plaque burden than women. We suggest that it is important to evaluate for coronary plaque in SCH patients, especially those with severe SCH and men with SCH.

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Coronary plaque tissue characterization in patients with premature coronary artery disease

The International Journal of Cardiovascular Imaging ◽

10.1007/s10554-020-01794-9 ◽

2020 ◽

Vol 36 (6) ◽

pp. 1003-1011

Author(s):

Jianchang Xie ◽

Jie Qi ◽

Hengyi Mao ◽

Ningfu Wang ◽

Xianhua Ye ◽

...

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Coronary Plaque ◽

Plaque Burden ◽

Premature Coronary Artery Disease ◽

Coronary Risk Factors ◽

Matching Procedure ◽

Premature Cad ◽

Artery Disease

Abstract Premature coronary artery disease (CAD) studies rarely involve coronary plaque characterization. We characterize coronary plaque tissue by radiofrequency intravascular ultrasound (IVUS) in patients with premature CAD. From July 2015 to December 2017, 220 patients from the Department of Cardiology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine with first occurrence of angina or myocardial infarction within 3 months were enrolled. Patients with premature CAD (n = 47, males aged < 55 years, and females aged < 65 years) or later CAD (n = 155) were retrospectively compared for cardiovascular risk factors, laboratory examination findings, coronary angiography data, gray-scale IVUS, and iMap-IVUS. The mean age was 53.53 ± 7.24 vs. 70.48 ± 8.74 years (p < 0.001). The groups were similar for traditional coronary risk factors except homocysteine (18.60 ± 5.15 vs. 17.08 ± 4.27 µmol/L, p = 0.043). After matching for baseline characteristics, LDL cholesterol (LDL-C) was higher for premature CAD than later CAD (2.50 ± 0.96 vs. 2.17 ± 0.80 mmol/L, p = 0.019). Before the matching procedure, the premature CAD group had shorter target lesion length [18.50 (12.60–32.00) vs. 27.90 (18.70–37.40) mm, p = 0.002], less plaque volume [175.59 (96.60–240.50) vs. 214.73 (139.74–330.00) mm3, p = 0.013] than the later CAD group. After the matching procedure, the premature CAD group appeared to be less plaque burden (72.69 ± 9.99 vs. 74.85 ± 9.80%, p = 0.005), and positive remodeling (1.03 ± 0.12 vs. 0.94 ± 0.18, p = 0.034), and lower high risk feature incidence (p = 0.006) than the later CAD group. At the plaque’s minimum lumen, premature CAD had more fibrotic (p < 0.001), less necrotic (p = 0.001) and less calcified areas (p = 0.012). Coronary plaque tissue was more fibrotic with less necrotic and calcified components in premature than in later CAD, and the range and degree of atherosclerosis were significantly lower.

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Association of Epicardial Adipose Tissue Volume and Total Coronary Plaque Burden in Patients with Coronary Artery Disease

International Heart Journal ◽

10.1536/ihj.17-709 ◽

2018 ◽

Vol 59 (6) ◽

pp. 1219-1226 ◽

Cited By ~ 7

Author(s):

Kennosuke Yamashita ◽

Myong Hwa Yamamoto ◽

Wataru Igawa ◽

Morio Ono ◽

Takehiko Kido ◽

...

Keyword(s):

Coronary Artery Disease ◽

Adipose Tissue ◽

Coronary Artery ◽

Epicardial Adipose Tissue ◽

Coronary Plaque ◽

Plaque Burden ◽

Tissue Volume ◽

Adipose Tissue Volume ◽

Artery Disease

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Relation of Plasma Lipoprotein(a) to Subclinical Coronary Plaque Volumes, Three-Vessel and Left Main Coronary Disease, and Severe Coronary Stenoses in Apparently Healthy African-Americans With a Family History of Early-Onset Coronary Artery Disease

The American Journal of Cardiology ◽

10.1016/j.amjcard.2016.06.020 ◽

2016 ◽

Vol 118 (5) ◽

pp. 656-661 ◽

Cited By ~ 8

Author(s):

Brian G. Kral ◽

Rita R. Kalyani ◽

Lisa R. Yanek ◽

Dhananjay Vaidya ◽

Elliot K. Fishman ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Family History ◽

Early Onset ◽

Coronary Plaque ◽

Left Main ◽

History Of ◽

Coronary Stenoses ◽

Artery Disease ◽

Apparently Healthy

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Risk factor profiling and study of atherosclerotic coronary plaque burden and morphology with coronary computed tomography angiography in coronary artery disease among young Indians

International Journal of Cardiology ◽

10.1016/j.ijcard.2017.04.090 ◽

2017 ◽

Vol 240 ◽

pp. 452-457 ◽

Cited By ~ 4

Author(s):

R. Chaudhary ◽

A. Chauhan ◽

M. Singhal ◽

S. Bagga

Keyword(s):

Computed Tomography ◽

Coronary Artery Disease ◽

Risk Factor ◽

Coronary Artery ◽

Computed Tomography Angiography ◽

Coronary Computed Tomography Angiography ◽

Coronary Plaque ◽

Plaque Burden ◽

Coronary Computed Tomography ◽

Artery Disease

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Noncalcified Coronary Plaque Volumes in Healthy People With a Family History of Early Onset Coronary Artery Disease

Circulation Cardiovascular Imaging ◽

10.1161/circimaging.113.000980 ◽

2014 ◽

Vol 7 (3) ◽

pp. 446-453 ◽

Cited By ~ 23

Author(s):

Brian G. Kral ◽

Lewis C. Becker ◽

Dhananjay Vaidya ◽

Lisa R. Yanek ◽

Rehan Qayyum ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Family History ◽

Early Onset ◽

Coronary Plaque ◽

Healthy People ◽

History Of ◽

Artery Disease

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Characteristics of coronary artery disease in patients with subclinical hypothyroidism: evaluation using coronary artery computed tomography angiography

BMC Cardiovascular Disorders ◽

10.1186/s12872-021-02116-0 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Xin-zhu Zhou ◽

Rui Shi ◽

Jin Wang ◽

Ke Shi ◽

Xi Liu ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Subclinical Hypothyroidism ◽

Linear Regression Analysis ◽

Coronary Plaque ◽

Computed Tomographic Angiography ◽

Plaque Burden ◽

Computed Tomographic ◽

Luminal Narrowing ◽

Artery Disease

Abstract Background Subclinical hypothyroidism (SCH) has recently been acknowledged as an independent risk factor for coronary artery disease (CAD). However, the characteristics of CAD in patients with SCH are not fully understood. This study aims to evaluate the features of CAD in patients with SCH using coronary computed tomographic angiography (CCTA). Materials and methods From 1 April, 2018 to 30 June, 2020, 234 consecutive SCH patients with coronary plaques identified on CCTA were included retrospectively. They were further subdivided into different degree of SCH groups (mild SCH vs. moderate SCH vs. severe SCH: 143 vs 62 vs 28) and different gender groups (men with SCH vs. women with SCH:116 vs 118). The distributions and types of plaques, luminal narrowing, segment involvement scores (SIS) and segment stenosis scores (SSS) were evaluated and compared among the different groups. Results Patients with severe SCH had fewer calcified plaques (0.7 ± 0.9 vs. 2.0 ± 1.9, p < 0.001) and more non-calcified plaques (0.9 ± 1.0 vs. 0.3 ± 0.5, p < 0.001) than those with mild SCH. As the SCH condition worsened, the proportion of non-calcified plaques significantly increased. Whereas there were no significant discrepancies in SIS and SSS among patients with different grades of SCH (all p > 0.05). Men with SCH had higher SIS (3.9 ± 2.3 vs. 3.0 ± 2.3, p = 0.004) and SSS (7.8 ± 5.4 vs. 5.4 ± 3.0, p = 0.002) than women. Multivariate logistic and linear regression analysis demonstrated that grades of SCH (Moderate SCH, odds ratio [OR] 2.11; 95% CI 1.03–4.34, p = 0.042; severe SCH, OR: 10.00; 95% CI 3.82–26.20, p < 0.001, taken mild SCH as a reference) was independently associated with the presence of non-calcified plaques, whereas sex (B: 1.67; 95% CI 0.27–3.10, p = 0.009) was independently associated with SSS. Conclusions Severe SCH is associated with non-calcified plaques, and men with SCH have higher total plaque burden than women. We suggest that it is important to evaluate for coronary plaque in SCH patients, especially those with severe SCH and men with SCH.

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