Protein unbound pharmacokinetics of ambroxol in the blood and brains of rats and the interaction of ambroxol with Polygala tenuifolia by multiple microdialysis

2021 ◽  
Vol 269 ◽  
pp. 113764
Author(s):  
Chao-Nan Yang ◽  
Wen-Ya Peng ◽  
Lie-Chwen Lin ◽  
Tung-Hu Tsai
Keyword(s):  
Polygala Tenuifolia

scholarly journals Effect of Polygala tenuifolia Root Extract on Scopolamine-Induced Impairment of Rat Spatial Cognition in an Eight-Arm Radial Maze Task

2007 ◽  
Vol 30 (9) ◽  
pp. 1727-1731 ◽  
Author(s):  
Xiu-Lan Sun ◽  
Hideyuki Ito ◽  
Takayoshi Masuoka ◽  
Chiaki Kamei ◽  
Tsutomu Hatano
Keyword(s):  
Spatial Cognition ◽  
Radial Maze ◽  
Root Extract ◽  
Maze Task ◽  
Polygala Tenuifolia ◽  
Radial Maze Task

Norepinephrine transporter inhibitors from Polygala tenuifolia

2020 ◽  
Vol 16 (3) ◽  
Author(s):  
Y.-L. Lin ◽  
W.-P. Chen ◽  
H.-C. Ko ◽  
F.-N. Ko ◽  
T.-S. Wu
Keyword(s):  
Norepinephrine Transporter ◽  
Polygala Tenuifolia

scholarly journals The Chinese Herbal Formula PAPZ Ameliorates Behavioral Abnormalities in Depressive Mice

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 859 ◽  
Author(s):  
Huiling Chen ◽  
Qing Huang ◽  
Shunjia Zhang ◽  
Kaiqiang Hu ◽  
Wenxiang Xiong ◽  
...  
Keyword(s):  
Protein Expression ◽  
Therapeutic Effects ◽  
Herbal Formula ◽  
Chinese Herbal Formula ◽  
Chinese Herbal ◽  
Hippocampal Tissue ◽  
Behavioral Abnormalities ◽  
Antidepressant Effects ◽  
Polygala Tenuifolia ◽  
History Of

Major depressive disorder (MDD) is a chronic mental disorder characterized by mixed symptoms and complex pathogenesis. With long history of practical application, traditional Chinese medicine (TCM) offers many herbs for the treatment and rehabilitation of chronic disease. In this study, we developed a modified Chinese herbal formula using Panax ginseng, Angelica Sinensis, Polygala tenuifolia Willd, and Ziziphi spinosae Semen (PAPZ), based on an ancient TCM prescription. The antidepressant effects of PAPZ were investigated with a corticosterone (CORT) model of depression in mice. Our results showed that administration of PAPZ ameliorated depression-like phenotypes in the CORT model. An anatomic study showed that chronic PAPZ administration upregulated the protein expression of brain-derived neurotrophic factor (BDNF) in hippocampal tissue. The enzyme activity of superoxide dismutase was enhanced in hippocampal tissue, in line with a decreased malondialdehyde level. Taken together, these findings suggested that PAPZ has therapeutic effects in a mice depression model through increasing protein expression of BDNF and improving the anti-oxidation ability of the brain.

Sign in / Sign up

Export Citation Format

Share Document