Light-responsive polymersomes with a charge-switch for targeted drug delivery

2020 ◽  
Vol 8 (4) ◽  
pp. 727-735 ◽  
Author(s):  
Yaowu Zhou ◽  
Rongrong Chen ◽  
Huiting Yang ◽  
Chunyan Bao ◽  
Jinyan Fan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Amphiphilic Polymer ◽  
Targeted Drug ◽  
A Charge

A cationic and lipid-like amphiphilic polymer was designed to form polymersomes for photo-responsive and targeted drug release.

Programmable shape-morphing microrobots for localized cancer cells treatment

2021 ◽  
Author(s):  
Chen Xin ◽  
Dongdong Jin ◽  
Yanlei Hu ◽  
Liang Yang ◽  
Rui Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Biological Applications ◽  
Proof Of Concept ◽  
Ph Responsive ◽  
Solution Ph ◽  
Shape Morphing ◽  
On Demand ◽  
Targeted Drug

Abstract Microrobots have attracted great attentions due to their wide applications in microobjects manipulation and targeted drug delivery. To realize more complex micro/nano cargos manipulation (e.g., encapsulation and release) in biological applications, endowing microrobots with shapes adaptability with the environment is highly desirable. Here, designable shape-morphing microrobots (SMMRs) have been developed by programmatically encoding different expansion rate in a pH-responsive hydrogel. Combined with magnetic propelling, the shape-morphing microcrab (SMMC) is capable of performing targeted microparticle delivery, including gripping, transporting, and releasing through claws morphing. As a proof-of-concept demonstration, the shape-morphing microfish (SMMF) is designed to encapsulate drug (doxorubicin (DOX)) by closing mouth in phosphate buffer saline (PBS, pH~7.4) and release them by opening mouth in slightly acid solution (pH<7), which realize localized Hela cells treatment in an artificial vascular network. These SMMRs with powerful shape morphing capabilities and remote motion controllability provide new platforms for complex microcargos operation and on-demand drug release.

scholarly journals A photochemical approach for controlled drug release in targeted drug delivery

2012 ◽  
Vol 20 (3) ◽  
pp. 1281-1290 ◽  
Author(s):  
Seok Ki Choi ◽  
Manisha Verma ◽  
Justin Silpe ◽  
Ryan E. Moody ◽  
Kenny Tang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Controlled Drug Release ◽  
Targeted Drug

scholarly journals Multi-stimuli responsive smart chitosan-based microcapsules for targeted drug delivery and triggered drug release

2017 ◽  
Vol 38 ◽  
pp. 145-153 ◽  
Author(s):  
Xuejun Cui ◽  
Xinyu Guan ◽  
Shuangling Zhong ◽  
Jie Chen ◽  
Houjuan Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Stimuli Responsive ◽  
Triggered Drug Release ◽  
Targeted Drug

AminoBODIPY Conjugates for Targeted Drug Delivery Systems and Real-Time Monitoring of Drug Release

2021 ◽  
Author(s):  
Martin Porubský ◽  
Soňa Gurská ◽  
Jarmila Stanková ◽  
Marián Hajdúch ◽  
Petr Džubák ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Real Time ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Real Time Monitoring ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems

scholarly journals A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1970 ◽  
Author(s):  
Humaira Idrees ◽  
Syed Zohaib Javaid Zaidi ◽  
Aneela Sabir ◽  
Rafi Ullah Khan ◽  
Xunli Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Natural Polymer ◽  
Natural Polymers ◽  
Sustained Drug Release ◽  
Delivery Methods ◽  
Lower Toxicity ◽  
Targeted Drug

Biodegradable natural polymers have been investigated extensively as the best choice for encapsulation and delivery of drugs. The research has attracted remarkable attention in the pharmaceutical industry. The shortcomings of conventional dosage systems, along with modified and targeted drug delivery methods, are addressed by using polymers with improved bioavailability, biocompatibility, and lower toxicity. Therefore, nanomedicines are now considered to be an innovative type of medication. This review critically examines the use of natural biodegradable polymers and their drug delivery systems for local or targeted and controlled/sustained drug release against fatal diseases.

Peptide‐Driven Targeted Drug‐Delivery System Comprising Turn‐On Near‐Infrared Fluorescent Xanthene–Cyanine Reporter for Real‐Time Monitoring of Drug Release

ChemMedChem ◽  
2019 ◽  
Vol 14 (19) ◽  
pp. 1727-1734 ◽  
Author(s):  
T. M. Ebaston ◽  
Alex Rozovsky ◽  
Alisa Zaporozhets ◽  
Andrii Bazylevich ◽  
Helena Tuchinsky ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Real Time ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Near Infrared ◽  
Turn On ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

Boronate-crosslinked polysaccharide conjugates for pH-responsive and targeted drug delivery

2019 ◽  
Vol 55 (8) ◽  
pp. 1164-1167 ◽  
Author(s):  
Yu-Hui Zhang ◽  
Ying-Ming Zhang ◽  
Jie Yu ◽  
Jie Wang ◽  
Yu Liu
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Anticancer Effect ◽  
Targeted Drug

A polysaccharide nanoconjugate was fabricated from N-(2-aminoethyl)-gluconamide-grafted hyaluronic acid and bortezomib, displaying pH-responsive targeted drug release and higher anticancer effect.

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