Dextran-platinum(IV) conjugate as drug carrier for triggered drug release

2015 ◽  
Vol 213 ◽  
pp. e96 ◽  
Author(s):  
Shasha He ◽  
Dongfang Zhou ◽  
Huihui Kuang ◽  
Yanjuan Wu ◽  
Xiabin Jing ◽  
...  
Keyword(s):  
Drug Release ◽  
Drug Carrier ◽  
Triggered Drug Release

A Novel Chitosan Microbubble as Ultrasound-Triggered Drug Carrier for Antitumor In Vitro

2014 ◽  
Vol 636 ◽  
pp. 139-143
Author(s):  
Song Shen ◽  
Bei Ding ◽  
Qing Li ◽  
Xu Wei Yu ◽  
Xue Yong Qi ◽  
...  
Keyword(s):  
Drug Release ◽  
Drug Carrier ◽  
Tumor Therapy ◽  
Carboxymethyl Chitosan ◽  
Ultrasound Contrast Agents ◽  
Ultrasound Contrast ◽  
Triggered Drug Release ◽  
Ultrasound Assisted ◽  
Potential Strategy

Uniform Microbubbles (MBs) were routinely used as ultrasound contrast agents, but the MBs served for drug carrier showed well-marked advantage. In this study, we prepared a novel docetaxel–loaded microbubbles by carboxymethyl chitosan with W/O/W emulsion technique. Then, the surface morphology was characterized by scanning electron microscope (SEM). Ultrasound-triggered drug release experiments were performed with adjustable intensity and time. In the antitumor experiment in vitro, Ultrasound-assisted drug release from MBs exhibited good treatment of tumor. The results proved the combination of ultrasound and drug-loaded carboxymethyl chitosan microbubbles could be used as a potential strategy for anti-tumor therapy.

scholarly journals pH-Sensitive N-doped carbon dots–heparin and doxorubicin drug delivery system: preparation and anticancer research

RSC Advances ◽  
2017 ◽  
Vol 7 (15) ◽  
pp. 9347-9356 ◽  
Author(s):  
Ming Zhang ◽  
Ping Yuan ◽  
Ninglin Zhou ◽  
Yutian Su ◽  
Maoni Shao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carbon Dots ◽  
Drug Carrier ◽  
Ph Sensitive ◽  
Triggered Drug Release ◽  
Model Drug ◽  
Doped Carbon Dots

In this study, doxorubicin (DOX) hydrochloride as a model drug, N-doped carbon dots as a drug carrier, and heparin as an auxiliary medicine were selected to design and prepare a multi-functional drug delivery system with pH-triggered drug release.

scholarly journals Covalently Functionalized Carbon Nano-Onions Integrated Gelatin Methacryloyl Nanocomposite Hydrogel Containing γ-Cyclodextrin as Drug Carrier for High-Performance pH-Triggered Drug Release

2021 ◽  
Vol 14 (4) ◽  
pp. 291
Author(s):  
Narsimha Mamidi ◽  
Ramiro Manuel Velasco Delgadillo ◽  
Enrique V. Barrera
Keyword(s):  
Drug Release ◽  
High Performance ◽  
Drug Carrier ◽  
Controlled Delivery ◽  
Supramolecular Hydrogel ◽  
Swelling Properties ◽  
Human Fibroblast Cells ◽  
Future Drug ◽  
Acidic Conditions ◽  
Triggered Drug Release

Herein, poly (n-(4-aminophenyl) methacrylamide)) carbon nano-onions (PAPMA-CNOs = f-CNOs) and γ-cyclodextrin/DOX-complex (CD) reinforced gelatin methacryloyl (GelMA)/f-CNOs/CD supramolecular hydrogel interfaces were fabricated using the photo-crosslinking technique. The physicochemical properties, morphology, biodegradation, and swelling properties of hydrogels were investigated. The composite hydrogels demonstrated enriched drug release under the acidic conditions (pH 4.5 = 99%, and pH 6.0 = 82%) over 18 days. Owing to the f-CNOs inclusion, GelMA/f-CNOs/CD supramolecular hydrogels presented augmented tensile strength (σult = 356.1 ± 3.4 MPa), toughness (K = 51.5 ± 0.24 Jg−1), and Young’s modulus (E = 41.8 ± 1.4 GPa). The strengthening of GelMA/f-CNOs/CD hydrogel systems indicates its good dispersion and the degree of polymer enveloping of f-CNOs within GelMA matrixes. Furthermore, the obtained hydrogels showed improved cell viability with human fibroblast cells. Nevertheless, the primed supramolecular hydrogels would pave the way for the controlled delivery systems for future drug delivery.

Designed Spider Silk-Based Drug Carrier for Redox- or pH-Triggered Drug Release

2020 ◽  
Vol 21 (12) ◽  
pp. 4904-4912
Author(s):  
Heike M. Herold ◽  
Annika Döbl ◽  
Stefanie Wohlrab ◽  
Martin Humenik ◽  
Thomas Scheibel
Keyword(s):  
Drug Release ◽  
Spider Silk ◽  
Drug Carrier ◽  
Triggered Drug Release

scholarly journals Folic acid and deoxycholic acid derivative modified Fe3O4 nanoparticles for efficient pH-dependent drug release and multi-targeting against liver cancer cells

RSC Advances ◽  
2021 ◽  
Vol 11 (63) ◽  
pp. 39804-39812
Author(s):  
Xiaoyu Wang ◽  
Qing Ma ◽  
Chaochao Wen ◽  
Tao Gong ◽  
Jing Li ◽  
...  
Keyword(s):  
Folic Acid ◽  
Magnetic Nanoparticles ◽  
Liver Cancer ◽  
Drug Release ◽  
Deoxycholic Acid ◽  
Drug Carrier ◽  
Liver Cancer Cells ◽  
Triggered Drug Release ◽  
Ph Dependent ◽  
Tumor Cell Killing

A nano-drug carrier, FDCA-FA-MNPs was constructed by modifying Fe3O4 magnetic nanoparticles (MNPs) with formyl deoxycholic acid (FDCA) and folic acid (FA) with double-targeting, pH-triggered drug release and excellent tumor cell killing efficiency.

Facile synthesis of organosilica-capped mesoporous silica nanocarriers with selective redox-triggered drug release properties for safe tumor chemotherapy

2019 ◽  
Vol 7 (5) ◽  
pp. 1825-1832 ◽  
Author(s):  
Luying Shen ◽  
Shan Pan ◽  
Dechao Niu ◽  
Jianping He ◽  
Xiaobo Jia ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Facile Synthesis ◽  
Triggered Drug Release ◽  
Facile Route

We develop a facile route to synthesize organosilica-capped mesoporous silica nanocarriers for efficient and safe redox-triggered tumor chemotherapy.

scholarly journals pH-triggered degradation and release of doxorubicin from zeolitic imidazolate framework-8 (ZIF8) decorated with polyacrylic acid

RSC Advances ◽  
2021 ◽  
Vol 11 (16) ◽  
pp. 9222-9234
Author(s):  
Vy Anh Tran ◽  
Sang-Wha Lee
Keyword(s):  
Drug Release ◽  
Polyacrylic Acid ◽  
Acidic Ph ◽  
Zeolitic Imidazolate Framework ◽  
Triggered Drug Release

The ZIF8–Dox@PAA nanocarrier demonstrated pH-triggered drug release through the detachment of the PAA layer along with the destruction of ZIF8 framework in acidic pH environment.

PEG–PEI-modified gated N-doped mesoporous carbon nanospheres for pH/NIR light-triggered drug release and cancer phototherapy

2021 ◽  
Author(s):  
Snigdharani Panda ◽  
Chandra Sekhar Bhol ◽  
Sujit Kumar Bhutia ◽  
Sasmita Mohapatra
Keyword(s):  
Drug Release ◽  
Mesoporous Carbon ◽  
Laser Excitation ◽  
Outer Shell ◽  
Carbon Nanospheres ◽  
Nir Light ◽  
Triggered Drug Release ◽  
Hybrid Nanoparticle

A hybrid nanoparticle consisting of N-doped mesoporous carbon nanospheres as core and thermosensitive PEG–PEI as outer shell shows multiple therapeutic actions such as PTT, PDT and NIR sensitive drug release under single 980 nm laser excitation.

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