A case-control study of risk factors associated with rectal colonization of extended-spectrum beta-lactamase producing sp. in newborn infants

Abstract Background Approximately 11% of patients colonized with extended-spectrum beta-lactamase producing Enterobacterales (ESBL-PE) are colonized with more than one ESBL-producing species. We investigated risk factors associated with colonization with multiple ESBL-PE species. Methods We performed a case-case–control study at the University Hospital Basel, Switzerland, including hospitalized patients colonized with ESBL-PE between 01/2008 and 12/2018. Patients colonized with multiple species of ESBL-PE during the same hospitalization were assigned to group 1. Group 2 consisted of patients with ESBL-PE and a newly acquired ESBL-PE-species identified during subsequent hospitalization. Controls (i.e., group 3) were patients with only one species of ESBL-PE identified over multiple hospitalizations. Controls were frequency-matched 3:1 to group 2 cases according to time-at-risk (i.e., days between ESBL-PE detection during first and subsequent hospitalizations) to standardize the duration of colonization. ESBL was identified with phenotypic assay and the presence of ESBL genes was confirmed by whole genome sequencing. Results Among 1559 inpatients, 154 cases met eligibility criteria (67 in group 1, 22 in group 2, 65 in group 3). International travel within the previous 12 months (OR 12.57, 95% CI 3.48–45.45, p < 0.001) and antibiotic exposure within the previous 3 months (OR 2.96, 95% CI 1.37–6.41, p = 0.006) were independently associated with co-colonization with multiple ESBL-PE species. Admission from another acute-care facility was the only predictor of replacement of one ESBL-PE species with another during subsequent hospitalizations (OR 6.02, 95% CI 1.15–31.49, p = 0.003). Conclusion These findings point to strain-related factors being the main drivers of co-colonization with different ESBL-PE and may support stratification of infection prevention and control measures according to ESBL-PE species/strains.

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Determination of risk factors associated with malnutrition among children under the age of five: a case control study at Arthur Davison children’s hospital in Ndola, Zambia

Asian Pacific Journal of Health Sciences ◽

10.21276/apjhs.2017.4.2.18 ◽

2017 ◽

Vol 4 (2) ◽

pp. 105-109 ◽

Cited By ~ 1

Author(s):

Maurice Mhango ◽

◽

Seter Siziya ◽

Victor Mwanakasale ◽

◽

...

Keyword(s):

Risk Factors ◽

Case Control Study ◽

Case Control ◽

Factors Associated ◽

Children's Hospital ◽

Children’S Hospital ◽

Control Study

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Effects of sagging breasts and other risk factors associated with mastalgia: a case–control study

Scientific Reports ◽

10.1038/s41598-021-82099-2 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Bülent Çomçalı ◽

Servet Kocaoz ◽

Buket Altun Özdemir ◽

Ömer Parlak ◽

Birol Korukluoğlu

Keyword(s):

Risk Factors ◽

Case Control Study ◽

Coffee Consumption ◽

Educational Status ◽

Case Control ◽

Tea Consumption ◽

Drinking Alcohol ◽

Factors Affecting ◽

Factors Associated ◽

Control Study

AbstractThe aim of this study is to compare patients with and without mastalgia and to analyze the factors affecting mastalgia and its severity. The patient’s age, height, weight, educational status, marital status, and occupation were recorded in all subjects. In addition, the women were asked about the presence of any risk factors for mastalgia, such as tea and coffee consumption, smoking, alcohol consumption, and weight gain. The sternal notch to nipple distance (SNND) was measured to determine whether there was breast sagging. Mastalgia was significantly more common in women with BMIs of > 30 kg/m2 (OR: 2.94, CI 1.65–5.24), those who were primary school graduates or illiterate (OR: 2.96, CI 1.6–5.46), and those with SNND values of 22–25 cm (OR: 2.94, CI 1.79–4.82). In these women, drinking more than 6 cups of tea a day (OR: 2.15, CI 1.32–3.5), smoking at least 10 cigarettes a day (OR: 2.94, CI 1.78–4.83), and drinking alcohol at least once a week (OR: 2.1, CI 1.12–3.91) were found to be important factors that increased the risk of mastalgia. As a result, it has been found that severe mastalgia complaints cause by obesity, sagging breasts, never giving birth, unemployment anxiety, regular smoking, alcohol use, and excessive tea consumption.

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