Exploring the antifungal activity and mechanism of action of Zingiberaceae rhizome extracts against Malassezia furfur

2021 ◽  
Vol 279 ◽  
pp. 114354
Author(s):  
Natthavadh Laokor ◽  
Weerapong Juntachai
2016 ◽  
Vol 5 (11) ◽  
pp. 5047 ◽  
Author(s):  
Mamatha Pingili* ◽  
Sridhar Vanga ◽  
Rama Krishna Raparla

In the present study, an attempt was made to know the activity of different plant extracts against the dandruff causing organism Malassezia furfur. Various parts of twelve different plants were collected and their crude as well as powered extracts were used for the activity studies. The evaluation was done using cup plate method. Sensitivity of the organism to marketed antidandruff shampoos was also studied. Of all the extracts, antifungal activity was shown by lemon, amla, shikakai, henna (decreasing order of activity). These results were compared with the antifungal activity of three branded shampoos. On comparison, it is inferred that plant extracts showed promising activity against Malassezia furfur when compared with the marketed antidandruff shampoos. 


Steroids ◽  
2011 ◽  
Vol 76 (10-11) ◽  
pp. 1069-1081 ◽  
Author(s):  
Gonzalo Visbal ◽  
Gioconda San-Blas ◽  
Alexis Maldonado ◽  
Álvaro Álvarez-Aular ◽  
Mario V. Capparelli ◽  
...  

2020 ◽  
Vol 3 (2) ◽  
pp. 76-81
Author(s):  
Rini Lestari

Red galangal (Alpinia purpurata) is a plant that belongs to the Zingiberaceae family. Red galangal rhizome is traditionally used to treat phlegm and ringworm. Red galangal rhizome contains secondary metabolites of essential oils, eugnol, sesquiterpenes, pinen, kaemferida, galanagn and galangol which have anti-fungal properties. This study aims to determine the antifungal activity of red galangal rhizome ethanol extract against Malasezia furfur and Microsporum canis using agar diffusion method. Red galangal extract is made with a concentration variation of 2%, 5% and 10%. The results showed the antifungal activity of red galangal ethanol extract in the form of inhibiting diameters at an average concentration of 2%, 5% and 10% against Malasezia furfur was 16.77 mm, 17.91 mm and 19.72 mm. The average inhibitory diameter of Microsporum canis is 10.58 mm, 13.57 mm and 14.51 mm. Based on the results of this study it can be concluded that the ethanol extract of red galangal has antifungal activity against Malasezia furfur and Microsporum canis.


2018 ◽  
Vol 5 (2) ◽  
pp. 62
Author(s):  
Anna L Yusuf ◽  
Ecin Nurawaliah ◽  
Nurhidayati Harun

<p align="center"><strong>Abstrak</strong></p><p align="center"><strong> </strong></p><p>Kandungan daun kelor (<em>Moringa oleifera</em> L) diketahui dapat berkhasiat sebagai antijamur. Penelitian ini bertujuan untuk memformulasi dan mengetahui aktivitas antijamur gel yang mengandung daun kelor terhadap jamur <em>Malasezia furfur</em>. Ekstraksi daun kelor dilakukan menggunakan etanol 70% dengan metode maserasi. Formulasi gel yang mengandung ekstrak etanol daun kelor dilakukan menggunakan hidroksi propil metil selulosa (HPMC) dengan berbagai konsentrasi, yaitu 2, 3, dan 4%., Evaluasi gel yang dilakukan adalah uji organoleptik, homogenitas, pH, daya sebar, daya lekat, dan viskositas. Kemudian dilakukan uji aktivitas antijamur dengan menggunakan metode difusi padat dengan kertas cakram, dan digunakan gel ketokonazol sebagai pembanding. Parameter yang diukur adalah zona hambat antijamur. Hasil kemudian dianalisis statistik <em>Kruskall Wallis</em> dan <em>Mann Withney</em>. Berdasarkan evaluasi gel, diperoleh bahwa peningkatan  konsentrasi basis HPMC 2, 3, dan 4% dalam sediaan gel  ekstrak etanol daun kelor dapat meningkatkan viskositas gel, daya lekat gel, menyebabkan penurunan daya sebar gel, dan mempengaruhi peningkatan konsistensi sediaan gelpada uji organoleptik tanpa mempengaruhi uji pH gel dan homogenitas gel. Formula yang memiliki sifat fisik gel yang yang baik jika dilihat dari hasil  uji sifat fisik gel yang meliputi uji organoleptik,homogenitas, pH, daya sebar daya lekat dan viskositas   yaitu formula  gel ekstrak etanol daun kelor dengan konsentrasi basis HPMC 2 % karena hampir dari semua uji memenuhi persyaratan literatur. Dari penelitian ini dapat disimpulkan  gel ekstrak etanol daun kelor mempunyai aktivitas antijamur <em>M.furfur</em> dan gel yang mengandung HPMC 2% memiliki sifat fisik gel dan aktivitas antijamur lebih baik jika dibandingkan dengan gel konsentrasi HPMC 3 dan 4%.</p><p> </p><p><strong>Kata Kunci:</strong> Daun Kelor, <em>Moringa </em><em>o</em><em>leifera L,</em> gel, antijamur, <em>Malassezia </em><em>f</em><em>urfur.</em></p><p><em> </em></p><p><em> </em></p><p align="center"><strong><em>The effectiveness test of gel of ethanol extract of Moringa oleifera leaves <br /> as antifungal of </em></strong><strong><em>Malassezia furfur</em></strong></p><p align="center"><strong><em> </em></strong></p><p align="center"><strong><em>Abstract</em></strong><strong><em></em></strong></p><p><strong><em> </em></strong></p><p><em>Moringa leaf content (Moringa oleifera L) is known to be efficacious as an antifungal. The aim of this research is to formulate and to know gel antifungal activity containing moringa leaf against Malasezia furfur fungus. Moringa leaf extraction was done using 70% ethanol by maceration method. The gel formulation containing ethanol extract of </em><em>moringa </em><em>was conducted using hydroxy propyl methyl cellulose (HPMC) with various concentrations, ie 2, 3, and 4%. Evaluation of gel performed was organoleptic, homogeneity, pH, spreading, </em><em>and </em><em>viscosity. Then the antifungal activity </em><em>was </em><em>tested using solid diffusion method with paper disc, and used ketoconazole gel as comparison. The measured parameter </em><em>wa</em><em>s the antifungal block zone. The results were then analyzed statistically </em><em>using </em><em>Kruskall Wallis and Mann Withney. Based on the gel evaluation, it was found that the increased concentrations of HPMC 2, 3, and 4% base concentrations in the gel preparation of ethanol extract of moringa leaf can increase gel viscosity, gel adhesiveness, decrease the gel power, and influence the consistency of preparation for organoleptic test without affecting the test pH gel and gel homogeneity. Formula which have good physical properties of gel when viewed from the test results of physical properties of gel which include organoleptic test, homogeneity, pH, viscosity sticky power and viscosity is gel gel ethanol extract leaf kelor with 2% HPMC base concentration because almost of all test meet the literature requirements. From this study, it can be concluded that leaf extract gel ethanol gel has antifungal activity of M.furfur and gel containing HPMC 2% has gel physical properties and antifungal activity is better when compared with HPMC 3 and 4% concentration gel</em><em></em></p><p><em> </em></p><p><strong><em>Keywords</em></strong><em>: </em><em> </em><em>Moringa olifera L.,</em><em>gel, </em><em> antifungal</em><em>, </em><em>Malasezia furfur</em><em></em></p>


Chemotherapy ◽  
1998 ◽  
Vol 44 (2) ◽  
pp. 112-120 ◽  
Author(s):  
Hidehiko Yamada ◽  
Toshihiko Tsuda ◽  
Taiji Watanabe ◽  
Satoshi Kusakabe ◽  
Hidenori Mochizuki

2009 ◽  
Vol 24 (5) ◽  
pp. 715-719 ◽  
Author(s):  
Rosana Filip ◽  
Roberto Davicino ◽  
Claudia Anesini

2019 ◽  
Vol 107 ◽  
pp. 46-50 ◽  
Author(s):  
Congyi Zhu ◽  
Mengying Lei ◽  
Mebeaselassie Andargie ◽  
Jiwu Zeng ◽  
Jianxiong Li

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