Inhibitory effects of Gymnema inodorum (Lour.) Decne leaf extracts and its triterpene saponin on carbohydrate digestion and intestinal glucose absorption

2021 ◽  
Vol 266 ◽  
pp. 113398
Author(s):  
Wanwisa Srinuanchai ◽  
Rawiwan Nooin ◽  
Pornsiri Pitchakarn ◽  
Jirarat Karinchai ◽  
Uthaiwan Suttisansanee ◽  
...  
Keyword(s):  
Glucose Absorption ◽  
Inhibitory Effects ◽  
Leaf Extracts ◽  
Triterpene Saponin ◽  
Intestinal Glucose Absorption ◽  
Carbohydrate Digestion

scholarly journals Flavonoids as Human Intestinal α-Glucosidase Inhibitors

Foods ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1939
Author(s):  
Elizabeth Barber ◽  
Michael J. Houghton ◽  
Gary Williamson
Keyword(s):  
Glucose Absorption ◽  
Inhibitory Effects ◽  
Antidiabetic Drug ◽  
Glucosidase Inhibitors ◽  
Acarbose Treatment ◽  
Ic50 Values ◽  
Intestinal Glucose Absorption ◽  
Inhibition Pattern ◽  
Carbohydrate Digestion ◽  
Enzyme Source

Certain flavonoids can influence glucose metabolism by inhibiting enzymes involved in carbohydrate digestion and suppressing intestinal glucose absorption. In this study, four structurally-related flavonols (quercetin, kaempferol, quercetagetin and galangin) were evaluated individually for their ability to inhibit human α-glucosidases (sucrase, maltase and isomaltase), and were compared with the antidiabetic drug acarbose and the flavan-3-ol(−)-epigallocatechin-3-gallate (EGCG). Cell-free extracts from human intestinal Caco-2/TC7 cells were used as the enzyme source and products were quantified chromatographically with high accuracy, precision and sensitivity. Acarbose inhibited sucrase, maltase and isomaltase with IC50 values of 1.65, 13.9 and 39.1 µM, respectively. A similar inhibition pattern, but with comparatively higher values, was observed with EGCG. Of the flavonols, quercetagetin was the strongest inhibitor of α-glucosidases, with inhibition constants approaching those of acarbose, followed by galangin and kaempferol, while the weakest were quercetin and EGCG. The varied inhibitory effects of flavonols against human α-glucosidases depend on their structures, the enzyme source and substrates employed. The flavonols were more effective than EGCG, but less so than acarbose, and so may be useful in regulating sugar digestion and postprandial glycaemia without the side effects associated with acarbose treatment.

Artocarpus lacucha Extract and Oxyresveratrol Inhibit Glucose Transporters in Human Intestinal Caco-2 Cells

Planta Medica ◽  
2021 ◽  
Author(s):  
Matusorn Wongon ◽  
Nanteetip Limpeanchob
Keyword(s):  
Glucose Transport ◽  
Glucose Transporter ◽  
Glucose Transporters ◽  
Glucose Absorption ◽  
Culture Conditions ◽  
Glucose Transporter 1 ◽  
Glucose Transporter 2 ◽  
Sodium Dependent ◽  
Intestinal Glucose Absorption ◽  
Carbohydrate Digestion

AbstractReduction of intestinal glucose absorption might result from either delayed carbohydrate digestion or blockage of glucose transporters. Previously, oxyresveratrol was shown to inhibit α-glucosidase, but its effect on glucose transporters has not been explored. The present study aimed to assess oxyresveratrol-induced inhibition of the facilitative glucose transporter 2 and the active sodium-dependent glucose transporter 1. An aqueous extract of Artocarpus lacucha, Puag Haad, which is oxyresveratrol-enriched, was also investigated. Glucose transport was measured by uptake into Caco-2 cells through either glucose transporter 2 or sodium-dependent glucose transporter 1 according to the culture conditions. Oxyresveratrol (40 to 800 µM) dose-dependently reduced glucose transport, which appeared to inhibit both glucose transporter 2 and sodium-dependent glucose transporter 1. Puag Haad at similar concentrations also inhibited these transporters but with greater efficacy. Oxyresveratrol and Puag Haad could help reduce postprandial hyperglycemic peaks, which are considered to be most damaging in diabetics.

scholarly journals Mechanisms of Glucose Absorption in the Small Intestine in Health and Metabolic Diseases and Their Role in Appetite Regulation

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2474
Author(s):  
Lyudmila V. Gromova ◽  
Serguei O. Fetissov ◽  
Andrey A. Gruzdkov
Keyword(s):  
Small Intestine ◽  
Blood Glucose ◽  
Metabolic Diseases ◽  
Glucose Absorption ◽  
Cellular Mechanisms ◽  
Physiological Conditions ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
New Strategy ◽  
Intestinal Glucose Absorption

The worldwide prevalence of metabolic diseases such as obesity, metabolic syndrome and type 2 diabetes shows an upward trend in recent decades. A characteristic feature of these diseases is hyperglycemia which can be associated with hyperphagia. Absorption of glucose in the small intestine physiologically contributes to the regulation of blood glucose levels, and hence, appears as a putative target for treatment of hyperglycemia. In fact, recent progress in understanding the molecular and cellular mechanisms of glucose absorption in the gut and its reabsorption in the kidney helped to develop a new strategy of diabetes treatment. Changes in blood glucose levels are also involved in regulation of appetite, suggesting that glucose absorption may be relevant to hyperphagia in metabolic diseases. In this review we discuss the mechanisms of glucose absorption in the small intestine in physiological conditions and their alterations in metabolic diseases as well as their relevance to the regulation of appetite. The key role of SGLT1 transporter in intestinal glucose absorption in both physiological conditions and in diabetes was clearly established. We conclude that although inhibition of small intestinal glucose absorption represents a valuable target for the treatment of hyperglycemia, it is not always suitable for the treatment of hyperphagia. In fact, independent regulation of glucose absorption and appetite requires a more complex approach for the treatment of metabolic diseases.

Bile deficiency induces changes in intestinal glucose absorption in mice

Surgery ◽  
2016 ◽  
Vol 160 (6) ◽  
pp. 1496-1507 ◽  
Author(s):  
Yehui Du ◽  
Hao Chen ◽  
Zefeng Xuan ◽  
Wenfeng Song ◽  
Liangjie Hong ◽  
...  
Keyword(s):  
Glucose Absorption ◽  
Intestinal Glucose Absorption

scholarly journals Correction: Inhibitory Effects of Hydroethanolic Leaf Extracts of Kalanchoe brasiliensis and Kalanchoe pinnata (Crassulaceae) against Local Effects Induced by Bothrops jararaca Snake Venom

PLoS ONE ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. e0172598 ◽  
Author(s):  
Júlia Morais Fernandes ◽  
Juliana Félix-Silva ◽  
Lorena Medeiros da Cunha ◽  
Jacyra Antunes dos Santos Gomes ◽  
Emerson Michell da Silva Siqueira ◽  
...  
Keyword(s):  
Snake Venom ◽  
Inhibitory Effects ◽  
Leaf Extracts ◽  
Local Effects ◽  
Bothrops Jararaca ◽  
Kalanchoe Pinnata

scholarly journals Potential of Syzygium polyanthum (Daun Salam) in Lowering Blood Glucose Level: A Review

2021 ◽  
Vol 29 (4) ◽  
Author(s):  
Nur Salsabeela Mohd Rahim ◽  
Ida Farah Ahmad ◽  
Terence Yew Chin Tan
Keyword(s):  
Blood Glucose ◽  
Scientific Evidence ◽  
Safety Evaluation ◽  
Underlying Mechanism ◽  
Glucose Absorption ◽  
Diabetic Patients ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Herbal Decoction ◽  
Intestinal Glucose Absorption

Syzygium polyanthum is a herb widely used in Malaysia and Indonesia in cuisines. Traditionally, the herbal decoction of S. polyanthum (daun salam) leaves is often used by diabetic patients in Indonesia. Therefore, our objective is to evaluate the scientific evidence available for S. polyanthum in lowering blood glucose levels (BGL). We systematically searched Pubmed, Google Scholar, Scopus, CENTRAL. LILAC and clinicaltrials.gov databases up to 23rd October 2020 using the keywords “Syzygium polyanthum” and “antidiabetic”. From the selected 413 articles, eight studies involving rodents were included. All results showed a significant effect in lowering BGL without any adverse effects. The possible underlying mechanism of action is attributed to inhibiting intestinal glucose absorption and enhancing glucose uptake by the muscles. Chemical families responsible for the effect were determined as flavonoids, alkaloids and terpenoids. Thus, S. polyanthum leaves showed potential antidiabetic properties, but further research is required to identify the active compounds followed by the safety evaluation of this compound.

scholarly journals Allelopathic effect of Azadirachta indica L. on the germination of Abelmoschus esculentus L.

2014 ◽  
Vol 15 ◽  
pp. 13-22 ◽  
Author(s):  
T. Vaithiyanathan ◽  
M. Soundari ◽  
M. Rajesh ◽  
K. Sankar Ganesh ◽  
P. Sundaramoorthy
Keyword(s):  
Azadirachta Indica ◽  
Photosynthetic Pigment ◽  
Research Work ◽  
Chemical Compounds ◽  
Abelmoschus Esculentus ◽  
Allelopathic Effect ◽  
Root Extract ◽  
Root Bark ◽  
Inhibitory Effects ◽  
Leaf Extracts

The chemical compounds have been reported to be exuded by plants and their inhibitory effects of other plants. The research work was carried out to study the allelopathic effect of root, bark and leaf extracts of Azadirachta indica L. on the seed germination of Abelmoschus esculentus L. Germination studies were conducted in laboratory, the bhendi seeds treated with the root, bark and leaf extracts of Neem. On the seventh day the morphological parameters, photosynthetic pigment and biochemical contents were analysed. The result showed that the rate of germination of bhendi decreased in all Azadirachta indica L. extracts. The reduction in biochemical contents of bhendi was also noted. The highest rate of germination was observed in control (distilled water) treatment and the highest rate of inhibition was observed in root extract followed by bark and leaf extracts.

Effects of stevioside, a natural sweetener, on intestinal glucose absorption in hamsters

1994 ◽  
Vol 14 (11) ◽  
pp. 1711-1720 ◽  
Author(s):  
Chaivat Toskulkao ◽  
Monthaporn Sutheerawattananon
Keyword(s):  
Glucose Absorption ◽  
Intestinal Glucose Absorption
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