Folic acid and deoxycholic acid derivative modified Fe3O4 nanoparticles for efficient pH-dependent drug release and multi-targeting against liver cancer cells

A nano-drug carrier, FDCA-FA-MNPs was constructed by modifying Fe3O4 magnetic nanoparticles (MNPs) with formyl deoxycholic acid (FDCA) and folic acid (FA) with double-targeting, pH-triggered drug release and excellent tumor cell killing efficiency.

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Folic Acid-Conjugated pH and Redox-Sensitive Ellipsoidal Hybrid Magnetic Nanoparticles for Dual-Triggered Drug Release

ACS Applied Bio Materials ◽

10.1021/acsabm.0c00488 ◽

2020 ◽

Vol 3 (8) ◽

pp. 4949-4961

Author(s):

Gokcen Birlik Demirel ◽

Ebru Aygul ◽

Aydan Dag ◽

Sezen Atasoy ◽

Zeynep Cimen ◽

...

Keyword(s):

Folic Acid ◽

Magnetic Nanoparticles ◽

Drug Release ◽

Triggered Drug Release

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Targeted doxorubicin delivery to liver cancer cells by PEGylated mesoporous silica nanoparticles with a pH-dependent release profile

Microporous and Mesoporous Materials ◽

10.1016/j.micromeso.2012.05.035 ◽

2012 ◽

Vol 161 ◽

pp. 160-167 ◽

Cited By ~ 44

Author(s):

Jinlou Gu ◽

Shasha Su ◽

Mingjie Zhu ◽

Yongsheng Li ◽

Wenru Zhao ◽

...

Keyword(s):

Liver Cancer ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Cancer Cells ◽

Mesoporous Silica Nanoparticles ◽

Release Profile ◽

Liver Cancer Cells ◽

Ph Dependent ◽

Doxorubicin Delivery

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Hollow superparamagnetic iron oxide nanoshells as a hydrophobic anticancer drug carrier: intracelluar pH-dependent drug release and enhanced cytotoxicity

Nanoscale ◽

10.1039/c2nr30960b ◽

2012 ◽

Vol 4 (18) ◽

pp. 5744 ◽

Cited By ~ 43

Author(s):

Xiao-Ming Zhu ◽

Jing Yuan ◽

Ken Cham-Fai Leung ◽

Siu-Fung Lee ◽

Kathy W. Y. Sham ◽

...

Keyword(s):

Iron Oxide ◽

Drug Release ◽

Anticancer Drug ◽

Drug Carrier ◽

Superparamagnetic Iron Oxide ◽

Ph Dependent

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Application of Abdominal Imaging Based on Nano Drug Delivery System for Diagnosis and Treatment of Liver Cancer

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2021.18672 ◽

2021 ◽

Vol 21 (2) ◽

pp. 824-832

Author(s):

Zhenzhen Fan ◽

Qingsheng Liu ◽

Fangfang Lu ◽

Zhihui Dong ◽

Peng Gao

Keyword(s):

Drug Delivery ◽

Folic Acid ◽

Liver Cancer ◽

Drug Delivery System ◽

Delivery System ◽

Mesoporous Silica Nanoparticles ◽

Drug Carrier ◽

Diagnosis And Treatment ◽

Fluorescent Nanoparticles ◽

Abdominal Image

Liver cancer has a high incidence and a poor prognosis, which seriously affects human health. Doxorubicin is one of the chemotherapeutics used in the treatment of tumours, but its severe adverse reactions, especially cardiac toxicity, have limited its clinical application. The nanometre drug delivery system enables drug-loaded nanoparticles to be specifically concentrated in tumour tissues, increasing cell uptake and improving curative effect. Therefore, in this paper, folic acid-modified mesoporous silica nanoparticles (MSN-NH2-PEG-FA) were synthesized by modifying the folic acid on the surface of a drug carrier by using the characteristics of the expression of folic acid receptors, and using it as a drug. The carrier was loaded with antitumor drug doxorubicin hydrochloride (DOX), and a nanometre drug delivery system (MSN-NH2-PEG-FA/DOX) was constructed. At the same time, the near-infrared dye Cy5 was used to mark the mother nucleus to construct fluorescent nanoparticles (MSN-NH2-PEG-FA/DOX-Cy5) for cell and tumour imaging, so as to obtain the abdominal image of liver cancer patients, thereby realizing diagnosis and treatment. The research results show that the carrier can specifically gather in the liver area, reduce the distribution in the heart, reduce the toxic and side effects of drugs, and prolong the survival time of patients. The results of this study provide new ideas for the treatment of liver cancer, and provide a new theoretical basis and experimental basis for the study of inorganic nanomaterials as targeted drug delivery systems.

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A Novel Chitosan Microbubble as Ultrasound-Triggered Drug Carrier for Antitumor In Vitro

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.636.139 ◽

2014 ◽

Vol 636 ◽

pp. 139-143

Author(s):

Song Shen ◽

Bei Ding ◽

Qing Li ◽

Xu Wei Yu ◽

Xue Yong Qi ◽

...

Keyword(s):

Drug Release ◽

Drug Carrier ◽

Tumor Therapy ◽

Carboxymethyl Chitosan ◽

Ultrasound Contrast Agents ◽

Ultrasound Contrast ◽

Triggered Drug Release ◽

Ultrasound Assisted ◽

Potential Strategy

Uniform Microbubbles (MBs) were routinely used as ultrasound contrast agents, but the MBs served for drug carrier showed well-marked advantage. In this study, we prepared a novel docetaxel–loaded microbubbles by carboxymethyl chitosan with W/O/W emulsion technique. Then, the surface morphology was characterized by scanning electron microscope (SEM). Ultrasound-triggered drug release experiments were performed with adjustable intensity and time. In the antitumor experiment in vitro, Ultrasound-assisted drug release from MBs exhibited good treatment of tumor. The results proved the combination of ultrasound and drug-loaded carboxymethyl chitosan microbubbles could be used as a potential strategy for anti-tumor therapy.

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pH-Sensitive N-doped carbon dots–heparin and doxorubicin drug delivery system: preparation and anticancer research

RSC Advances ◽

10.1039/c6ra28345d ◽

2017 ◽

Vol 7 (15) ◽

pp. 9347-9356 ◽

Cited By ~ 29

Author(s):

Ming Zhang ◽

Ping Yuan ◽

Ninglin Zhou ◽

Yutian Su ◽

Maoni Shao ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Delivery System ◽

Delivery System ◽

Carbon Dots ◽

Drug Carrier ◽

Ph Sensitive ◽

Triggered Drug Release ◽

Model Drug ◽

Doped Carbon Dots

In this study, doxorubicin (DOX) hydrochloride as a model drug, N-doped carbon dots as a drug carrier, and heparin as an auxiliary medicine were selected to design and prepare a multi-functional drug delivery system with pH-triggered drug release.

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Dextran-platinum(IV) conjugate as drug carrier for triggered drug release

Journal of Controlled Release ◽

10.1016/j.jconrel.2015.05.160 ◽

2015 ◽

Vol 213 ◽

pp. e96 ◽

Cited By ~ 4

Author(s):

Shasha He ◽

Dongfang Zhou ◽

Huihui Kuang ◽

Yanjuan Wu ◽

Xiabin Jing ◽

...

Keyword(s):

Drug Release ◽

Drug Carrier ◽

Triggered Drug Release

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Covalently Functionalized Carbon Nano-Onions Integrated Gelatin Methacryloyl Nanocomposite Hydrogel Containing γ-Cyclodextrin as Drug Carrier for High-Performance pH-Triggered Drug Release

Pharmaceuticals ◽

10.3390/ph14040291 ◽

2021 ◽

Vol 14 (4) ◽

pp. 291

Author(s):

Narsimha Mamidi ◽

Ramiro Manuel Velasco Delgadillo ◽

Enrique V. Barrera

Keyword(s):

Drug Release ◽

High Performance ◽

Drug Carrier ◽

Controlled Delivery ◽

Supramolecular Hydrogel ◽

Swelling Properties ◽

Human Fibroblast Cells ◽

Future Drug ◽

Acidic Conditions ◽

Triggered Drug Release

Herein, poly (n-(4-aminophenyl) methacrylamide)) carbon nano-onions (PAPMA-CNOs = f-CNOs) and γ-cyclodextrin/DOX-complex (CD) reinforced gelatin methacryloyl (GelMA)/f-CNOs/CD supramolecular hydrogel interfaces were fabricated using the photo-crosslinking technique. The physicochemical properties, morphology, biodegradation, and swelling properties of hydrogels were investigated. The composite hydrogels demonstrated enriched drug release under the acidic conditions (pH 4.5 = 99%, and pH 6.0 = 82%) over 18 days. Owing to the f-CNOs inclusion, GelMA/f-CNOs/CD supramolecular hydrogels presented augmented tensile strength (σult = 356.1 ± 3.4 MPa), toughness (K = 51.5 ± 0.24 Jg−1), and Young’s modulus (E = 41.8 ± 1.4 GPa). The strengthening of GelMA/f-CNOs/CD hydrogel systems indicates its good dispersion and the degree of polymer enveloping of f-CNOs within GelMA matrixes. Furthermore, the obtained hydrogels showed improved cell viability with human fibroblast cells. Nevertheless, the primed supramolecular hydrogels would pave the way for the controlled delivery systems for future drug delivery.

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Biocompatibility and Toxicity of Polylactic Acid/Ferrosoferric Oxide Nanomagnetic Microsphere

Journal of Nanomaterials ◽

10.1155/2017/5429063 ◽

2017 ◽

Vol 2017 ◽

pp. 1-8 ◽

Cited By ~ 3

Author(s):

Hongzhao Xiang ◽

Yuanhua Mu ◽

Chengbo Hu ◽

Xiaobing Luo

Keyword(s):

Liver Cancer ◽

Cancer Cells ◽

Polylactic Acid ◽

Ferric Oxide ◽

Micronucleus Test ◽

Drug Carrier ◽

Liver Cells ◽

Precipitation Method ◽

Liver Cancer Cells ◽

Targeted Drug

Magnetic targeted drugs delivery system (MTDDS) is a new targeted drug system, which can greatly reduce the dosage and improve the therapeutic efficiency of medicine. Currently superparamagnetic ferric oxide plays important function as targeted drug in the treatment of tumors, but cytotoxicity was still regarded as side effect in the process of drug. In this paper, we take advantage of drug carrier (ferric oxide) toxicity controlling cancer cell growth in cancer treatment, increasing targeted drug efficiency. We applied the modified chemical precipitation method to prepare polylactic acid (PLA) coated high-purity superparamagnetic Fe3O4 nanoparticles for targeted drug, characterized PLA/Fe3O4 microspheres physical and chemical properties, and then investigated cytotoxicity influence of PLA/Fe3O4 nanomagnetic microspheres as carrier for normal liver cells (7701) and liver cancer cells (HePG2) in different concentration; results of MTT and hemolysis and micronucleus test showed that carrier restrained the growth of HePG2 in special concentration, meanwhile the proliferation rate of liver cells was not affected. The study demonstrates that compared with liver cell, liver cancer cells (HepG2) are easy to be disturbed by PLA/Fe3O4 nanomagnetic microsphere, which have higher sensitivity and absorption ability. We hope to take advantage of the susceptible property of cancer cells for carriers to improve targeted drug function.

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