High-density lipoprotein in Alzheimer's disease: From potential biomarkers to therapeutics

2021 ◽  
Author(s):  
Yi Jin ◽  
Kudzai Chifodya ◽  
Guochen Han ◽  
Wenxin Jiang ◽  
Yun Chen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Potential Biomarkers

Oxidized plasma high-density lipoprotein is decreased in Alzheimer's disease

2006 ◽  
Vol 41 (10) ◽  
pp. 1542-1547 ◽  
Author(s):  
Constanze Bergt ◽  
Takanari Nakano ◽  
Jochen Ditterich ◽  
Charles DeCarli ◽  
Jason P. Eiserich
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Plasma High Density Lipoprotein ◽  
Plasma High Density

Alteration of high-density lipoprotein functionality in Alzheimer’s disease patients

2017 ◽  
Vol 95 (8) ◽  
pp. 894-903 ◽  
Author(s):  
Paméla Camponova ◽  
Aurélie Le Page ◽  
Hicham Berrougui ◽  
Julie Lamoureux ◽  
Graham Pawelec ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
High Density Lipoprotein ◽  
Healthy Subjects ◽  
Cholesterol Efflux ◽  
Density Lipoprotein ◽  
High Density ◽  
Elderly Subjects ◽  
The Difference

The aims of the present study were to determine whether high-density lipoprotein (HDL) functionality-mediated cholesterol efflux is altered in Alzheimer’s disease and to investigate the role and effect of amyloid-beta (Aβ) in the regulation of the anti-atherogenic activity of HDL. Eighty-seven elderly subjects were recruited, of whom 27 were healthy, 27 had mild cognitive impairment (MCI), and 33 had mild Alzheimer’s disease (mAD). Our results showed that total cholesterol levels are negatively correlated with the Mini-Mental State Examination (MMSE) score (r = –0.2602, p = 0.0182). HDL from the mAD patients was less efficient at mediating cholesterol efflux from J774 macrophages (p < 0.05) than HDL from the healthy subjects and MCI patients. While HDL from the MCI patients was also less efficient at mediating cholesterol efflux than HDL from the healthy subjects, the difference was not significant. Interestingly, the difference between the healthy subjects and the MCI and mAD patients with respect to the capacity of HDL to mediate cholesterol efflux disappeared when ATP-binding cassette transporter A1 (ABCA1)-enriched J774 macrophages were used. HDL fluidity was significantly inversely correlated with the MMSE scores (r = –0.4137, p < 0.009). In vitro measurements of cholesterol efflux using J774 macrophages showed that neither Aβ1-40nor Aβ1-42stimulate cholesterol efflux from unenriched J774 macrophages in basal or ABCA1-enriched J774 macrophages.

scholarly journals An Increased Plasma Level of ApoCIII-Rich Electronegative High-Density Lipoprotein May Contribute to Cognitive Impairment in Alzheimer’s Disease

Biomedicines ◽  
2020 ◽  
Vol 8 (12) ◽  
pp. 542
Author(s):  
Hua-Chen Chan ◽  
Liang-Yin Ke ◽  
Hsiao-Ting Lu ◽  
Shih-Feng Weng ◽  
Hsiu-Chuan Chan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Liquid Chromatography ◽  
Cognitive Impairment ◽  
High Density Lipoprotein ◽  
Cholesterol Efflux ◽  
Density Lipoprotein ◽  
High Density ◽  
Cholesterol Efflux Capacity ◽  
Tnf Α

High-density lipoprotein (HDL) plays a vital role in lipid metabolism and anti-inflammatory activities; a dysfunctional HDL impairs cholesterol efflux pathways. To understand HDL’s role in patients with Alzheimer’s disease (AD), we analyzed the chemical properties and function. HDL from AD patients (AD-HDL) was separated into five subfractions, H1–H5, using fast-protein liquid chromatography equipped with an anion-exchange column. Subfraction H5, defined as the most electronegative HDL, was increased 5.5-fold in AD-HDL (23.48 ± 17.83%) in comparison with the control HDL (4.24 ± 3.22%). By liquid chromatography mass spectrometry (LC/MSE), AD-HDL showed that the level of apolipoprotein (apo)CIII was elevated but sphingosine-1-phosphate (S1P)-associated apoM and anti-oxidative paraoxonase 1 (PON1) were reduced. AD-HDL showed a lower cholesterol efflux capacity that was associated with the post-translational oxidation of apoAI. Exposure of murine macrophage cell line, RAW 264.7, to AD-HDL induced a vibrant expression of ganglioside GM1 in colocalization with apoCIII on lipid rafts alongside a concomitant increase of tumor necrosis factor-α (TNF-α) detectable in the cultured medium. In conclusion, AD-HDL had a higher proportion of H5, an apoCIII-rich electronegative HDL subfraction. The associated increase in pro-inflammatory (apoCIII, TNF-α) components might favor Amyloid β assembly and neural inflammation. A compromised cholesterol efflux capacity of AD-HDL may also contribute to cognitive impairment.

scholarly journals Investigation of the Effects of Biochemical Parameters on Alzheimer’s Disease

2019 ◽  
Vol 34 (7-8) ◽  
pp. 464-468 ◽  
Author(s):  
Mustafa Gokce ◽  
Muhammed Yunus Bektay ◽  
Rabia Selvitop ◽  
Ali Toprak ◽  
Gulsen Babacan Yildiz
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vitamin D ◽  
Folic Acid ◽  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
Glycosylated Hemoglobin ◽  
Density Lipoprotein ◽  
High Density ◽  
Laboratory Findings

Background: The most common type of dementia is an Alzheimer’s disease which is a major concern in growing chronic diseases in the geriatric society, and its connection with biochemistry has not been sufficiently understood. Objective: This study aims to evaluate the effects of blood biochemistry on Alzheimer’s disease. Method: Eight participants aged 55+ with Alzheimer’s disease were analyzed. A cross-sectional work has conducted. Eighty patients have been divided into 2 groups as group A and group B according to laboratory findings including glycosylated hemoglobin, high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol (TC), triglycerides (TGA), vitamin D, folic acid, and vitamin B12. Mean Mini-Mental State Examination scores between these different 2 groups have been compared. Results: High levels of HDL, vitamin D, and folic acid correlate with cognitive scores, whereas high levels of total cholesterol, HbA1c, LDL show a negative effect on cognition scores. Conclusion: High-density lipoprotein, vitamin D, folic acid, cholesterol, HgA1c, and LDL have an effect on dementia.

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