Ultrasound-mediated targeted drug delivery with a novel cyclodextrin-based drug carrier by mechanical and thermal mechanisms

Emergence of various nanoscale drug carrier platforms as Drug Delivery Systems (DDS) has revolutionized the field of medicine.Nonetheless, theside-effects due to non-specific distribution of anticancer therapeutics in normal, healthy tissues remain to be a prime pitfall in curing cancers. Therefore, to achieve a better therapeutic efficacy, the use of a target-specific delivery, combined with a stimuli-responsive nanocarrier system, particularly pH-sensitive nanosystems offer an attractive strategy. Targeted drug delivery through pH-sensitive nanosystems offer the potential to enhance the therapeutic index of anticancer agents, either by increasing the drug concentration in tumor cells and/or by decreasing the exposure in normal host tissues. Therefore, nanoscale-based drug delivery through pH-sensitive nanosystems seem to be a boon for treating gynaecological cancers (as well as other cancers) without side-effects or with least harm to normal healthy tissues.

Download Full-text

In Vivo Studies of the Drug Carrying Magnetic Nanocomposite Spheres via Fluorescent Molecules

Volume 2: Biomedical and Biotechnology Engineering ◽

10.1115/imece2010-40266 ◽

2010 ◽

Author(s):

H. E. Misak ◽

R. Asmatulu ◽

J. S. Gopu ◽

S. Zheng ◽

P. Wooley ◽

...

Keyword(s):

Drug Delivery ◽

Targeted Drug Delivery ◽

Drug Carrier ◽

Fluorescent Microscopy ◽

In Vivo Studies ◽

Fluorescent Nanoparticles ◽

In Vivo Test ◽

Straightforward Method ◽

Targeted Drug

Nanospheres utilized in targeted drug delivery systems have seen much attention, however it is difficult to detect the nanospheres in an in-vivo test due to their nanoscale in size. This is a crucial step in targeted drug delivery to show the nanosphere being concentrated at the spot of interest. Nanospheres developed by oil in oil (o/o) emulsion technique have the advantage of encapsulating molecules, such as 1,6-Diphenyl-1,3,5-hexatriene (DPH), without damages and chemical alterations. In current study, DPH was encapsulated into a nanosphere as a fluorescing tracer to visualize the nanospheres trafficking in a mouse model of squamous cell carcinoma (SCC). The SCC tumors were established on nude mice. 0.5 ml of a 0.3 mg/ml solution of fluorcescent nanospheres were subcutaneously injected around the tumor. The injections of the drug carrier system were repeated at 2-day intervals till the sacrifice of the tumor-bearing animals on day 10. The tumors were retrieved for frozen and paraffin-embedded histological preparation. Fluorsescent microscopy was used to image the frozen sections, and compared with H&E stained sections. The fluorescence nanoparticles were easily identifiable under fluorescent microscopy, while typical histology images were unable to detect the nanospheres. The data suggest that fluorescent nanoparticles can be used to identify the location or localization of the nanospheres in an in-vivo environment in a simple and straightforward method that aids in characterization of targeted drug delivery.

Download Full-text

Preparation and Characterization of Fe3O4 Magnetic Nanoparticles Labeled with Technetium-99m Pertectnetate

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.459.51 ◽

2013 ◽

Vol 459 ◽

pp. 51-59 ◽

Cited By ~ 1

Author(s):

Chang Shu Tsai ◽

Wei Chung Liu ◽

Hong Yi Chen ◽

Wei Chun Hsu

Keyword(s):

Drug Delivery ◽

Magnetic Nanoparticles ◽

Targeted Drug Delivery ◽

Magnetic Nanoparticle ◽

Drug Carrier ◽

Precipitation Method ◽

Technetium 99M ◽

Reducing Ability ◽

Targeted Drug

In the aspect of biomedical diagnosis, magnetic nanoparticle can be used as drug carrier and MRI/ SPECT/ PET contrast agents. Magnetic fluid hyperthermia is one of the most important cancer therapies. Magnetic nanoparticles display their unique features as heating mediators for hyperthermia. In this study, Fe3O4magnetic nanoparticle was prepared by using chemical co-precipitation method. Tc-99m pertechnetate with Fe3O4magnetic nanoparticles is prepared by using magnet adsorption method. An attempt was also made to evaluate the application in the field of magnetic targeted drug delivery and radioactive targeted cancer treatment in the future. In this work, preparation and characterization of non-polymer and polymer (dextran) coated Fe3O4magnetic nanoparticles labeled with technetium-99m pertectnetate were evaluated and served as precursors study. The Tc-99m labeling efficiency of in-house Fe3O4magnetic nanoparticles (MNP) and commercial kit were ca.98.4 % and 85% (n=5), under the same conc. of 6mM, 0.1 ml of SnCl2·2H2O, respectively. The Tc-99m labeling efficiency of magnetic nanoparticles with its dextran-coated was ca. 58.2% (n=5) at the same conc. and volume of SnCl2·2H2O. The in-vitro stabilities of the 3 kinds of magnetite magnetic fluids were higher than 96.0% (n=5) during 2 hours. The reducing agent of SnCl2·2H2O plays a key role due to its reducing ability for Tc-99m pertechnetate. The optimal reaction time of SnCl2·2H2O with Tc-99m is better under 1 hour. In conclusion, the Fe3O4magnetic nanoparticle labeled with Tc-99m pertechnetate has shown good qualities for its labeling efficiency and stability. It may be feasible preliminary to utilize in the application of magnetic targeted drug delivery of bio-medicine.

Download Full-text

Construction of long-circulation EpCAM targeted drug delivery system and its application in the diagnosis and treatment of breast cancer

Journal of Biomaterials Applications ◽

10.1177/0885328220965135 ◽

2020 ◽

pp. 088532822096513

Author(s):

Chao Song ◽

Chao Gao ◽

Jing Zhao ◽

Zhenxin Wang

Keyword(s):

Breast Cancer ◽

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Targeted Drug Delivery ◽

Drug Carrier ◽

Average Particle Size ◽

Average Particle ◽

Tumor Focus ◽

Targeted Drug

Docetaxel (DOX) is usually one of drugs used for breast cancer treatment. The key of targeted drug delivery therapy is to deliver effective drugs directly and safely to the tumor focus via an efficient targeting drug carrier with immunogenicity. In this study, Long-circulating targeted drug carrying microspheres (DOX-PEG-EpCAM-MNs) entrapping DOX were constructed. In addition, both cytotoxicity and magnetic resonance imaging (MRI) analyses were performed to establish a mouse model and further complete corresponding performance analysis.The results showed that the average particle size of DOX-PEG-EpCAM-MNs was 139.3 ± 1.6 nm. Morphological analysis proves that they are spherical and uniformly dispersed. The Corresponding entrapment rate and drug carrying capacity are 82.43% and 7.16% respectively. Additionally, MRI shows that they have the capability to track tumor cells within 5 days. This study established a safe and efficient breast cancer cells targeted long-circulating drug delivery system.

Download Full-text

Aptamer-anchored di-polymer shell-capped mesoporous carbon as a drug carrier for bi-trigger targeted drug delivery

Journal of Materials Chemistry B ◽

10.1039/c7tb01528c ◽

2017 ◽

Vol 5 (33) ◽

pp. 6882-6889 ◽

Cited By ~ 14

Author(s):

Yang Zhang ◽

Yan-Qin Chang ◽

Lu Han ◽

Yue Zhang ◽

Ming-Li Chen ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Targeted Drug Delivery ◽

Mesoporous Carbon ◽

Carbon Nanomaterials ◽

Drug Carrier ◽

Polymer Shell ◽

Targeted Drug

Mesoporous carbon nanomaterials have found applications in drug delivery and cancer therapy.

Download Full-text

TARGETED DRUG DELIVERY SYSTEM; NANOPARTICLE BASED COMBINATION OF CHITOSAN AND ALGINATE FOR CANCER THERAPY: A REVIEW

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2021.v13s4.43818 ◽

2021 ◽

pp. 69-76

Author(s):

ADE IRMA SURYANI ◽

NASRUL WATHONI ◽

MUCHTARIDI MUCHTARIDI ◽

I. MADE JONI

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Targeted Drug Delivery ◽

English Language ◽

High Efficiency ◽

Drug Carrier ◽

Target Cells ◽

Drug Induced ◽

Release Process ◽

Targeted Drug

This review aimed to determine the potential of the combination of chitosan and alginate as a targeted drug carrier in cancer therapy. This article is based on the results of previous research journals collected from Google Scholar, Scopus, PubMed and Science Direct sites using the keywords chitosan, alginate, targeted drug delivery for cancer, nanoparticle chitosan alginate. With the inclusion criteria, only English-language journals, journals published in the last 10 y, related to chitosan and alginate-based formulations. Meanwhile, the exclusion criteria were journals on pharmacological properties and bioactivity, food and cosmetics. The combination of cationic chitosan and anionic alginate forming strong cross-links showed good mucoadhesive properties, higher resistance to low pH and high-efficiency encapsulation without showing any obvious cytotoxicity. Ch/Alg can overcome the shortcomings of the active substance, such as its rapid release process and the required active ingredient is lower than that required to enter the cancer target cells so as to minimize side effects of the drug by providing drug-induced release. in response to various stimuli that are well suited to the intended purpose, such as pH stimuli, redox gradients, light, temperature, and magnetism. It is shown that the combination of chitosan and alginate base has great potential in targeting cancer therapy by increasing its therapeutic effectiveness and selectivity.

Download Full-text

Chitosan overlaid Fe3O4/rGO nanocomposite for targeted drug delivery, imaging, and biomedical applications

Scientific Reports ◽

10.1038/s41598-020-76015-3 ◽

2020 ◽

Vol 10 (1) ◽

Cited By ~ 1

Author(s):

Viswanathan Karthika ◽

Mohamad S. AlSalhi ◽

Sandhanasamy Devanesan ◽

Kasi Gopinath ◽

Ayyakannu Arumugam ◽

...

Keyword(s):

Drug Delivery ◽

Folic Acid ◽

Targeted Drug Delivery ◽

Drug Carrier ◽

Drug Loading ◽

Antioxidant Properties ◽

Targeted Drug ◽

Loading Amount

Abstract A hybrid and straightforward nanosystem that can be used simultaneously for cancer-targeted fluorescence imaging and targeted drug delivery in vitro was reported in this study. A chitosan (CS) polymer coated with reduced graphene oxide (rGO) and implanted with Fe3O4 nanoparticles was fabricated. The fundamental physicochemical properties were confirmed via FT-IR, XRD, FE-SEM, HR-TEM, XPS, and VSM analysis. The in vivo toxicity study in zebrafish showed that the nanocomposite was not toxic. The in vitro drug loading amount was 0.448 mg/mL−1 for doxorubicin, an anticancer therapeutic, in the rGO/Fe3O4/CS nanocomposite. Furthermore, the pH-regulated release was observed using folic acid. Cellular uptake and multimodal imaging revealed the benefit of the folic acid-conjugated nanocomposite as a drug carrier, which remarkably improves the doxorubicin accumulation inside the cancer cells over-express folate receptors. The rGO/Fe3O4/CS nanocomposite showed enhanced antibiofilm and antioxidant properties compared to other materials. This study's outcomes support the use of the nanocomposite in targeted chemotherapy and the potential applications in the polymer, cosmetic, biomedical, and food industries.

Download Full-text