scholarly journals Mechanism of alveolar bone destruction in periodontitis — Periodontal bacteria and inflammation

2021 ◽  
Vol 57 ◽  
pp. 201-208
Author(s):  
Michihiko Usui ◽  
Satoru Onizuka ◽  
Tsuyoshi Sato ◽  
Shoichiro Kokabu ◽  
Wataru Ariyoshi ◽  
...  
Keyword(s):  
Alveolar Bone ◽  
Bone Destruction ◽  
Periodontal Bacteria

scholarly journals Periodontal Manifestations in a Patient with Haim-Munk Syndrome

2010 ◽  
Vol 04 (03) ◽  
pp. 338-340
Author(s):  
Kamile Erciyas ◽  
Serhat Inaloz ◽  
A. Fuat Erciyas
Keyword(s):  
Autosomal Recessive ◽  
Alveolar Bone ◽  
Bone Destruction ◽  
Autosomal Recessive Disorder ◽  
Aggressive Periodontitis ◽  
Pes Planus ◽  
Rare Autosomal Recessive Disorder ◽  
Rare Anomaly ◽  
Palmoplantar Hyperkeratosis

Haim-Munk syndrome is an extremely rare autosomal recessive disorder characterized clinically by palmoplantar hyperkeratosis, aggressive periodontitis with severe alveolar bone destruction, onychogryphosis, pes planus, arachnodactyly, and acro-osteolysis. Consanguinity seems a notable prerequisite. The aim of this study was therefore to report one case of this syndrome and to focus on the periodontal manifestations, in order to attract the attention of dental clinicians to this rare anomaly. (Eur J Dent 2010;4:338-340)

Cerium oxide nanozyme attenuates periodontal bone destruction by inhibiting ROS-NFκB pathway

Nanoscale ◽  
2022 ◽  
Author(s):  
Yijun Yu ◽  
Sheng Zhao ◽  
Deao Gu ◽  
Bijun Zhu ◽  
Hanxiao Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Bone Resorption ◽  
Inflammatory Disease ◽  
Tissue Damage ◽  
Alveolar Bone ◽  
Bone Destruction ◽  
Oxygen Species ◽  
Nfκb Pathway ◽  
Excess Reactive Oxygen Species

Periodontitis, an inflammatory disease of oxidative stress, occurs due to the excess reactive oxygen species (ROS) contributing to cell and tissue damage that in turn leads to alveolar bone resorption...

scholarly journals Management of Chronic Gingivitis with localized periodontitis by Nonsurgical (Phase I) Periodontal Therapy- A Case Report

2018 ◽  
Vol 7 (2) ◽  
pp. 33-37
Author(s):  
Md Huzzatul Islam Khan ◽  
Sultana Akter Eka ◽  
Md Ashif Iqbal
Keyword(s):  
Phase I ◽  
Oral Hygiene ◽  
Alveolar Bone ◽  
Bone Destruction ◽  
Chronic Inflammatory Disease ◽  
Periodontal Therapy ◽  
Periodontal Treatment ◽  
Periodontal Tissues ◽  
Hygiene Measures ◽  
Tissue Flap

Periodontitis is a chronic inflammatory disease of the periodontal tissues (periodontium) which surround and support the teeth, that results in attachment loss and alveolar bone destruction leads to ultimate tooth loss. It is caused by the bacteria present in dental plaque, which is a tenacious substance that forms on teeth and gingiva just after teeth are brushed. Periodontal treatment is aimed at controlling the infection in order to stop the progression of the disease and to be able to maintain a healthy periodontium. Mechanical debridement of supragingival and subgingival biofilms, together with adequate oral hygiene measures is the standard periodontal therapy. This mechanical subgingi- val biofilm debridement consists of an initial (nonsurgical /phase I) phase involving scaling and root planing (SRP) and the elimination of plaque retentive factors, followed by a surgical phase (if needed) including the elevation of a tissue flap and bone remodeling in further stages. The adjunct use of antibiotics has proven to additionally improve the outcome of periodontal treatment. A clinical case of a 40-years-old male patient with generalized severe chronic periodontitis with localized gingival swell- ing was treated with nonsurgical (phase I) periodontal therapy that was confined to oral hygiene instruction (OHI), SRP with an adjunct antimicrobial regimen.Update Dent. Coll. j: 2017; 7 (2): 33-37

scholarly journals MicroRNA sequence analysis identifies microRNAs associated with peri-implantitis in dogs

2017 ◽  
Vol 37 (5) ◽  
Author(s):  
Xiaolin Wu ◽  
Xipeng Chen ◽  
Wenxiang Mi ◽  
Tingting Wu ◽  
Qinhua Gu ◽  
...  
Keyword(s):  
Sequence Analysis ◽  
Target Genes ◽  
Alveolar Bone ◽  
Biological Effects ◽  
Bone Destruction ◽  
Mapk Signaling ◽  
Differentially Expressed ◽  
Mitogen Activated Protein Kinase ◽  
Mirna Sequence ◽  
Differentially Expressed Mirnas

Peri-implantitis, which is characterized by dense inflammatory infiltrates and increased osteoclast activity, can lead to alveolar bone destruction and implantation failure. miRNAs participate in the regulation of various inflammatory diseases, such as periodontitis and osteoporosis. Therefore, the present study aimed to investigate the differential expression of miRNAs in canine peri-implantitis and to explore the functions of their target genes. An miRNA sequence analysis was used to identify differentially expressed miRNAs in peri-implantitis. Under the criteria of a fold-change >1.5 and P<0.01, 8 up-regulated and 30 down-regulated miRNAs were selected for predictions of target genes and their biological functions. Based on the results of Gene Ontology (GO) and KEGG pathway analyses, these miRNAs may fine-tune the inflammatory process in peri-implantitis through an intricate mechanism. The results of quantitative real-time PCR (qRT-PCR) revealed that let-7g, miR-27a, and miR-145 may play important roles in peri-implantitis and are worth further investigation. The results of the present study provide insights into the potential biological effects of the differentially expressed miRNAs, and specific enrichment of target genes involved in the mitogen-activated protein kinase (MAPK) signaling pathway was observed. These findings highlight the intricate and specific roles of miRNAs in inflammation and osteoclastogenesis, both of which are key aspects of peri-implantitis, and thus may contribute to future investigations of the etiology, underlying mechanism, and treatment of peri-implantitis.

scholarly journals NADPH Oxidase Contributes to Resistance against Aggregatibacter actinomycetemcomitans-Induced Periodontitis in Mice

2016 ◽  
Vol 85 (2) ◽  
Author(s):  
Antje Bast ◽  
Helen Kubis ◽  
Birte Holtfreter ◽  
Silvia Ribback ◽  
Heiner Martin ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Oral Cavity ◽  
Nadph Oxidase ◽  
Bone Mineral ◽  
Alveolar Bone ◽  
Bone Destruction ◽  
Bone Volume ◽  
Mineral Density ◽  
Content Type

ABSTRACT Aggregatibacter actinomycetemcomitans is a Gram-negative commensal bacterium of the oral cavity which has been associated with the pathogenesis of periodontitis with severe alveolar bone destruction. The role of host factors such as reactive oxygen and nitrogen intermediates in periodontal A. actinomycetemcomitans infection and progression to periodontitis is still ill-defined. Therefore, this study aimed to analyze the role of NADPH oxidase and inducible nitric oxide synthase (iNOS) in a murine model of A. actinomycetemcomitans-induced periodontitis. NADPH oxidase-deficient (gp91phox knockout [KO]), iNOS-deficient (iNOS KO), and C57BL/6 wild-type mice were orally infected with A. actinomycetemcomitans and analyzed for bacterial colonization at various time points. Alveolar bone mineral density and alveolar bone volume were quantified by three-dimensional micro-computed tomography, and the degree of tissue inflammation was calculated by histological analyses. At 5 weeks after infection, A. actinomycetemcomitans persisted at significantly higher levels in the murine oral cavities of infected gp91phox KO mice than in those of iNOS KO and C57BL/6 mice. Concomitantly, alveolar bone mineral density was significantly lower in all three infected groups than in uninfected controls, but with the highest loss of bone density in infected gp91phox KO mice. Only infected gp91phox KO mice revealed significant loss of alveolar bone volume and enhanced inflammatory cell infiltration, as well as an increased number of osteoclasts. Our results indicate that NADPH oxidase is important to control A. actinomycetemcomitans infection in the murine oral cavity and to prevent subsequent alveolar bone destruction and osteoclastogenesis.

The retrieval of a surgical blade broken within the alveolar bone during minimally traumatic tooth extraction

2021 ◽  
Vol 14 (1) ◽  
pp. e240162
Author(s):  
Eldo Koshy ◽  
Lovely M Annamma ◽  
Biji Thomas George ◽  
Godfred Antony Menezes
Keyword(s):  
Dental Implant ◽  
Tooth Extraction ◽  
Alveolar Bone ◽  
Bone Destruction ◽  
Expansion Procedure ◽  
Bone Expansion ◽  
Scalpel Blade ◽  
Atraumatic Extraction ◽  
Tooth Removal

Minimally traumatic tooth removal is the norm for removing teeth when a dental implant is planned at that site. The quantity of available bone is the primary requisite to place an implant. The initial use of a scalpel blade to widen the periodontal space followed by the use of luxators is one of the techniques that is being followed for atraumatic extraction. A case of accidental breakage of a number 11 scalpel blade while attempting tooth removal and the method adopted in removing this portion of the blade without further bone destruction is reported here. The authors have not found any previously published cases, reporting the breakage of a scalpel blade during the bone expansion procedure and its management.

scholarly journals Salivary Osteocalcin as Potential Diagnostic Marker of Periodontal Bone Destruction among Smokers

Biomolecules ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 380
Author(s):  
Betsy Joseph ◽  
Mukhatar Ahmed Javali ◽  
Mohasin Abdul Khader ◽  
Saad M. AlQahtani ◽  
Amanullah Mohammed
Keyword(s):  
Type I Collagen ◽  
Alveolar Bone ◽  
Diagnostic Marker ◽  
Bone Destruction ◽  
Alveolar Bone Loss ◽  
Youden Index ◽  
Type I ◽  
Healthy Controls ◽  
Pocket Depth ◽  
Probing Pocket Depth

The objective of the study was to assess the levels and diagnostic accuracy of salivary osteocalcin (OC), osteonectin (ON), and deoxypyridinoline-containing degradation fragment of the C-terminal telopeptide region of type I collagen (CTX) in adult smokers with periodontal bone destruction. Towards this, ninety systemically healthy patients (groups I: healthy, II: periodontitis with non-smokers, and III: periodontitis with current smokers) were included in the study. The results showed a positive correlation (weak to moderate) was observed for OC, ON, and CTX with probing pocket depth (PPD; r = 0.40, 0.32, and 0.36) and alveolar bone loss (BL; r = 0.58, 0.38, and 0.51) (p < 0.01). Smoker periodontitis was best discriminated from healthy controls using 15.25 ng/mL of OC (AUC: 0.870; 95% CI: 0.757–0.943; YI (Youden Index): 0.693; p < 0.0001). However, with a cut-off of BL at 33.33%, 19.24 ng/mL of salivary OC gave the best discrimination (AUC: 0.809; 95% CI: 0.686–0.900; Se: 80.0%; Sp: 73.47%, and YI: 0.534). A 16.45 ng/mL amount of OC gave excellent discrimination (AUC: 0.811; 95% CI: 0.688–0.901; Se: 92.31%; Sp: 65.22%, and YI: 0.575) among healthy and smoker periodontitis when PD at 6mm was considered as cut-off. Conclusion: The best discrimination between healthy controls and smoker periodontitis was obtained at 15.25 ng/mL of salivary OC.

Alveolar bone destruction in the immunosuppressed rat

1982 ◽  
Vol 17 (3) ◽  
pp. 263-274 ◽  
Author(s):  
K. Sallay ◽  
F. Sanavi ◽  
I. Ring ◽  
P. Pham ◽  
U. H. Behling ◽  
...  
Keyword(s):  
Alveolar Bone ◽  
Bone Destruction
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