NIR-triggered drug delivery system for chemo-photothermal therapy of posterior capsule opacification

A key challenge for nanoparticles-based drug delivery system is to achieve manageable drug release in tumour cell. In this study, a versatile system combining photothermal therapy and controllable drug release for tumour cells using temperature-sensitive block copolymer coupled Au NRs@SiO2 is reported. While the Au NRs serve as hyperthermal agent and the mesoporous silica was used to improve the drug loading and decrease biotoxicity. The block copolymer acted as “gatekeeper” to regulate the release of model drug (Doxorubicin hydrochloride, DOX). Through in vivo and in vitro experiments, we achieved the truly controllable drug release and photothermal therapy with the collaborative effect of the three constituents of the nanocomposites. The reported nanocomposites pave the way to high-performance controllable drug release and photothermal therapy system.

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A multifunctional near-infrared laser-triggered drug delivery system using folic acid conjugated chitosan oligosaccharide encapsulated gold nanorods for targeted chemo-photothermal therapy

Journal of Materials Chemistry B ◽

10.1039/c8tb02823k ◽

2019 ◽

Vol 7 (24) ◽

pp. 3811-3825 ◽

Cited By ~ 14

Author(s):

Panchanathan Manivasagan ◽

Seung Won Jun ◽

Van Tu Nguyen ◽

Nguyen Thanh Phong Truong ◽

Giang Hoang ◽

...

Keyword(s):

Drug Delivery ◽

Folic Acid ◽

Combination Therapy ◽

Drug Delivery System ◽

Delivery System ◽

Gold Nanorods ◽

Photothermal Therapy ◽

Near Infrared ◽

Infrared Laser ◽

Chitosan Oligosaccharide

FA–COS–TGA–GNRs–DOX have been successfully designed as a drug delivery system for chemo-photothermal combination therapy.

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CuS@mSiO2-PEG core–shell nanoparticles as a NIR light responsive drug delivery nanoplatform for efficient chemo-photothermal therapy

Dalton Transactions ◽

10.1039/c5dt00198f ◽

2015 ◽

Vol 44 (22) ◽

pp. 10343-10351 ◽

Cited By ~ 54

Author(s):

Xijian Liu ◽

Qilong Ren ◽

Fanfan Fu ◽

Rujia Zou ◽

Qian Wang ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Photothermal Therapy ◽

Core Shell ◽

Shell Nanoparticles ◽

Nir Light ◽

Core Shell Nanoparticles

A difunctional nanoplatform (CuS@mSiO2-PEG) acted as a NIR light induced photothermal-triggered drug delivery system for efficient chemo-photothermal therapy.

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Overcoming multidrug resistance by a combination of chemotherapy and photothermal therapy mediated by carbon nanohorns

Journal of Materials Chemistry B ◽

10.1039/c6tb01469k ◽

2016 ◽

Vol 4 (36) ◽

pp. 6043-6051 ◽

Cited By ~ 17

Author(s):

Junling Wang ◽

Ran Wang ◽

Fangrong Zhang ◽

Yajun Yin ◽

Leixia Mei ◽

...

Keyword(s):

Drug Delivery ◽

Multidrug Resistance ◽

Drug Delivery System ◽

Delivery System ◽

Targeted Drug Delivery ◽

Photothermal Therapy ◽

Carbon Nanohorns ◽

P Glycoprotein ◽

Targeted Drug ◽

Targeted Drug Delivery System

A targeted drug delivery system based on carbon nanohorns for targeting P-glycoprotein and delivering etoposide into cells to overcome multidrug resistance.

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