scholarly journals Mesoporous carbon nanomaterials induced pulmonary surfactant inhibition, cytotoxicity, inflammation and lung fibrosis

2017 ◽  
Vol 62 ◽  
pp. 100-114 ◽  
Author(s):  
Yunan Chen ◽  
Yi Yang ◽  
Bolong Xu ◽  
Shunhao Wang ◽  
Bin Li ◽  
...  
Keyword(s):  
Lung Fibrosis ◽  
Mesoporous Carbon ◽  
Pulmonary Surfactant ◽  
Carbon Nanomaterials ◽  
Surfactant Inhibition

Interaction of Particles with the Pulmonary Interface: Effects on Surface Elasticity

2014 ◽  
Vol 658 ◽  
pp. 459-464
Author(s):  
Bogdan Munteanu ◽  
Yves Berthier ◽  
Jean Paul Rieu ◽  
Ana Maria Trunfio-Sfarghiu
Keyword(s):  
Pulmonary Surfactant ◽  
Adhesion Force ◽  
Surface Elasticity ◽  
Lipid Monolayer ◽  
Langmuir Trough ◽  
Severe Respiratory Distress ◽  
Supported Lipid Bilayer ◽  
Atomic Force ◽  
Surfactant Inhibition ◽  
Interface Effects

We present an experimental study of the interactions of negative and positive model particles and their influence on the surface elasticity of biomimetic pulmonary surfactant. In this purpose we have measured the adhesion force between negative (G) and positive (GS) particles and supported lipid bilayer by Atomic Force Spectroscopy. In addition, the modification in surface elasticity of lipid monolayer under quasistatic compression when interacting with negative and positive particles was investigated on a Langmuir trough. We found that, positive particles interact poorly with biomimetic pulmonary surfactant, therefore no modifications in surface elasticity were observed. Conversely, negative charged particles interact strongly with the biomimetic pulmonary surfactant, decreasing the surface elasticity. The results are directly relevant for understanding the interactions and the effects of particulate matter on pulmonary structures which could lead to pulmonary surfactant inhibition or deficiency causing severe respiratory distress or pathologies.

Mesoporous carbon nanomaterials with tunable geometries and porous structures fabricated by a surface-induced assembly strategy

2021 ◽  
Vol 35 ◽  
pp. 602-609
Author(s):  
Shuibin Tu ◽  
Hai Su ◽  
Dong Sui ◽  
Yongwu He ◽  
Mingren Cheng ◽  
...  
Keyword(s):  
Mesoporous Carbon ◽  
Carbon Nanomaterials ◽  
Porous Structures ◽  
Assembly Strategy

scholarly journals Alveolar Type II cell transplantation restores pulmonary surfactant protein levels in lung fibrosis

2014 ◽  
Vol 33 (7) ◽  
pp. 758-765 ◽  
Author(s):  
Raquel Guillamat-Prats ◽  
Gemma Gay-Jordi ◽  
Antoni Xaubet ◽  
Victor I. Peinado ◽  
Anna Serrano-Mollar
Keyword(s):  
Cell Transplantation ◽  
Lung Fibrosis ◽  
Pulmonary Surfactant ◽  
Surfactant Protein ◽  
Alveolar Type ◽  
Type Ii ◽  
Protein Levels ◽  
Alveolar Type Ii Cell ◽  
Type Ii Cell ◽  
Pulmonary Surfactant Protein

Fe–N-doped hierarchical mesoporous carbon nanomaterials as efficient catalysts for oxygen reduction in both acidic and alkaline media

2019 ◽  
Vol 7 (20) ◽  
pp. 12518-12525 ◽  
Author(s):  
Rongmin Dun ◽  
Menggeng Hao ◽  
Yumiao Su ◽  
Wenmu Li
Keyword(s):  
Oxygen Reduction ◽  
Mesoporous Carbon ◽  
Carbon Nanomaterials ◽  
Catalytic Performance ◽  
Hollow Microspheres ◽  
Alkaline Media ◽  
Acidic And Alkaline Media

Hierarchical mesoporous carbon nanomaterials synthesized using Fe2O3 hollow microspheres as a multifunctional template exhibit efficient catalytic performance for oxygen reduction in both acidic and alkaline media.

scholarly journals Bio/Carbon Nanomaterials-The Adsorption of Lysozyme on Mesoporous Carbon Molecular Sieves-

2004 ◽  
Vol 61 (12) ◽  
pp. 623-627 ◽  
Author(s):  
Masahiko MIYAHARA ◽  
Ajayan VINU ◽  
Takashi NAKANISHI ◽  
Katsuhiko ARIGA
Keyword(s):  
Molecular Sieves ◽  
Mesoporous Carbon ◽  
Carbon Nanomaterials ◽  
Carbon Molecular Sieves

New approach to the treatment of bleomycin-induced lung fibrosis using pulmonary surfactant as pirfenidone carrier into the lung

2015 ◽  
Author(s):  
Carolin Laukamp ◽  
Alberto Hidalgo ◽  
Antonio Cruz ◽  
Jesus Perez-Gil ◽  
Matthias Ochs ◽  
...  
Keyword(s):  
Lung Fibrosis ◽  
Pulmonary Surfactant ◽  
New Approach

Aptamer-anchored di-polymer shell-capped mesoporous carbon as a drug carrier for bi-trigger targeted drug delivery

2017 ◽  
Vol 5 (33) ◽  
pp. 6882-6889 ◽  
Author(s):  
Yang Zhang ◽  
Yan-Qin Chang ◽  
Lu Han ◽  
Yue Zhang ◽  
Ming-Li Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Targeted Drug Delivery ◽  
Mesoporous Carbon ◽  
Carbon Nanomaterials ◽  
Drug Carrier ◽  
Polymer Shell ◽  
Targeted Drug

Mesoporous carbon nanomaterials have found applications in drug delivery and cancer therapy.

Interactions between plasma proteins and pulmonary surfactant: pulsating bubble studies

1989 ◽  
Vol 67 (6) ◽  
pp. 663-668 ◽  
Author(s):  
Kevin M. W. Keough ◽  
Caroline S. Parsons ◽  
Martin G. Tweeddale
Keyword(s):  
Surface Tension ◽  
Plasma Proteins ◽  
Pulmonary Surfactant ◽  
Distress Syndrome ◽  
Adsorption Process ◽  
Human Albumin ◽  
Water Interface ◽  
Dipalmitoyl Phosphatidylcholine ◽  
Air Water Interface ◽  
Surfactant Inhibition

The influence of human albumin, α-globulin, and fibrinogen on the actions of porcine pulmonary surfactant in a pulsating bubble surfactometer has been investigated. All three proteins detracted from the ability of the surfactant to adsorb to the air–water interface. The proteins also reduced the ability of surfactant to lower the opening pressures of bubbles cycling between different sizes in suspensions of surfactant. This was equivalent to restricting the ability of the surfactant to achieve low surface tension during compression of the surface. Of the three proteins, globulin competed most effectively with surfactant during the adsorption process, and albumin competed the least effectively. The proteins also may have interfered with the processes of surface refinement, which usually yields a monolayer enriched enough in dipalmitoyl phosphatidylcholine to achieve very low surface tension (very low opening pressures in the bubbles). Of the three proteins tested, albumin was least deleterious to surface refining whereas globulin and fibrinogen appeared to be about equally detrimental to the process.Key words: pulmonary surfactant, surface tension, adsorption, adult respiratory distress syndrome, surfactant inhibition.

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