Insights into nucleic acid-based self-assembling nanocarriers for targeted drug delivery and controlled drug release

2021 ◽  
Author(s):  
Keren Chen ◽  
Yangzi Zhang ◽  
Longjiao Zhu ◽  
Huashuo Chu ◽  
Kunlun Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Nucleic Acid ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Controlled Drug Release ◽  
Self Assembling ◽  
Targeted Drug

scholarly journals A photochemical approach for controlled drug release in targeted drug delivery

2012 ◽  
Vol 20 (3) ◽  
pp. 1281-1290 ◽  
Author(s):  
Seok Ki Choi ◽  
Manisha Verma ◽  
Justin Silpe ◽  
Ryan E. Moody ◽  
Kenny Tang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Controlled Drug Release ◽  
Targeted Drug

Potential application of functional porous TiO2 nanoparticles in light-controlled drug release and targeted drug delivery

2015 ◽  
Vol 13 ◽  
pp. 354-363 ◽  
Author(s):  
Tianyi Wang ◽  
Haitao Jiang ◽  
Long Wan ◽  
Qinfu Zhao ◽  
Tongying Jiang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Tio2 Nanoparticles ◽  
Targeted Drug Delivery ◽  
Potential Application ◽  
Controlled Drug Release ◽  
Porous Tio2 ◽  
Targeted Drug

Programmable shape-morphing microrobots for localized cancer cells treatment

2021 ◽  
Author(s):  
Chen Xin ◽  
Dongdong Jin ◽  
Yanlei Hu ◽  
Liang Yang ◽  
Rui Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Biological Applications ◽  
Proof Of Concept ◽  
Ph Responsive ◽  
Solution Ph ◽  
Shape Morphing ◽  
On Demand ◽  
Targeted Drug

Abstract Microrobots have attracted great attentions due to their wide applications in microobjects manipulation and targeted drug delivery. To realize more complex micro/nano cargos manipulation (e.g., encapsulation and release) in biological applications, endowing microrobots with shapes adaptability with the environment is highly desirable. Here, designable shape-morphing microrobots (SMMRs) have been developed by programmatically encoding different expansion rate in a pH-responsive hydrogel. Combined with magnetic propelling, the shape-morphing microcrab (SMMC) is capable of performing targeted microparticle delivery, including gripping, transporting, and releasing through claws morphing. As a proof-of-concept demonstration, the shape-morphing microfish (SMMF) is designed to encapsulate drug (doxorubicin (DOX)) by closing mouth in phosphate buffer saline (PBS, pH~7.4) and release them by opening mouth in slightly acid solution (pH<7), which realize localized Hela cells treatment in an artificial vascular network. These SMMRs with powerful shape morphing capabilities and remote motion controllability provide new platforms for complex microcargos operation and on-demand drug release.

Highly tumor-specific DNA nanostructures discovered by in vivo screening of a nucleic acid cage library and their applications in tumor-targeted drug delivery

Biomaterials ◽  
2019 ◽  
Vol 195 ◽  
pp. 1-12 ◽  
Author(s):  
Kyoung-Ran Kim ◽  
Seong Jae Kang ◽  
A-Young Lee ◽  
Dohyeon Hwang ◽  
Miri Park ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Nucleic Acid ◽  
Targeted Drug Delivery ◽  
Dna Nanostructures ◽  
In Vivo Screening ◽  
Targeted Drug

Light-responsive polymersomes with a charge-switch for targeted drug delivery

2020 ◽  
Vol 8 (4) ◽  
pp. 727-735 ◽  
Author(s):  
Yaowu Zhou ◽  
Rongrong Chen ◽  
Huiting Yang ◽  
Chunyan Bao ◽  
Jinyan Fan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Amphiphilic Polymer ◽  
Targeted Drug ◽  
A Charge

A cationic and lipid-like amphiphilic polymer was designed to form polymersomes for photo-responsive and targeted drug release.

Engineered Polymer–Transferrin Conjugates as Self-Assembling Targeted Drug Delivery Systems

2017 ◽  
Vol 18 (5) ◽  
pp. 1532-1543 ◽  
Author(s):  
Hiteshri Makwana ◽  
Francesca Mastrotto ◽  
Johannes P. Magnusson ◽  
Darrell Sleep ◽  
Joanna Hay ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Self Assembling ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems
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