TARGETED DRUG DELIVERY SYSTEM; NANOPARTICLE BASED COMBINATION OF CHITOSAN AND ALGINATE FOR CANCER THERAPY: A REVIEW

This review aimed to determine the potential of the combination of chitosan and alginate as a targeted drug carrier in cancer therapy. This article is based on the results of previous research journals collected from Google Scholar, Scopus, PubMed and Science Direct sites using the keywords chitosan, alginate, targeted drug delivery for cancer, nanoparticle chitosan alginate. With the inclusion criteria, only English-language journals, journals published in the last 10 y, related to chitosan and alginate-based formulations. Meanwhile, the exclusion criteria were journals on pharmacological properties and bioactivity, food and cosmetics. The combination of cationic chitosan and anionic alginate forming strong cross-links showed good mucoadhesive properties, higher resistance to low pH and high-efficiency encapsulation without showing any obvious cytotoxicity. Ch/Alg can overcome the shortcomings of the active substance, such as its rapid release process and the required active ingredient is lower than that required to enter the cancer target cells so as to minimize side effects of the drug by providing drug-induced release. in response to various stimuli that are well suited to the intended purpose, such as pH stimuli, redox gradients, light, temperature, and magnetism. It is shown that the combination of chitosan and alginate base has great potential in targeting cancer therapy by increasing its therapeutic effectiveness and selectivity.

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Aptamer-anchored di-polymer shell-capped mesoporous carbon as a drug carrier for bi-trigger targeted drug delivery

Journal of Materials Chemistry B ◽

10.1039/c7tb01528c ◽

2017 ◽

Vol 5 (33) ◽

pp. 6882-6889 ◽

Cited By ~ 14

Author(s):

Yang Zhang ◽

Yan-Qin Chang ◽

Lu Han ◽

Yue Zhang ◽

Ming-Li Chen ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Targeted Drug Delivery ◽

Mesoporous Carbon ◽

Carbon Nanomaterials ◽

Drug Carrier ◽

Polymer Shell ◽

Targeted Drug

Mesoporous carbon nanomaterials have found applications in drug delivery and cancer therapy.

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Lipid-based Nanoplatforms in Cancer Therapy: Recent Advances and Applications

Current Cancer Drug Targets ◽

10.2174/1568009620666200115160805 ◽

2020 ◽

Vol 20 (4) ◽

pp. 271-287 ◽

Cited By ~ 2

Author(s):

Kuldeep Rajpoot

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Adverse Effects ◽

Targeted Drug Delivery ◽

Tumor Therapy ◽

Cancer Therapies ◽

Medication Delivery ◽

Lipid Nanocarriers ◽

Targeted Drug ◽

Drug Nanocarriers

Though modern available cancer therapies are effective, they possess major adverse effects, causing non-compliance to patients. Furthermore, the majority of the polymeric-based medication platforms are certainly not universally acceptable, due to their several restrictions. With this juxtaposition, lipid-based medication delivery systems have appeared as promising drug nanocarriers to replace the majority of the polymer-based products because they are in a position to reverse polymer as well as, drug-associated restrictions. Furthermore, the amalgamation of the basic principle of nanotechnology in designing lipid nanocarriers, which are the latest form of lipid carriers, has tremendous chemotherapeutic possibilities as tumor-targeted drug-delivery pertaining to tumor therapy. Apart from this, it is reported that nearly 40% of the modern medication entities are lipophilic. Moreover, research continues to be efficient in attaining a significant understanding of the absorption and bioavailability of the developed lipids systems.

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Structural requirement of G-quadruplex/aptamer-combined DNA macromolecule serving as efficient drug carrier for cancer-targeted drug delivery

European Journal of Pharmaceutics and Biopharmaceutics ◽

10.1016/j.ejpb.2020.11.021 ◽

2020 ◽

Author(s):

Congcong Li ◽

Biting Wu ◽

Si Chen ◽

Kaixuan Hao ◽

Jie Yang ◽

...

Keyword(s):

Drug Delivery ◽

Targeted Drug Delivery ◽

Drug Carrier ◽

Structural Requirement ◽

G Quadruplex ◽

Targeted Drug

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Protein Nanocarriers for Targeted Drug Delivery for Cancer Therapy

Nanocarriers for Drug Delivery ◽

10.1016/b978-0-12-814033-8.00006-0 ◽

2019 ◽

pp. 173-204 ◽

Cited By ~ 3

Author(s):

Mahadevappa Y. Kariduraganavar ◽

Geetha B. Heggannavar ◽

Sandra Amado ◽

Geoffrey R. Mitchell

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Targeted Drug Delivery ◽

Targeted Drug

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Biophysical characterization of DNA origami nanostructures reveals inaccessibility to intercalation binding sites

10.1101/845420 ◽

2019 ◽

Author(s):

Helen L. Miller ◽

Sonia Contera ◽

Adam J.M. Wollman ◽

Adam Hirst ◽

Katherine E. Dunn ◽

...

Keyword(s):

Drug Delivery ◽

Single Molecule ◽

Targeted Drug Delivery ◽

Binding Sites ◽

Dna Origami ◽

Target Cells ◽

Dna Nanostructures ◽

Synthetic Dna ◽

Drug Molecules ◽

Targeted Drug

AbstractIntercalation of drug molecules into synthetic DNA nanostructures formed through self-assembled origami has been postulated as a valuable future method for targeted drug delivery. This is due to the excellent biocompatibility of synthetic DNA nanostructures, and high potential for flexible programmability including facile drug release into or near to target cells. Such favourable properties may enable high initial loading and efficient release for a predictable number of drug molecules per nanostructure carrier, important for efficient delivery of safe and effective drug doses to minimise non-specific release away from target cells. However, basic questions remain as to how intercalation-mediated loading depends on the DNA carrier structure. Here we use the interaction of dyes YOYO-1 and acridine orange with a tightly-packed 2D DNA origami tile as a simple model system to investigate intercalation-mediated loading. We employed multiple biophysical techniques including single-molecule fluorescence microscopy, atomic force microscopy, gel electrophoresis and controllable damage using low temperature plasma on synthetic DNA origami samples. Our results indicate that not all potential DNA binding sites are accessible for dye intercalation, which has implications for future DNA nanostructures designed for targeted drug delivery.

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Targeted drug delivery for cancer therapy

Biomaterials for Cancer Therapeutics ◽

10.1533/9780857096760.1.31 ◽

2013 ◽

pp. 31-56 ◽

Cited By ~ 2

Author(s):

D.L. Stirland ◽

J.W. Nichols ◽

T.A. Denison ◽

Y.H. Bae

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Targeted Drug Delivery ◽

Targeted Drug

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ROS-Responsive Chitosan Coated Magnetic Iron Oxide Nanoparticles as Potential Vehicles for Targeted Drug Delivery in Cancer Therapy

International Journal of Nanomedicine ◽

10.2147/ijn.s249240 ◽

2020 ◽

Vol Volume 15 ◽

pp. 3333-3346 ◽

Cited By ~ 2

Author(s):

Srinivasan Ayyanaar ◽

Chandrasekar Balachandran ◽

Rangaswamy Chinnabba Bhaskar ◽

Mookkandi Palsamy Kesavan ◽

Shin Aoki ◽

...

Keyword(s):

Drug Delivery ◽

Iron Oxide ◽

Cancer Therapy ◽

Iron Oxide Nanoparticles ◽

Targeted Drug Delivery ◽

Oxide Nanoparticles ◽

Magnetic Iron Oxide Nanoparticles ◽

Magnetic Iron Oxide ◽

Targeted Drug

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Green-emitting carbon dot loaded silica nanoparticles coated with DNA-cross-linked hydrogels for sensitive carcinoembryonic antigen detection and effective targeted cancer therapy

Chemical Communications ◽

10.1039/c9cc07831b ◽

2019 ◽

Vol 55 (100) ◽

pp. 15101-15104 ◽

Cited By ~ 4

Author(s):

Xiaoting Ji ◽

Haoyuan Lv ◽

Xinxin Sun ◽

Caifeng Ding

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Carcinoembryonic Antigen ◽

Silica Nanoparticles ◽

Targeted Drug Delivery ◽

Antigen Detection ◽

Targeted Cancer Therapy ◽

Carbon Dot ◽

Targeted Drug

Bifunctional composite nanospheres for carcinoembryonic antigen sensing and targeted drug delivery, based on carbon dot loaded silica nanoparticles coated with DNA-cross-linked hydrogels.

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Recent advances in combinatorial cancer therapy via multifunctionalized gold nanoparticles

Nanomedicine ◽

10.2217/nnm-2020-0051 ◽

2020 ◽

Vol 15 (12) ◽

pp. 1221-1237

Author(s):

Touqeer Ahmad ◽

Rizwana Sarwar ◽

Ayesha Iqbal ◽

Uzma Bashir ◽

Umar Farooq ◽

...

Keyword(s):

Drug Delivery ◽

Gold Nanoparticles ◽

Cancer Therapy ◽

Targeted Drug Delivery ◽

Photothermal Therapy ◽

Therapeutic Implications ◽

Therapeutic Applications ◽

Diagnosis Of Cancer ◽

Targeted Drug ◽

Cancerous Cells

The diverse behavior of nanogold in the therapeutic field is related to its unique size and shape. Nanogold offers improvements in modern diagnostic and therapeutic implications, increases disease specificity and targeted drug delivery, and is relatively economical compared with other chemotherapeutic protocols. The diagnosis of cancer and photothermal therapy improve drastically with the implementation of nanotechnology. Different types of nanoparticles, that is, gold silica nanoshells, nanorods and nanospheres of diverse shapes and geometries, are used widely in the photothermal therapy of cancerous cells and nodules. Numerous reviews have been published on the therapeutic applications of gold nanoparticles, but studies on combinatorial applications of nanogold in cancer therapy are limited. This review focuses on the combinatorial cancer therapy using optical properties of nanogold with different shapes and geometries, and their therapeutic applications in cancer diagnosis, photothermal therapy, cancer imaging and targeted drug delivery.

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