Dietary New Zealand propolis supplementation reduced proinflammatory cytokines in an acute mouse model of air pollution exposure, without impacting on immune cell infiltration or lung function

AbstractExogenous electric fields are currently used in human therapy in a number of contexts. Interestingly, electric fields have also been shown to alter migration and function of immune cells, suggesting the potential for electric field-based immune therapy. Little is known as to the effect of electric field treatment (EFT) on the lung. To determine if EFT associates with changes in lung immune cell infiltration, we used a mouse model with varying methods of EFT application and measured cells and soluble mediators using flow cytometry and cytokine/chemokine multiplex. EFT was associated with a transient increase in lung neutrophils and decrease in eosinophils in naïve mice within 2 h of treatment, accompanied by an increase in IL-6 levels. In order to test whether EFT could alter eosinophil/neutrophil recruitment in a relevant disease model, a mouse model of allergic airway inflammation was used. Four EFT doses in allergen-sensitized mice resulted in increased neutrophil and reduced eosinophil infiltrates following allergen challenge, suggesting a durable change in inflammation by EFT. Mice with allergic inflammation were analyzed by flexiVent for measures of lung function. EFT-treated mice had increased inspiratory capacity and other measures of lung function were not diminished. These data suggest EFT may be used to manipulate immune cell infiltration in the lung without affecting lung function.

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Mesenchymal Stem Cells (MSCs) Attenuate Cutaneous Sclerodermatous Graft-Versus-Host Disease (Scl-GVHD) through Inhibition of Immune Cell Infiltration in a Mouse Model

Journal of Investigative Dermatology ◽

10.1016/j.jid.2017.02.986 ◽

2017 ◽

Vol 137 (9) ◽

pp. 1895-1904 ◽

Cited By ~ 15

Author(s):

Ji-Young Lim ◽

Da-Bin Ryu ◽

Sung-Eun Lee ◽

Gyeongsin Park ◽

Chang-Ki Min

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Mouse Model ◽

Graft Versus Host Disease ◽

Immune Cell ◽

Cell Infiltration ◽

Immune Cell Infiltration ◽

Host Disease ◽

Graft Versus Host

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Association between lung function of school age children and short-term exposure to air pollution and pollen: the PARIS cohort

Thorax ◽

10.1136/thoraxjnl-2020-215515 ◽

2021 ◽

pp. thoraxjnl-2020-215515

Author(s):

Hélène Amazouz ◽

Nicolas Bougas ◽

Michel Thibaudon ◽

Guillaume Lezmi ◽

Nicole Beydon ◽

...

Keyword(s):

Air Pollution ◽

Lung Function ◽

School Age Children ◽

School Age ◽

Short Term ◽

Short Term Exposure ◽

Air Pollution Exposure ◽

Total Pollen ◽

Pollution Exposure ◽

Cluster 2

BackgroundDaily levels of ambient air pollution and pollen may affect lung function but have rarely been studied together. We investigated short-term exposure to pollen and air pollution in relation to lung function in school-age children from a French population-based birth cohort.MethodsThis study included 1063 children from the PARIS (Pollution and Asthma Risk: an Infant Study) cohort whose lung function and FeNO measurements were performed at age 8 years old. Exposure data were collected up to 4 days before testing. We estimated daily total pollen concentration, daily allergenic risk indices for nine pollen taxa, as well as daily concentrations of three air pollutants (particulate matter less than 10 µm (PM10), nitrogen dioxide (NO2), ozone (O3)). Children with similar pollen and air pollution exposure were grouped using multidimensional longitudinal cluster analysis. Associations between clusters of pollen and air pollution exposure and respiratory indices (FEV1, FVC, FeNO) were studied using multivariable linear and logistic regression models adjusted for potential confounders.ResultsFour clusters of exposure were identified: no pollen and low air pollution (Cluster 1), grass pollen (Cluster 2), PM10 (Cluster 3) and birch/plane-tree pollen with high total pollen count (Cluster 4). Compared with children in Cluster 1, children in Cluster 2 had significantly lower FEV1 and FVC levels, and children from Cluster 3 had higher FeNO levels. For FEV1 and FVC, the associations appeared stronger in children with current asthma. Additional analysis suggested a joint effect of grass pollen and air pollution on lung function.ConclusionDaily ambient chemical and biological air quality could adversely influence lung function in children.

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Short-term ambient particulate air pollution exposure, microRNAs, blood pressure and lung function

Environmental Pollution ◽

10.1016/j.envpol.2021.118387 ◽

2021 ◽

pp. 118387

Author(s):

Xiaowei Cong ◽

Juan Zhang ◽

Rongli Sun ◽

Yuepu Pu

Keyword(s):

Blood Pressure ◽

Air Pollution ◽

Lung Function ◽

Short Term ◽

Particulate Air Pollution ◽

Air Pollution Exposure ◽

Pollution Exposure

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Effects of personal air pollution exposure on asthma symptoms, lung function and airway inflammation

Clinical & Experimental Allergy ◽

10.1111/cea.13130 ◽

2018 ◽

Vol 48 (7) ◽

pp. 798-805 ◽

Cited By ~ 14

Author(s):

L. Chambers ◽

J. Finch ◽

K. Edwards ◽

A. Jeanjean ◽

R. Leigh ◽

...

Keyword(s):

Air Pollution ◽

Lung Function ◽

Airway Inflammation ◽

Asthma Symptoms ◽

Air Pollution Exposure ◽

Pollution Exposure

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Air Pollution Exposure and Lung Function Until Age 16 Years: The PIAMA Birth Cohort Study

PEDIATRICS ◽

10.1542/peds.2019-2461o ◽

2019 ◽

Vol 144 (Supplement 1) ◽

pp. S11.2-S12

Author(s):

Kirsten M. Kloepfer

Keyword(s):

Air Pollution ◽

Cohort Study ◽

Lung Function ◽

Birth Cohort ◽

Birth Cohort Study ◽

Air Pollution Exposure ◽

Pollution Exposure

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Air Pollution Exposure and Infant Lung Function in the MACE Cohort, South Africa

Environmental Epidemiology ◽

10.1097/01.ee9.0000609000.48206.68 ◽

2019 ◽

Vol 3 ◽

pp. 280

Author(s):

Muttoo S ◽

Naidoo R ◽

Jeena P ◽

Asharam K

Keyword(s):

South Africa ◽

Air Pollution ◽

Lung Function ◽

Air Pollution Exposure ◽

Pollution Exposure

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Air Pollution Exposure in Walking School Bus Routes: A New Zealand Case Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph15122802 ◽

2018 ◽

Vol 15 (12) ◽

pp. 2802 ◽

Cited By ~ 3

Author(s):

Kim Dirks ◽

Jennifer Salmond ◽

Nicholas Talbot

Keyword(s):

Air Pollution ◽

New Zealand ◽

Traffic Safety ◽

Traffic Congestion ◽

Ultrafine Particle ◽

School Buses ◽

The Road ◽

Air Pollution Exposure ◽

Using Data ◽

Pollution Exposure

Walking School Buses (WSBs), organized groups for children to walk to school under the supervision of adults, help reduce traffic congestion and contribute towards exercise. Routes are based largely on need, traffic safety and travel time, with exposure to air pollution not generally considered. This paper explores whether reductions in exposure can be achieved based on the side of the road travelled using data collected in Auckland, New Zealand. Exposure to air pollution was measured for a 25-min commute consisting of a 10-min segment along a quiet cul-de-sac and a 15-min segment along a main arterial road with traffic congestion heavier in one direction. Two participants were each equipped with a portable P-Trak ultrafine particle monitor and a portable Langan carbon monoxide monitor, and walked the route on opposite sides of the road simultaneously, for both morning and afternoon, logging 10-s data. The results suggest that pedestrians travelling on the footpath next to the less congested side of the road in the morning avoid many short-term peaks in concentration and experience significantly lower mean exposures than those travelling on the footpath next to the more congested side. Significant reductions in air pollution exposure could be made for children by taking into account the side of the road in WSB route design.

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