Protective effect of Actiniopteris radiata (Sw.) Link. against CCl4 induced oxidative stress in albino rats

2014 ◽  
Vol 153 (3) ◽  
pp. 744-752 ◽  
Author(s):  
Manjunath Manubolu ◽  
Lavanya Goodla ◽  
Sivajyothi Ravilla ◽  
Jayakumar Thanasekaran ◽  
Paresh Dutta ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Albino Rats

scholarly journals Effects of Safranal on Tissue Oxidative Stress in Sub-Chronic Thinner-Addicted Rats

2020 ◽  
Vol 71 (1) ◽  
pp. 1997
Author(s):  
M. DÜZ ◽  
A. F. FIDAN
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Protective Effect ◽  
Total Antioxidant Capacity ◽  
Reduced Glutathione ◽  
Control Group ◽  
Albino Rats ◽  
Total Antioxidant ◽  
Wistar Albino Rats ◽  
And Oxidative Stress

The present study was carried out to determine the effects of sub-chronic thinner addiction on the oxidant-antioxidant balance and oxidative stress on certain tissues and the possible protective effect of safranal against thinner toxication in rats. Adult male Wistar albino rats were randomly divided into four groups of 10 animals each as follows: control (C), safranal (S), thinner (T) and thinner+safranal (T+S). The control group received 1cc saline by gastric gavage. Safranal was administered to S and T+S groups by using gastric gavage at a dose of 100 mg/kg/day and volume of 0.1 mL/kg/day. Thinner inhalation was applied to T and T+S groups in a container with NaOH tablets twice a day. Levels of malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide (NOx) metabolites, total antioxidant capacity (TAS) and total oxidant capacity (TOS) were determined in liver, lung, brain, kidney and testis tissues of the rats. In the T+S group, it was observed that the MDA levels significantly decreased in all tissues, except the kidney, in comparison to the thinner inhalation group (p = 0.000). When the NOx levels of the T+S group were compared with the levels of the T group, it was concluded that there existed a statistically significant decrease in the NOx levels in alltissues (p = 0.000). In T+S group, it was observed that safranal either eliminated or mitigated oxidative stress that developed in tissues through decreasing MDA and TOS levels and increasing GSH and TAS levels and caused significant decreases in NOX levels in all tissues. As a result, it was determined that safranal, although not uniform for all tissue types, had a protective potential against the damaging effects of oxidative stress caused by sub-chronic thinner inhalation.

scholarly journals Protective Effect of Caffeic Acid Phenethyl Ester on Antituberculosis Drug-Induced Hepatotoxicity in Rats

2018 ◽  
Vol 102 (9-10) ◽  
pp. 473-478 ◽  
Author(s):  
Cigdem Aliosmanoglu ◽  
Halil Erbiş ◽  
Ibrahim Aliosmanoglu ◽  
Mehmet Akif Türkoglu ◽  
Burak Veli Ulger ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Trace Elements ◽  
Protective Effect ◽  
Caffeic Acid ◽  
Liver Function Tests ◽  
Caffeic Acid Phenethyl Ester ◽  
Stress Index ◽  
Albino Rats ◽  
Drug Induced ◽  
Antituberculosis Treatment

Isoniazid and rifampicin are drugs primarily used in antituberculosis treatment. Our aim in this study is to evaluate the effect of caffeic acid phenethyl ester's protective effect on liver function tests and to trace elements in hepatic damage caused by isoniazid and rifampicin on rats. Forty Wistar albino rats were divided into 4 groups. Group 1: Sham, Group 2: caffeic acid phenethyl ester application, Group 3: isoniazid and rifampicin given, Group 4: isoniazid + rifampicin and caffeic acid phenethyl ester application. After 30 days, the rats were sacrificed by taking blood from the heart. Alanine aminotransferase, aspartate aminotransferase, zinc, copper, total antioxidant capacity, total oxidative status, and oxidative stress index levels were evaluated. The rats to which isoniazid + rifampicin+ caffeic acid phenethyl ester were given had less oxidative stress and copper levels (P < 0.001, P = 0.019) but have higher zinc levels (P = 0.001) compared to the isoniazid + rifampicin group. Liver enzyme levels were also lower in rats that were given isoniazid + rifampicin + caffeic acid phenethyl ester (P < 0.001). The results of this study suggested that caffeic acid phenethyl ester influences the levels of trace elements (copper and zinc) that are important for the physiologic mechanisms of organisms, reducing liver damage.

Protective effect of Crataeva nurvala bark against MNU and testosterone induced oxidative stress in liver of male albino rats

2012 ◽  
Vol 2 (3) ◽  
pp. 94-98
Author(s):  
Dugganaboyana Guru Kumar ◽  
Purandekkattil Deepa ◽  
Muthaiyan Ahalliya Rathi ◽  
Periasamy Meenakshi ◽  
Velliyur Kanniappan Gopalakrishnan
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Albino Rats

Methotrexate-Induced Nephrotoxicity in Rats: Protective Effect of Mistletoe (Viscum album L.) Extract

2017 ◽  
Vol 24 (6) ◽  
pp. 364-370 ◽  
Author(s):  
Esin Sakalli Çetin ◽  
Hasan Tetiker ◽  
Özgür İlhan Çelik ◽  
Nigar Yılmaz ◽  
İbrahim Hakkı Ciğerci
Keyword(s):  
Oxidative Stress ◽  
Comet Assay ◽  
Protective Effect ◽  
Viscum Album ◽  
Control Group ◽  
Albino Rats ◽  
Histopathological Analysis ◽  
Mistletoe Extract ◽  
Group 10 ◽  
Group 5

Background: The protective effect of mistletoe extract (Helixor®, HLX) against methotrexate (MTX)-induced acute oxidative stress and nephrotoxicity in rats was evaluated by histological and biochemical methods as well as the comet assay. Material and Methods: 32 female Wistar albino rats were divided into 4 groups: control group, HLX group (5 mg/kg body weight (bw), days 1-10, intraperitoneally (i.p.)), MTX group (10 mg/kg bw, days 7, 8, and 9, i.p.), and MTX + HLX group (10 mg/kg bw, days 7, 8, and 9, i.p. + 5 mg/kg bw, days 1-10, i.p.). At the end of the experiment, the glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), nitric oxide (NO), and myeloperoxidase (MPO) levels were measured, and a histopathological analysis and comet assay were carried out. Results: MTX induced renal oxidative stress and nephrotoxicity in the rats. Pretreatment with HLX significantly improved the renal GSH-Px and SOD activities in the MTX + HLX group compared to the MTX group. The decrease in the NO and MPO levels in the rat groups pretreated with HLX was not significant. The histochemical evaluation revealed that HLX provided significant improvement in the MTX-induced renal degenerative changes, including tubule distension, interstitial inflammation, perirenal inflammation, glomerular congestion, glomerular degeneration, and parenchymal hemorrhage, in the MTX + HLX group compared to the MTX-administered group. According to the comet assay, pretreatment with HLX lowered the MTX-induced DNA damage in endogenous lymphocytes, although not significantly. Conclusion: This study demonstrated that HLX administration markedly reduced the MTX-induced acute oxidative stress and nephrotoxicity in rats through its antioxidant and anti-inflammatory properties.

scholarly journals Protective effect of pineapple (Ananas cosmosus) peel extract on alcohol–induced oxidative stress in brain tissues of male albino rats

2011 ◽  
Vol 1 (1) ◽  
pp. 5-9 ◽  
Author(s):  
Ochuko L Erukainure ◽  
John A Ajiboye ◽  
Rachael O Adejobi ◽  
Oluwatoyin Y Okafor ◽  
Sunday O Adenekan
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Albino Rats ◽  
Peel Extract ◽  
Brain Tissues

scholarly journals The Protective Effect of Naringenin-Oxime on Cisplatin-Induced Toxicity in Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Ismail Koyuncu ◽  
Abdurrahim Kocyigit ◽  
Ataman Gonel ◽  
Erkan Arslan ◽  
Mustafa Durgun
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Comet Assay ◽  
Protective Effect ◽  
Stress Index ◽  
Mononuclear Leukocytes ◽  
Albino Rats ◽  
Peripheral Blood Mononuclear ◽  
Liver And Kidney ◽  
And Oxidative Stress

The aim of this study is to examine the protective effect of naringenin-oxime (NOX) on cisplatin-induced major organ toxicity and DNA damage in rats. Thirty-five male Wistar albino rats were equally split into five groups as follows: control (i.p., 0.1 ml of saline), Cis administration (i.p., 7 mg/kg b.w.), NOX treatment (i.p., 20 mg/kg b.w., daily for ten days), Cis + NOX20, and Cis + NOX40 combination (i.p., 20 and 40 mg/kg b.w., daily for ten days). Serum and peripheral blood mononuclear leukocytes (PBMC) were obtained from blood. Malondialdehyde, glutathione, total antioxidant and oxidant status, and catalase were measured in serum, liver, and kidney, and oxidative stress index was calculated. In parallel, paraoxonase and arylesterase activities were tested in liver and serum. We used 8-OHdOG as a marker for DNA damage in serum via ELISA and in PMBC via comet assay. Treatment with Cis elevated the levels of serum biochemical parameters, oxidative stress, and DNA damage. Pretreatments of NOX restored biochemical and oxidative stress parameters in serum, renal, and liver tissues (p<0.01) and reduced 8-OHdG level, a finding further supported by comet assay in PBMC. Observations of the present study support the fact that treatment with NOX prevents Cis-induced hepatotoxicity, nephrotoxicity, and genotoxicity by restoring antioxidant system.

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