scholarly journals Mechanisms of Glucose Absorption in the Small Intestine in Health and Metabolic Diseases and Their Role in Appetite Regulation

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2474
Author(s):  
Lyudmila V. Gromova ◽  
Serguei O. Fetissov ◽  
Andrey A. Gruzdkov
Keyword(s):  
Small Intestine ◽  
Blood Glucose ◽  
Metabolic Diseases ◽  
Glucose Absorption ◽  
Cellular Mechanisms ◽  
Physiological Conditions ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
New Strategy ◽  
Intestinal Glucose Absorption

The worldwide prevalence of metabolic diseases such as obesity, metabolic syndrome and type 2 diabetes shows an upward trend in recent decades. A characteristic feature of these diseases is hyperglycemia which can be associated with hyperphagia. Absorption of glucose in the small intestine physiologically contributes to the regulation of blood glucose levels, and hence, appears as a putative target for treatment of hyperglycemia. In fact, recent progress in understanding the molecular and cellular mechanisms of glucose absorption in the gut and its reabsorption in the kidney helped to develop a new strategy of diabetes treatment. Changes in blood glucose levels are also involved in regulation of appetite, suggesting that glucose absorption may be relevant to hyperphagia in metabolic diseases. In this review we discuss the mechanisms of glucose absorption in the small intestine in physiological conditions and their alterations in metabolic diseases as well as their relevance to the regulation of appetite. The key role of SGLT1 transporter in intestinal glucose absorption in both physiological conditions and in diabetes was clearly established. We conclude that although inhibition of small intestinal glucose absorption represents a valuable target for the treatment of hyperglycemia, it is not always suitable for the treatment of hyperphagia. In fact, independent regulation of glucose absorption and appetite requires a more complex approach for the treatment of metabolic diseases.

scholarly journals Multifaceted interplay among mediators and regulators of intestinal glucose absorption: potential impacts on diabetes research and treatment

2015 ◽  
Vol 309 (11) ◽  
pp. E887-E899 ◽  
Author(s):  
Leo Ka Yu Chan ◽  
Po Sing Leung
Keyword(s):  
Small Intestine ◽  
Blood Glucose ◽  
Critical Role ◽  
Glucose Absorption ◽  
Therapeutic Interventions ◽  
Diabetes Research ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Patients With Diabetes ◽  
Intestinal Glucose Absorption

Glucose is the prominent molecule that characterizes diabetes and, like the vast majority of nutrients in our diet, it is absorbed and enters the bloodstream directly through the small intestine; hence, small intestine physiology impacts blood glucose levels directly. Accordingly, intestinal regulatory modulators represent a promising avenue through which diabetic blood glucose levels might be moderated clinically. Despite the critical role of small intestine in blood glucose homeostasis, most physiological diabetes research has focused on other organs, such as the pancreas, kidney, and liver. We contend that an improved understanding of intestinal regulatory mediators may be fundamental for the development of first-line preventive and therapeutic interventions in patients with diabetes and diabetes-related diseases. This review summarizes the major important intestinal regulatory mediators, discusses how they influence intestinal glucose absorption, and suggests possible candidates for future diabetes research and the development of antidiabetic therapeutic agents.

scholarly journals Potential of Syzygium polyanthum (Daun Salam) in Lowering Blood Glucose Level: A Review

2021 ◽  
Vol 29 (4) ◽  
Author(s):  
Nur Salsabeela Mohd Rahim ◽  
Ida Farah Ahmad ◽  
Terence Yew Chin Tan
Keyword(s):  
Blood Glucose ◽  
Scientific Evidence ◽  
Safety Evaluation ◽  
Underlying Mechanism ◽  
Glucose Absorption ◽  
Diabetic Patients ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Herbal Decoction ◽  
Intestinal Glucose Absorption

Syzygium polyanthum is a herb widely used in Malaysia and Indonesia in cuisines. Traditionally, the herbal decoction of S. polyanthum (daun salam) leaves is often used by diabetic patients in Indonesia. Therefore, our objective is to evaluate the scientific evidence available for S. polyanthum in lowering blood glucose levels (BGL). We systematically searched Pubmed, Google Scholar, Scopus, CENTRAL. LILAC and clinicaltrials.gov databases up to 23rd October 2020 using the keywords “Syzygium polyanthum” and “antidiabetic”. From the selected 413 articles, eight studies involving rodents were included. All results showed a significant effect in lowering BGL without any adverse effects. The possible underlying mechanism of action is attributed to inhibiting intestinal glucose absorption and enhancing glucose uptake by the muscles. Chemical families responsible for the effect were determined as flavonoids, alkaloids and terpenoids. Thus, S. polyanthum leaves showed potential antidiabetic properties, but further research is required to identify the active compounds followed by the safety evaluation of this compound.

The beaver pond analogy of blood glucose control.

1999 ◽  
Vol 276 (6) ◽  
pp. S69 ◽  
Author(s):  
D P Swain
Keyword(s):  
Blood Glucose ◽  
Water Level ◽  
Blood Glucose Control ◽  
Glucose Absorption ◽  
Beaver Pond ◽  
Counterregulatory Hormones ◽  
Glucose Levels ◽  
Physiological Variables ◽  
Blood Glucose Levels ◽  
Stream Beds

The concentration of glucose is tightly regulated in the blood by a complicated set of physiological variables. To provide students with a means to more readily understand these complex mechanisms, the control of the water level in a beaver pond is presented as an analogy. A beaver must maintain a constant water level in the pond for the proper functioning of the lodge, just as blood glucose is maintained for, among other reasons, brain function. The beaver controls the water level by changing outflow over the dam and inflow from stream beds. Water flow over the dam is analogous to glucose leaving the blood for tissues, which is controlled by insulin. Inflow of water from streams is analogous to glucose absorption from the gastrointestinal tract and glucose release from the liver, the latter being controlled by glucagon and other counterregulatory hormones. The analogy is extended by considering the effects of exercise in normal and diabetic individuals on blood glucose levels.

scholarly journals Incidence of metabolic diseases of dairy cows in Puerto Rico and its relationship with production and reproduction behavior

1969 ◽  
Vol 92 (1-2) ◽  
pp. 39-52
Author(s):  
Julio C. Meléndez ◽  
José Pantoja ◽  
Angel A. Custodio ◽  
John Fernández Van Cleve ◽  
Raúl Macchiavelli ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Body Condition ◽  
Metabolic Disorders ◽  
Metabolic Diseases ◽  
Body Condition Score ◽  
Normal Blood ◽  
Blood Calcium ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Condition Score

Data were obtained from 89 Holstein cows, distributed among seven commercial herds, to evaluate the incidence of metabolic disorders during the periparturient transition period. The herds were enrolled in the Dairy Herd Improvement Program (DHIP) and were routinely visited by veterinarians, who diagnosed any metabolic disorders. The cows were observed every two weeks to evaluate body condition score (1 to 5 scale), to discern clinical disorders and to obtain blood samples for chemical analyses. Clinical metabolic diseases were not diagnosed, but 34% of the cows showed sub-clinical hypocalcaemia (blood calcium less than 7.9 mg/dl) and 14% had blood glucose levels less than 39.9 mg/dl. Although not significant (P greater than 0.05), milk production was higher at the second and third milk weighings in the normal cows than in those with sub-clinical hypocalcaemia (27.5 and 25.6 vs. 25.1 and 23.6 kg, respectively). The interval between parturition and first service was shorter in cows with normal blood calcium levels than in those that suffered sub-clinical hypocalcaemia (74 vs. 91 days, P less than 0.05). Mean body condition score of the cows without sub-clinical hypocalcaemia or sub-normal blood glucose levels was higher than that of cows with these conditions (2.5 vs. 2.3 in both criteria, P less than 0.05). It is concluded that postpartum blood calcium concentrations affect the interval from parturition to first service and that the probability of occurrence of hypocalcaemia after parturition can be estimated from prepartum blood calcium concentrations.

scholarly journals Uji Efektivitas Beras Herbal Forte terhadap Penurunan Kadar Glukosa Darah Pasien Diabetes Melitus Tipe 2 (Study of the Herbal Rice Forte Effectiveness on Decreasing Blood Glucose of Diabetes Mellitus Type 2 Patient)

2018 ◽  
Vol 6 (1) ◽  
pp. 85
Author(s):  
Gema Akbar Wakhidana ◽  
Ancah Caesarina Novi Marchianti ◽  
Ali Santosa
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Treatment Group ◽  
Metabolic Diseases ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Type 2 Dm

Diabetes mellitus is metabolic diseases characterized by hyperglycemia caused by disturbances in insulin secretion or insulin activity. Herbal Forte Rice is rice synthetic material composed of main purple sweet potato and corn flour. It contains antioksidan, fiber, resistant starch and having moderate glycemic index. This study aimed to determine the effectivity of Herbal Forte Rice on decreasing blood glucose levels of patients type 2 DM. It used a cross-over design, the role of research subjects was both as control and treatment groups. Total sample of this research consisted of 60 samples. The treatment group was given Herbal Forte Rice for 7 days in 2 consecutive meals, while the control group did not receive any intervention. The results showed the average level of Fasting Blood Glucose (FBG) beginning and end of the treatment group 179.76 mg/dL and 138.7 mg/dL; FBG beginning and end of the control 180.87 mg/dL and 187.63 mg/dL; 2 hours post prandial Blood Glucose (2hppBG) levels of beginning and end of the treatment group 284.37 mg/dL and 183.8 mg/dL; 2hppBG levels beginning and end of the control 280.57 mg/dL and 284.13 mg/dL. This study concludes that Herbal Forte Rice effective on decreasing blood glucose levels of patients type 2 DM.   Keywords: diabetes mellitus, Rice Herbal Forte, GDP and GD2PP  

scholarly journals The Contents of Phenol and Flavonoid Compounds in Water Extract of Gyrinops Versteegii Leaves Have Potentially as Natural Antioxidants and Hypoglicemic in Hyperglycemic Wistar Rats

2018 ◽  
Vol 11 (3) ◽  
pp. 1543-1552
Author(s):  
Adi Parwata ◽  
Laksmiwati Sudiarta ◽  
M. N. Dina ◽  
Sutirta Yasa
Keyword(s):  
Blood Glucose ◽  
Wistar Rats ◽  
Cell Damage ◽  
Water Extract ◽  
Natural Antioxidants ◽  
Glucose Absorption ◽  
Glucose Content ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Reduce Blood Glucose

Phenols and flavonoids compounds in their activities as antioxidants can reduce blood glucose levels (hypoglycemic) through a mechanism to inhibit cell damage at pancreatic Langerhans gland, inhibit glucose absorption in the intestine and cell resistance to insulin. Preliminary analysis shows that total phenol and flavonoid contens is 2099,5025 mg GAE / 100 g, and 8133,322 mg QE / 100 gram, Antioxidant capacity with IC50 = 12.58 mg / mL. LD50 = 6,355,3536 gram. This results revealad that the water extract of Gyrinops versteegii leaves can be developed as an alternative to natural antioxidant, safe for consumption and can reduce blood glucose in hyperglycemic Wistar rats. The results of the measurement of the effect of decreasing blood glucose content showed that the water extract of Gyrinops versteegii leaves at doses of 100, 200 and 400 mg / kgBW significantly (p <0.01) could reduce blood glucose contents in hyperglycemic Wistar rats. The activity of reducing blood glucose levels (hypoglycemic) with oral doses of water extract of Gyrinops versteegii leaves was 100,200 and 400 mg / kgBW was 53.6% (53.6 ± 5.8), 58.9% (58.9 ± 8.6 ) and 75.8% (75.8 ± 1.3). High contents of phenol and flavonoids allegedly a factor that causes water extract of Gyrinops versteegii leaves to reduce blood glucose levels in hyperglycemic Wistar rats.

scholarly journals Reductive Effect of Acitretin on Blood Glucose Levels in Chinese Patients With Psoriasis

2021 ◽  
Vol 8 ◽  
Author(s):  
Hua Qian ◽  
Yehong Kuang ◽  
Juan Su ◽  
Menglin Chen ◽  
Xiang Chen ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Hepg2 Cells ◽  
Metabolic Diseases ◽  
Low Cost ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Chinese Patients ◽  
Control Group ◽  
Glucose Levels ◽  
Blood Glucose Levels

Background: Psoriasis is a skin condition associated with increased risks of developing metabolic diseases, such as diabetes and hyperlipidaemia. Retinoid drugs, including acitretin, are commonly used to treat psoriasis due to its low cost and tolerable side effects.Objective: This study aimed to explore the influence of acitretin on patients' metabolism levels, especially lipid and glucose.Methods: In this retrospective study, a total of 685 psoriatic patients and 395 age/sex matched controls were enrolled. The demographic and biochemical indexes of each participant were recorded. Acitretin (30 mg/d) combined with the topical ointment calcipotriol was used to treat the psoriatic patients, and the glucose and lipid profiles of patients before and after acitretin treatment were analyzed.Results: The blood glucose levels of 685 psoriasis patients were significantly higher than that of the control group (P &lt; 0.001), while the blood lipid levels showed no difference between psoriatic patients and the matched controls. Triglyceride and low-density lipoprotein levels were significantly increased in 247 patients (P &lt; 0.05) after 8 weeks of treatment with acitretin. Interestingly, there was a remarkable downward trend in body mass index (BMI) and blood glucose levels (P &lt; 0.05) after acitretin treatment. Additionally, expression of both GLUT1 and GLUT4 in HaCaT and HepG2 cells were significantly increased when treated with acitretin. Compared to acitretin-free cells, the uptake of 2-NBDG was significantly higher in HaCaT and HepG2 cells after incubation with 5000 ng/mL acitretin for 36 h.Conclusion: Acitretin plays a significant role of reducing the blood glucose level in psoriasis patients. The mechanism of lowering blood glucose may be through increasing glucose intake by cells, thereby reducing glucose levels in the peripheral blood.

scholarly journals Does guar gum improve post-prandial hyperglycaemia in humans by reducing small intestinal contact area?

1984 ◽  
Vol 52 (2) ◽  
pp. 197-204 ◽  
Author(s):  
N. A. Blackburn ◽  
A. M. Holgate ◽  
N. W. Read
Keyword(s):  
Small Intestine ◽  
Blood Glucose ◽  
Gastric Emptying ◽  
Contact Area ◽  
Guar Gum ◽  
Healthy Human ◽  
Glucose Response ◽  
Intestinal Tube ◽  
Glucose Levels ◽  
Blood Glucose Levels

1. The possibility that viscous polysaccharides, such as guar gum, could lower post-prandial blood glucose levels in part by restricting carbohydrate solutions to a smaller area of small intestine was investigated in twenty healthy human volunteers.2. Addition of guar gum (22.5 g/l) delayed the mouth-to-caecum transit time of a hypotonic lactulose drink, but did not affect gastric emptying.3. When a 250 ml solution containing 50 g glucose was confined to a 550 mm length of intestine by an occluding balloon attached to an intestinal tube, maximum blood glucose response was significantly reduced (P < 0.05) though only by 0.9 mmol/l.4. Addition of guar gum (36 g/l) had no effect on the distribution of a radio-labelled glucose drink (250 ml; 200 g glucose/l) in the small intestine, monitored using a gamma camera, although it significantly delayed gastric emptying (t½ (min): guar gum v. control 115 (SE 15) v. 73 (SE 8)).5. Reduced contact area is unlikely to be one of the mechanisms by which guar gum improves glucose tolerance.

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