Programmable shape-morphing microrobots for localized cancer cells treatment

Abstract Microrobots have attracted great attentions due to their wide applications in microobjects manipulation and targeted drug delivery. To realize more complex micro/nano cargos manipulation (e.g., encapsulation and release) in biological applications, endowing microrobots with shapes adaptability with the environment is highly desirable. Here, designable shape-morphing microrobots (SMMRs) have been developed by programmatically encoding different expansion rate in a pH-responsive hydrogel. Combined with magnetic propelling, the shape-morphing microcrab (SMMC) is capable of performing targeted microparticle delivery, including gripping, transporting, and releasing through claws morphing. As a proof-of-concept demonstration, the shape-morphing microfish (SMMF) is designed to encapsulate drug (doxorubicin (DOX)) by closing mouth in phosphate buffer saline (PBS, pH~7.4) and release them by opening mouth in slightly acid solution (pH<7), which realize localized Hela cells treatment in an artificial vascular network. These SMMRs with powerful shape morphing capabilities and remote motion controllability provide new platforms for complex microcargos operation and on-demand drug release.

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Boronate-crosslinked polysaccharide conjugates for pH-responsive and targeted drug delivery

Chemical Communications ◽

10.1039/c8cc09956a ◽

2019 ◽

Vol 55 (8) ◽

pp. 1164-1167 ◽

Cited By ~ 5

Author(s):

Yu-Hui Zhang ◽

Ying-Ming Zhang ◽

Jie Yu ◽

Jie Wang ◽

Yu Liu

Keyword(s):

Drug Delivery ◽

Hyaluronic Acid ◽

Drug Release ◽

Targeted Drug Delivery ◽

Ph Responsive ◽

Anticancer Effect ◽

Targeted Drug

A polysaccharide nanoconjugate was fabricated from N-(2-aminoethyl)-gluconamide-grafted hyaluronic acid and bortezomib, displaying pH-responsive targeted drug release and higher anticancer effect.

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Polysaccharides for Colon–Targeted Drug Delivery: Improved Drug–Release Specificity and Therapeutic Benefits

Ulcerative Colitis - Treatments, Special Populations and the Future ◽

10.5772/27138 ◽

2011 ◽

Cited By ~ 1

Author(s):

Annette Hartzell ◽

Devin J.

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Targeted Drug Delivery ◽

Therapeutic Benefits ◽

Targeted Drug

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Folic Acid-Terminated Poly(2-Diethyl Amino Ethyl Methacrylate) Brush-Gated Magnetic Mesoporous Nanoparticles as a Smart Drug Delivery System

Polymers ◽

10.3390/polym13010059 ◽

2020 ◽

Vol 13 (1) ◽

pp. 59

Author(s):

Abeer M. Beagan ◽

Ahlam A. Alghamdi ◽

Shatha S. Lahmadi ◽

Majed A. Halwani ◽

Mohammed S. Almeataq ◽

...

Keyword(s):

Drug Delivery ◽

Drug Resistance ◽

Folic Acid ◽

Drug Delivery System ◽

Targeted Drug Delivery ◽

Ph Responsive ◽

Ethyl Methacrylate ◽

Mesoporous Nanoparticles ◽

Targeted Drug ◽

Mcf 7

Currently, chemotherapy is an important method for the treatment of various cancers. Nevertheless, it has many limitations, such as poor tumour selectivity and multi-drug resistance. It is necessary to improve this treatment method by incorporating a targeted drug delivery system aimed to reduce side effects and drug resistance. The present work aims to develop pH-sensitive nanocarriers containing magnetic mesoporous silica nanoparticles (MMSNs) coated with pH-responsive polymers for tumour-targeted drug delivery via the folate receptor. 2-Diethyl amino ethyl methacrylate (DEAEMA) was successfully grafted on MMSNs via surface initiated ARGET atom transfer radical polymerization (ATRP), with an average particle size of 180 nm. The end groups of poly (2-(diethylamino)ethyl methacrylate) (PDEAEMA) brushes were converted to amines, followed by a covalent bond with folic acid (FA) as a targeting agent. FA conjugated to the nanoparticle surface was confirmed by X-ray photoelectron spectroscopy (XPS). pH-Responsive behavior of PDEAEMA brushes was investigated by Dynamic Light Scattering (DLS). The nanoparticles average diameters ranged from ca. 350 nm in basic media to ca. 650 in acidic solution. Multifunctional pH-sensitive magnetic mesoporous nanoparticles were loaded with an anti-cancer drug (Doxorubicin) to investigate their capacity and long-circulation time. In a cumulative release pattern, doxorubicin (DOX) release from nano-systems was ca. 20% when the particle exposed to acidic media, compared to ca. 5% in basic media. The nano-systems have excellent biocompatibility and are minimally toxic when exposed to MCF-7, and -MCF-7 ADR cells.

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Bioinspired navigation in shape morphing micromachines for autonomous targeted drug delivery

2018 IEEE International Conference on Soft Robotics (RoboSoft) ◽

10.1109/robosoft.2018.8404890 ◽

2018 ◽

Author(s):

Hen-Wei Huang ◽

Sean Lyttle ◽

Bradley J. Nelson

Keyword(s):

Drug Delivery ◽

Targeted Drug Delivery ◽

Shape Morphing ◽

Targeted Drug

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A Prototype Therapeutic Capsule Endoscope for Ultrasound-Mediated Targeted Drug Delivery

Journal of Medical Robotics Research ◽

10.1142/s2424905x18400019 ◽

2018 ◽

Vol 03 (02) ◽

pp. 1840001 ◽

Cited By ~ 10

Author(s):

Fraser Stewart ◽

Antonella Verbeni ◽

Yongqiang Qiu ◽

Ben F. Cox ◽

Jan Vorstius ◽

...

Keyword(s):

Drug Delivery ◽

Crohn’S Disease ◽

Side Effects ◽

Capsule Endoscopy ◽

Targeted Drug Delivery ◽

Capsule Endoscope ◽

Proof Of Concept ◽

Gi Tract ◽

Preliminary Results ◽

Targeted Drug

The prevalence of gastrointestinal (GI) diseases such as Crohn’s disease, which is chronic and incurable, are increasing worldwide. Treatment often involves potent drugs with unwanted side effects. The technological–pharmacological combination of capsule endoscopy with ultrasound-mediated targeted drug delivery (UmTDD) described in this paper carries new potential for treatment of these diseases throughout the GI tract. We describe a proof-of-concept UmTDD capsule and present preliminary results to demonstrate its promise as an autonomous tool to treat GI diseases.

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