scholarly journals Serial or Parallel Metastasis of Cutaneous Melanoma? A Study of the German Central Malignant Melanoma Registry

2017 ◽  
Vol 137 (12) ◽  
pp. 2570-2577 ◽  
Author(s):  
Maximilian Gassenmaier ◽  
Thomas Kurt Eigentler ◽  
Ulrike Keim ◽  
Matthias Goebeler ◽  
Eckhard Fiedler ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Cutaneous Melanoma

scholarly journals Successful Treatment of a Patient with anti-PD1 Antibody-Resistant Advanced Mucosal Melanoma with Nivolumab, Ipilimumab plus Denosumab Combination Therapy

2020 ◽  
Vol 13 (1) ◽  
pp. 271-275 ◽  
Author(s):  
Taku Fujimura ◽  
Yumi Kambayashi ◽  
Kentaro Ohuchi ◽  
Ryo Amagai ◽  
Yota Sato ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Combination Therapy ◽  
Nasal Cavity ◽  
Immune Checkpoint ◽  
Cutaneous Melanoma ◽  
Japanese Population ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Mucosal Melanoma ◽  
Mutation Burden

Since the incidence of mucosal melanoma is higher in the Japanese population compared to Caucasians, and since mucosal melanoma possesses a lower mutation burden compared to cutaneous melanoma, the efficacy of anti-PD1 antibody (Ab) monotherapy for mucosal melanoma is limited. Therefore, other targeting molecules that enhance the anti-tumor effects of immune checkpoint inhibitors are needed. In this report, we present a case with anti-PD1 Ab-resistant recurrent malignant melanoma of the nasal cavity successfully treated with nivolu­mab, ipilimumab plus denosumab combination therapy.

scholarly journals Primary Cilium Depletion Typifies Cutaneous Melanoma In Situ and Malignant Melanoma

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e27410 ◽  
Author(s):  
Jinah Kim ◽  
Salma Dabiri ◽  
E. Scott Seeley
Keyword(s):  
Malignant Melanoma ◽  
Primary Cilium ◽  
Cutaneous Melanoma ◽  
Melanoma In Situ

Malignant melanoma of the vulva: An extension of cutaneous melanoma?

2011 ◽  
Vol 122 (3) ◽  
pp. 612-617 ◽  
Author(s):  
K.M. Moxley ◽  
A.N. Fader ◽  
P.G. Rose ◽  
A.S. Case ◽  
D.G. Mutch ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Cutaneous Melanoma

Recurrent primary vulvovaginal malignant melanoma arising in melanoma in situ – the natural history of lesions followed for 23 years

2004 ◽  
Vol 14 (4) ◽  
pp. 628-632
Author(s):  
N. J. Kingston ◽  
R. W. Jones ◽  
J. Baranyai
Keyword(s):  
Malignant Melanoma ◽  
Natural History ◽  
Metastatic Melanoma ◽  
Cutaneous Melanoma ◽  
Mucosal Melanoma ◽  
Histologic Examination ◽  
Melanoma In Situ ◽  
Pigmented Lesions ◽  
History Of

Multifocal melanoma and melanoma in situ of the vulva and vagina are uncommon lesions, and our understanding of their natural history is limited. Vulvovaginal melanoma appears to be biologically different from cutaneous melanoma and has more in common with mucosal melanoma. A 60-year-old woman presented in 1977 with a pigmented vulvar lesion. Histologic examination revealed melanoma in situ associated with focal invasive melanoma. She re-presented with recurrent primary melanomas arising in melanoma in situ in 1990 and 1998 and died of widespread metastatic melanoma in 2000. Melanoma in situ of the vulva and vagina is rare and appears to have a relatively slow but definite progression to invasive melanoma. All suspicious pigmented lesions in this region should be biopsied, and if multifocal in situ melanoma is identified, vulvo(vagin)ectomy should be considered.

HLA Antigens in Familial and Sporadic Cutaneous Melanoma

1988 ◽  
Vol 74 (6) ◽  
pp. 657-664 ◽  
Author(s):  
Dario Rovini ◽  
Giuseppe Pellegris ◽  
Natale Cascinelli ◽  
Laura Cantoni ◽  
Maurizio Vaglini ◽  
...  
Keyword(s):  
At Risk ◽  
Malignant Melanoma ◽  
Cutaneous Melanoma ◽  
Hla Antigens ◽  
Hla System ◽  
Significant Difference

One hundred and twenty-four subjects belonging to 25 families, 51 with familial malignant melanoma (FMM), and 186 subjects belonging to 41 families, 41 with sporadic malignant melanoma, were typed for the HLA A, B, C and DR loci of the HLA system. There was the same statistically significant difference in the frequency of the haplotype A9, B35, Cw4 between each group of patients and the respective healthy relatives (p = 0.01, p = 0.01 and p = 4 × 10−3, respectively). Moreover, the higher frequency of the haplotype A9, B35, Cw4 in the healthy members of the FMM families (42.46 %) compared with the healthy members of the SMM families (23.44 %) indicates that in the latter group other individuals are at risk for the disease. Furthermore, the different frequency of haplotypes B5, DR5 and B5, Cw1 suggests that differences exist between the two groups of healthy relatives. These observations confirm that the HLA region is involved in the etiology of malignant melanoma.

scholarly journals Primary Malignant Melanoma of Maxilla: Report of a Case with Discussion

2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
G. Shirisha Rani ◽  
T. Vinay Kumar ◽  
Balaram Kolasani ◽  
Md Rezwana Begum ◽  
Anu Priya Srinivasan
Keyword(s):  
Surgical Treatment ◽  
Malignant Melanoma ◽  
Oral Cavity ◽  
Head And Neck ◽  
Cutaneous Melanoma ◽  
Dental Clinic ◽  
Oral Melanoma ◽  
Pigmented Lesion ◽  
Oral Malignant Melanoma ◽  
Rule Out

Primary oral malignant melanoma, very rare neoplasm of melanocytic origin, usually presents as a bluish black to tan-brown colored lesion Which is accounting for 0.2 to 8% of all melanomas, 1.6% of all head and neck malignancies, and 0.5% of all oral neoplasia. In general, the prognosis of oral melanoma is poor and worse than that of cutaneous melanoma. Here a case of oral malignant melanoma is presented, which was undetected during the first visit to a dental clinic. When a simple oral surgical treatment was carried out in that region, it resulted in the appearance of a massive pigmented lesion which was histopathologically diagnosed as malignant melanoma. This paper is presented to reemphasize the fact that any pigmented lesion in the oral cavity should be viewed with suspicion and proper investigation (biopsy) should be carried out to rule out any untoward experiences later.

scholarly journals Metastatic Melanoma of the Gallbladder in an Asymptomatic Patient

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Asad Khan ◽  
Sejal Patel ◽  
Daniel J. Zaccarini ◽  
Mary McGrath
Keyword(s):  
Malignant Melanoma ◽  
Lymph Nodes ◽  
Metastatic Disease ◽  
Cutaneous Melanoma ◽  
Asymptomatic Patient ◽  
Open Cholecystectomy ◽  
Survival Rates ◽  
Review Of The Literature ◽  
Regional Lymph Nodes ◽  
History Of

Malignant Melanoma (MM) is among the most dangerous malignancies with some of the least known survival rates. Melanoma most commonly metastasizes to regional lymph nodes, the lungs, and brain. Metastatic disease of the gallbladder (GB) is exceptionally rare making it difficult to diagnose. The fact that typically patients do not present until they are symptomatic—only after widespread metastatic disease has already occurred—is further complicating the diagnosis of MM of the GB. For this reason, MM of the GB is rarely discovered in living patients. In fact, review of the literature showed only 40 instances in which metastatic disease of the GB was reported in living patients. We describe the presentation and management of a patient who had metastatic disease of the GB. However, our case is unique because his malignancy was discovered incidentally while he was asymptomatic. He was successfully treated with an open cholecystectomy. We have presented this case in order to make the necessity of meticulous investigation of potential metastasis in patients with a known history of cutaneous melanoma clear.

Evaluation of the Risk of Multiple Primaries in Malignant Cutaneous Melanoma

1976 ◽  
Vol 62 (1) ◽  
pp. 127-130 ◽  
Author(s):  
Umberto Veronesi ◽  
Natale Cascinelli ◽  
Rosaria Bufalino
Keyword(s):  
Malignant Melanoma ◽  
General Population ◽  
National Cancer Institute ◽  
Cutaneous Melanoma ◽  
Primary Melanoma ◽  
Second Primary ◽  
Multiple Primaries ◽  
Malignant Cutaneous Melanoma ◽  
Malignant Melanoma Patient ◽  
Age And Sex

The evaluation of the risk of a second primary melanoma has been done on a series of 521 cases of malignant melanoma observed at the National Cancer Institute of Milan from September 1967 to December 1974. It has been found that a malignant melanoma patient is about 900 times more likely to have a second primary than an individual in the general population is likely to contract the disease. The risk is age and sex dependent.

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