scholarly journals Hantavirus infection with pulmonary symptoms in north central part of Sri Lanka

2021 ◽  
pp. 100052
Author(s):  
Rohitha Muthugala ◽  
Kalpa Dheerasekara ◽  
Nandika Harischandra ◽  
Darshana Wickramasinghe ◽  
Mudhitha Abeykoon ◽  
...  
Keyword(s):  
Sri Lanka ◽  
Hantavirus Infection ◽  
North Central

Cordyceps dipterigena. [Descriptions of Fungi and Bacteria].

1979 ◽  
Author(s):  
B. L. K. Brady
Keyword(s):  
Sri Lanka ◽  
South America ◽  
Geographical Distribution ◽  
New Guinea ◽  
North Central ◽  
Tropical Countries

Abstract A description is provided for Cordyceps dipterigena. Information is included on the disease caused by the organism, its transmission, geographical distribution, and hosts. HOSTS: Diptera (Muscidae). GEOGRAPHICAL DISTRIBUTION: Widespread in tropical countries; Sri Lanka, Indonesia, New Guinea, North, Central and South America, Japan, Ghana.

scholarly journals Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study

Viruses ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 700 ◽  
Author(s):  
Sarathkumara ◽  
Gamage ◽  
Lokupathirage ◽  
Muthusinghe ◽  
Nanayakkara ◽  
...  
Keyword(s):  
Risk Factor ◽  
Sri Lanka ◽  
Kidney Disease ◽  
Kidney Diseases ◽  
Binary Logistic Regression ◽  
Cross Sectional Study ◽  
Unknown Etiology ◽  
Hantavirus Infection ◽  
Sectional Study ◽  
Cross Sectional

Chronic kidney disease of unknown etiology (CKDu) imposes a substantial burden on public health in Sri Lankan agricultural communities. High seroprevalences of hantavirus have been reported in CKDu patients in several locations of Sri Lanka. We carried out a cross-sectional study followed by an unmatched case-control comparison in two geographically distinct areas of Sri Lanka, Girandurukotte (CKDu endemic) and Kandy (CKDu non-endemic) to determine whether exposure to hantaviruses is a potential risk factor in patients with kidney disease. An indirect immunofluorescent antibody assay using two antigens, Thailand orthohantavirus-infected and recombinant N protein-expressing Vero E6 cells, were used for serodiagnosis. Participants’ demographic and other socio-economic data were collected through a structured questionnaire. Fifty kidney disease patients and 270 controls from Kandy and 104 kidney disease patients and 242 controls from Girandurukotte were examined. Seropositivities were 50% and 17.4% in kidney patients and controls, respectively, in Girandurukotte, and they were 18% and 7% in Kandy. The odds of exposure to hantaviruses were higher for kidney disease patients than for controls in both Girandurukotte (OR:3.66, 95% CI:2.01 to 6.64) and Kandy (OR:2.64, 95% CI:1.07 to 6.54) in binary logistic regression models. According to statistical analysis, individuals exposed to hantaviruses had a higher risk of developing renal impairment. Therefore, hantavirus infection might be an important risk factor for development of kidney disease in Sri Lanka.

scholarly journals The incidence, prevalence and trends of Chronic Kidney Disease and Chronic Kidney Disease of uncertain aetiology (CKDu) in the North Central Province of Sri Lanka: an analysis of 30,566 patients

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Asanga Venura Ranasinghe ◽  
Gardiye Weligamage Gamini Priyantha Kumara ◽  
Ranamuka Henayage Karunarathna ◽  
Ambepitiyawaduge Pubudu De Silva ◽  
Korale Gedara Dilini Sachintani ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Sri Lanka ◽  
Kidney Disease ◽  
Central Province ◽  
North Central ◽  
The North ◽  
North Central Province ◽  
Incidence Prevalence

scholarly journals Association of Hantavirus Infections and Leptospirosis With the Occurrence of Chronic Kidney Disease of Uncertain Etiology in the North Central Province of Sri Lanka: A Prospective Study With Patients and Healthy Persons

2020 ◽  
Vol 10 ◽  
Author(s):  
N. P. Sunil-Chandra ◽  
J. A. A. S. Jayaweera ◽  
W. Kumbukgolla ◽  
M. V. M. L. Jayasundara
Keyword(s):  
Chronic Kidney Disease ◽  
Sri Lanka ◽  
Kidney Disease ◽  
Significant Risk ◽  
Study Groups ◽  
Hantavirus Infection ◽  
Strain Specificity ◽  
Climate Conditions ◽  
Significant Difference ◽  
Uncertain Etiology

Chronic Kidney disease of uncertain etiology (CKDu) has become a significant disease burden, affecting farming community of Sri Lanka and the exact etiology, which could be multifactorial, is not hitherto established. This study is aimed to determine the association of past hantavirus infection and leptospirosis with the occurrence of CKDu. A cohort (n = 179) of known CKDu patients living in high-CKDu prevalent areas of Anuradhapura district of Sri Lanka was compared with a group of 49 healthy, sex-matched younger blood relatives of CKDu patients (control-1) and another 48 healthy, age, and sex-matched individuals living in low-CKDu prevalent area (control-2) of the same district where same life style and climate conditions prevail. Fifty out of 179 (27.9%) CKDu patients, 16/49 (32.7%) of control-1 and 7/48 (14.6%) of control-2 were found positive for IgG antibodies to Puumala, Hantaan or both strains of hantaviruses. Hantaan strain specificity was found to be predominant in all study groups. Hantavirus IgG sero-prevalence of healthy individuals living in low-CKDu prevalent area was significantly lower compared to CKDu patients and healthy younger blood relatives living in high-CKDu prevalent areas (p = 0.03). Past hantavirus infection possesses a significant risk for the occurrence of CKDu (OR = 4.5; 95% CI-3.1-5.4, p = 0.02). In contrast, IgG seroprevalence to hantaviruses was not significantly different in CKDu patients and healthy younger blood relatives living in high-CKDu prevalent areas indicating past hantavirus infection has no association with the occurrence of CKDu or possibly, younger relatives may develop CKDu in subsequent years. Seroprevalence to leptospirosis showed no significant difference between CKDu patients and healthy controls.

Weathering of Monuments at Jethawanaramaya Complex in North-Central, Sri Lanka

2009 ◽  
Vol 83 (5) ◽  
pp. 1024-1030 ◽  
Author(s):  
Amila Sandaruwan RATNAYAKE ◽  
Amarasooriya PITAWALA
Keyword(s):  
Sri Lanka ◽  
North Central

scholarly journals Tubulointerstitial damage as the major pathological lesion in endemic chronic kidney disease among farmers in North Central Province of Sri Lanka

2011 ◽  
Vol 17 (3) ◽  
pp. 213-221 ◽  
Author(s):  
Shanika Nanayakkara ◽  
Toshiyuki Komiya ◽  
Neelakanthi Ratnatunga ◽  
S. T. M. L. D. Senevirathna ◽  
Kouji H. Harada ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Sri Lanka ◽  
Kidney Disease ◽  
Central Province ◽  
North Central ◽  
Pathological Lesion ◽  
Tubulointerstitial Damage ◽  
North Central Province

scholarly journals Two Atypical Cases of Hantavirus Infection: Experience from a Tertiary Care Unit in Sri Lanka

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
S. Rupasinghe ◽  
S. Bowattage ◽  
L. Herath ◽  
A. Rajaratnam
Keyword(s):  
Sri Lanka ◽  
Tertiary Care ◽  
Large Family ◽  
Febrile Illness ◽  
Hantavirus Infection ◽  
Enveloped Viruses ◽  
Rickettsial Infections ◽  
Clinical Syndromes ◽  
Radiological Response ◽  
Epidemiologic Features

Hantaviruses are a large family of enveloped viruses with two medically important families Cricetidae and Muridae which are known to cause rodent-borne diseases worldwide. Some strains cause clinical syndromes with multiorgan involvement in humans such as hantavirus haemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), which is also known as hantavirus pulmonary syndrome. Clinical differentiation of this infection from other endemic infections in Sri Lanka such as leptospirosis and rickettsial infections is extremely difficult due to overlapping clinical and epidemiologic features such as exposure to rodents and farming. Here, we report two serologically confirmed cases of hantavirus infection from Sri Lanka with different presentation. The first patient had a combination of HCPS and HFRS. The second patient was treated for HPS complicated with acute respiratory distress syndrome (ARDS). Both had a significant clinical, biochemical, and radiological response with early initiation of corticosteroids. However, further studies are required to assess whether steroids hasten the recovery of severe hantavirus infections. We believe that hantavirus infection is an important emerging disease in the country and should be considered as a differential diagnosis in patients presenting with an acute febrile illness as well as in patients presenting with ARDS. Early diagnosis and prompt treatment improve prognosis.

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