Evaluation of anti-inflammatory, analgesic and TNF-α inhibition (upon RAW 264.7 cell line) followed by the selection of extract (leaf and stem) with respect to potency to introduce anti-oral-ulcer model obtained from Olax psittacorum (Lam.) Vahl in addition to GC-MS illustration

2020 ◽  
Vol 263 ◽  
pp. 113146
Author(s):  
Raja Majumder ◽  
Lopamudra Adhikari ◽  
Moonmun Dhara ◽  
Jinamitra Sahu
Keyword(s):  
Cell Line ◽  
Oral Ulcer ◽  
Raw 264.7 ◽  
Raw 264.7 Cell ◽  
Tnf Α ◽  
Ulcer Model ◽  
Anti Inflammatory ◽  
Raw 264.7 Cell Line ◽  
Selection Of

scholarly journals A New Bithiophene from the Root of Echinops grijsii

2015 ◽  
Vol 10 (12) ◽  
pp. 1934578X1501001 ◽  
Author(s):  
Fang-Pin Chang ◽  
Chien-Chih Chen ◽  
Hui-Chi Huang ◽  
Sheng-Yang Wang ◽  
Jih-Jung Chen ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Cell Line ◽  
Natural Source ◽  
Inflammatory Activity ◽  
Raw 264.7 ◽  
Raw 264.7 Cell ◽  
Anti Inflammatory ◽  
First Time ◽  
Raw 264.7 Cell Line

A new bithiophene, 5-(4-hydroxy-3-methoxy-1-butyny)-2,2′-bithiophene (1), and sixteen known thiophenes: 2-(3,4-dihydroxybut-1-ynyl)-5-(penta-1,3-diynyl)thiophene (2), α-terthienyl (3), 5-(3,4-dihydroxybut-1-ynyl)-2,2′-bithiophene (4), 5-acetyl-2,2′-bithiophene (5), 5-formyl-2,2′-bithiophene (6), methyl 2,2′-bithiophene-5-carboxylate (7), 5-(but-3-en-1-ynyl)-2,2′-bithiophene (8), 5-(4-isovaleroyloxybut-1-ynyl)-2,2′-bithiophene (9), cardopatine (10), isocardopatine (11), 5-(3-hydroxy-4-isovaleroyloxybut-1-ynyl)-2,2′-bithiophene (12), 5-(3-hydroxymethyl-3-isovaleroyloxyprop-1-ynyl)-2,2′-bithiophene (13), 5-(4-hydroxy-1-butynyl)-2,2′-bithiophene (14), 5-(4-acetoxy-1-butynl)-2,2′-bithiophene (15), 2,2′-bithiophene-5-carboxylic acid (16) and 2-(4-hydroxybut-1-ynyl)-5-(penta-1,3-diynyl)thiophene (17) were isolated from the roots of Echinops grijisii Hance. Among them, compounds 6, 7 and 16 were isolated from a natural source for the first time. Compounds 2, 4 and 14 exhibited significant anti-inflammatory activity against nitrite of LPS-stimulated production in the RAW 264.7 cell line.

scholarly journals Exposure to particle debris generated from passenger and truck tires induces different genotoxicity and inflammatory responses in the RAW 264.7 cell line

PLoS ONE ◽  
2019 ◽  
Vol 14 (9) ◽  
pp. e0222044 ◽  
Author(s):  
Anna Poma ◽  
Giulia Vecchiotti ◽  
Sabrina Colafarina ◽  
Osvaldo Zarivi ◽  
Lorenzo Arrizza ◽  
...  
Keyword(s):  
Cell Line ◽  
Inflammatory Responses ◽  
Raw 264.7 ◽  
Raw 264.7 Cell ◽  
Truck Tires ◽  
Raw 264.7 Cell Line

Winter urban air particles from Rome (Italy): Effects on the monocytic–macrophagic RAW 264.7 cell line

2005 ◽  
Vol 99 (3) ◽  
pp. 344-354 ◽  
Author(s):  
Roberta Pozzi ◽  
Barbara De Berardis ◽  
Luigi Paoletti ◽  
Cecilia Guastadisegni
Keyword(s):  
Cell Line ◽  
Urban Air ◽  
Raw 264.7 ◽  
Raw 264.7 Cell ◽  
Raw 264.7 Cell Line

Exposure to radiation from single or combined radio frequencies provokes macrophage dysfunction in the RAW 264.7 cell line

2018 ◽  
Vol 94 (6) ◽  
pp. 607-618 ◽  
Author(s):  
Alberto López-Furelos ◽  
Aarón A. Salas-Sánchez ◽  
Francisco J. Ares-Pena ◽  
José M. Leiro-Vidal ◽  
Elena López-Martín
Keyword(s):  
Cell Line ◽  
Raw 264.7 ◽  
Raw 264.7 Cell ◽  
Macrophage Dysfunction ◽  
Radio Frequencies ◽  
Raw 264.7 Cell Line

A far-red to NIR emitting ultra-sensitive probe for the detection of endogenous HOCl in zebrafish and the RAW 264.7 cell line

2019 ◽  
Vol 17 (14) ◽  
pp. 3538-3544 ◽  
Author(s):  
Vijay Natarajan ◽  
Natesan Thirumalaivasan ◽  
Shu-Pao Wu ◽  
Velmathi Sivan
Keyword(s):  
Cell Line ◽  
Fluorescence Imaging ◽  
Raw 264.7 ◽  
Raw 264.7 Cell ◽  
Endogenous Fluorescence ◽  
Line P ◽  
Raw 264.7 Cell Line

We report the synthesis of a far-red to NIR emitting probe for its application to the endogenous fluorescence imaging of HOCl in zebrafish.

scholarly journals Sec-O-glucosylhamaudol suppressed inflammatory reaction induced by LPS in RAW264.7 cells through inhibition of NF-κB and MAPKs signaling

2020 ◽  
Vol 40 (2) ◽  
Author(s):  
Guiming Liu ◽  
Jing Xie ◽  
Yurui Shi ◽  
Rongda Chen ◽  
Li Li ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bioactive Compound ◽  
Therapeutic Effects ◽  
Raw 264.7 ◽  
Pcr Assay ◽  
Raw 264.7 Cell ◽  
Tnf Α ◽  
Anti Inflammatory ◽  
Saposhnikovia Divaricata ◽  
Inflammation Cytokines

Abstract As a major bioactive compound from the Saposhnikovia divaricata (Turcz.) Schischk, sec-O-glucosylhamaudol (SOG), has been reported to have anti-nociceptive activity and high 5-lipoxygenase (5-LOX) activity. Nevertheless, the mechanism of the potential anti-inflammatory effects of SOG is unclear. The anti-inflammatory impacts of SOG in RAW 264.7 cell lines stimulated by LPS were explored in the present study. It was found that SOG dose-dependently reduced the emergence of inflammation cytokines, such as IL-6 and TNF-α in Raw264.7 murine macrophages stimulated by LPS. Real-time PCR assay demonstrated the SOG dose-dependently inhibited transcription of these cytokines as well. In addition, it was also found that NF-κB activation and MAPKs phosphorylation including p38, JNK and ERK1/2 induced by LPS were suppressed by SOG. Due to its anti-inflammatory activity, our results suggest that SOG might have therapeutic effects on inflammatory disease, such as acute lung injury or rheumatoid arthritis.

scholarly journals Effects of Sibseonsan as an Anti-Inflammatory, Anti-Wrinkle, and Skin Whitening Treatment

2020 ◽  
Vol 37 (2) ◽  
pp. 88-93
Author(s):  
Na Young Jo
Keyword(s):  
Treatment Group ◽  
Cell Line ◽  
Radical Scavenging ◽  
Raw 264.7 Cells ◽  
No Production ◽  
Raw 264.7 ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Tnf Α ◽  
Anti Inflammatory

Background: The purpose of this study was to investigate whether Sibseonsan (SSS) is an effective anti-inflammatory, anti-wrinkling, and whitening agent.Methods: To determine whether SSS had an anti-inflammatory effect, a murine macrophage cell line was used (RAW 264.7) and production of DPPH, NO, TNF-α, and PGE2 were measured. To ascertain potential anti-wrinkle effects of SSS in these cells, collagenase and elastase production were measured. To verify whether SSS had a whitening effect, tyrosinase activity and DOPA staining were performed using a melanoma cell line (B16/F10).Results: There was no significant reduction in survival of SSS-treated RAW 264.7 cells, up to 400 μg/mL. Free radical scavenging (23.96 ± 1.85%) was observed in RAW 264.7 cells treated with SSS at a concentration of 400 μg/mL. The SSS treatment group (400 μg/mL) significantly inhibited NO production compared with the LPS stimulated treatment group. The SSS treatment of macrophage cells appeared to reduce production of TNF-α in a concentration dependent manner. There was a significant reduction in the concentration of PGE<sub>2</sub> by about 25% in the SSS treatment (400 μg/mL) group (<i>p</i> = 0.05). Compared with the control, the production of collagenase and elastase in B16/F10 cells treated with SSS (400 μg/mL) was greater by 26.37% and 45.71%, respectively. The SSS treatment (400 μg/mL) group showed a significant reduction by about 17% in tyrosinase production in B16/F10 cells. The SSS treatment group showed little change in DOPA staining.<br>Conclusion: SSS extract may be useful for the treatment and prevention of inflammatory diseases and may have anti-wrinkle and whitening effects. These results may support the use of SSS in clinical practice.

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