Gut microbiota affects the efficacy of Danggui Buxue Tang by affecting plasma concentration of active ingredients

BC® powder (I) is a commercially available analgesic containing the active ingredients aspirin and salicylamide. The kinetics of I, BC® powder minus aspirin (II), and BC® powder minus salicylamide (III) were evaluated in 13 volunteers. Ten minutes after administration of I, aspirin reached a maximum concentration of 12.9 μg/mL, while salicylamide concentration reached a peak value of 3.4 μg/mL. However, when III was administered, aspirin was not detected at 10 min and only reached a concentration of 0.4 μg/mL at 2 and 6 h. Furthermore, the area under the plasma concentration versus time curve for aspirin when III was administered was sixfold less compared with treatment with I. The area under the curve for aspirin metabolites was significantly different in I versus III. After treatment with II, a delay in salicylamide peak concentration was observed. Gentisamide was not detected throughout the study. This study demonstrates that salicylamide significantly enhances plasma levels of aspirin with potential therapeutic implications.Key words: aspirin, BC® powder, bioavailability, salicylamide.

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Bifidobacterium breve MCC1274 with glycosidic activity enhances in vivo isoflavone bioavailability

Beneficial Microbes ◽

10.3920/bm2018.0179 ◽

2019 ◽

Vol 10 (5) ◽

pp. 521-531 ◽

Cited By ~ 1

Author(s):

R. Yao ◽

C.B. Wong ◽

K. Nakamura ◽

E. Mitsuyama ◽

A. Tanaka ◽

...

Keyword(s):

Plasma Concentration ◽

Gut Microbiota ◽

Oral Administration ◽

Kinetic Analysis ◽

Intestinal Absorption ◽

Relative Abundance ◽

Intestinal Metabolism ◽

Control Groups ◽

Bifidobacterium Breve

Polyphenols are plant derived compounds that exert many beneficial health effects to the human host. However, associated health benefits of dietary polyphenol are highly dependent on their intestinal metabolism, bioavailability, and absorption. Bifidobacteria, which represent the key members of gut microbiota, have been suggested to promote gut microbial homeostasis and may be involved in the metabolism of polyphenols. In this study, the capabilities of thirteen Bifidobacterium strains in hydrolysing polyphenol glycosides were evaluated. Among the tested strains, Bifidobacterium breve MCC1274 was found to possess the highest β-glucosidase activity and strong capability to convert daidzin and trans-polydatin to their aglycones; while kinetic analysis revealed that B. breve MCC1274 hydrolysed more than 50% of daidzin and trans-polydatin at less than 3 h of incubation. Further investigation using rats with an antibiotics-disturbed microbiome revealed that following the ingestion of daidzin glycoside, oral administration of B. breve MCC1274 significantly enhanced the plasma concentration of daidzein in rats pre-treated with antibiotics as compared to antibiotics-pre-treated control and non-treated control groups. The relative abundance of Actinobacteria and the total numbers of B. breve were also significantly higher in antibiotics-pre-treated rats administered with B. breve MCC1274 than that of the control groups. These findings suggest that B. breve MCC1274 is effective in enhancing the bioavailability of daidzein in the gut under dysbiosis conditions and may potentially improve intestinal absorption of isoflavones and promote human health.

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Flavonoids from Rosa davurica Pall. fruits prevent high-fat diet-induced obesity and liver injury via modulation of gut microbiota in mice

Food & Function ◽

10.1039/d1fo01373d ◽

2021 ◽

Author(s):

Chun-Yan Shen ◽

Yun-Fang Hao ◽

Zhan-Xi Hao ◽

Qiang Liu ◽

Lu Zhang ◽

...

Keyword(s):

Liver Injury ◽

Gut Microbiota ◽

High Fat Diet ◽

Healthy Food ◽

High Fat ◽

Active Ingredients ◽

Diet Induced Obesity

Rosa davurica Pall. (RDP) fruits are popularly consumed as beverages and healthy food in China because of their various beneficial activities. Especially, flavonoids are one of the major active ingredients...

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