Incidence of Epidermal Necrolysis: Results of the German Registry

Ciltacabtagene autoleucel (cilta-cel) is a Chimeric antigen receptor T-cell therapy with the potential for long-term disease control in heavily pre-treated patients with relapsed/refractory multiple myeloma (RRMM). As cilta-cel was assessed in the single-arm CARTITUDE-1 clinical trial, we used an external cohort of patients from the Therapie Monitor registry fulfilling the CARTITUDE-1 inclusion criteria to evaluate the effectiveness of cilta-cel for overall survival (OS) and time to next treatment (TTNT) vs. real-world clinical practice. Individual patient data allowed us to adjust the comparisons between both cohorts, using the inverse probability of treatment weighting (IPW; average treatment effect in the treated population (ATT) and overlap population (ATO) weights) and multivariable Cox proportional hazards regression. Outcomes were compared in intention-to-treat (HR, IPW-ATT: TTNT: 0.13 (95% CI: 0.07, 0.24); OS: 0.14 (95% CI: 0.07, 0.25); IPW-ATO: TTNT: 0.24 (95% CI: 0.12, 0.49); OS: 0.26 (95% CI: 0.13, 0.54)) and modified intention-to-treat (HR, IPW-ATT: TTNT: 0.24 (95% CI: 0.09, 0.67); OS: 0.26 (95% CI: 0.08, 0.84); IPW-ATO: TTNT: 0.26 (95% CI: 0.11, 0.59); OS: 0.31 (95% CI: 0.12, 0.79)) populations. All the comparisons were statistically significant in favor of cilta-cel. These results highlight cilta-cel’s potential as a novel, effective treatment to address unmet needs in patients with RRMM.

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Patients with metastatic non-small cell lung cancer without molecular alterations or PD-L1 expression in Germany: Treatment and first outcome from the prospective German Registry Platform CRISP (AIO-TRK-0315)

Annals of Oncology ◽

10.1093/annonc/mdz260.022 ◽

2019 ◽

Vol 30 ◽

pp. v616

Author(s):

F. Griesinger ◽

W.E.E. Eberhardt ◽

H.-R. Bruch ◽

J. Rauh ◽

E. von der Heyde ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Small Cell ◽

Small Cell Lung ◽

Molecular Alterations ◽

German Registry

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Standardisierte histomorphologische Aufarbeitung von Peritonealbiopsien im Rahmen des Deutschen Peritonealbiopsieregisters (GRIP, German Registry In PD)

Der Pathologe ◽

10.1007/s00292-020-00815-7 ◽

2020 ◽

Vol 41 (6) ◽

pp. 634-642

Author(s):

Frederick Pfister ◽

Maike Büttner-Herold ◽

Benno Kitsche ◽

Dirk R. Bulian ◽

Jan Kielstein ◽

...

Keyword(s):

German Registry ◽

Entzündliche Veränderungen

Zusammenfassung Das Peritoneum stellt als seröse Haut, die mit ihrem viszeralen und parietalen Anteil den Bauchraum auskleidet, ein interessantes Organ dar, welches bei der sog. Peritoneal- oder Bauchfelldialyse (PD) klinische Beachtung findet. Bei diesem Nierenersatzverfahren wird die Semipermeabilität des Peritoneums genutzt, um mittels unterschiedlich osmolarer Dialyseflüssigkeiten die sog. harnpflichtigen Substanzen aus dem Körper zu eliminieren. Dies ist insbesondere bei jungen Patienten eine ideales Nierenersatzverfahren und funktioniert in der Regel zumindest einige Zeit sehr gut. Vorschäden des Peritoneums durch die Grunderkrankung der chronischen Niereninsuffizienz oder assoziierte Komorbiditäten sowie v. a. entzündliche Veränderungen während der PD führen zu einem morphologischen Umbau des Peritoneums mit der Konsequenz des Verlusts der Filtereigenschaften, sodass die PD beendet und auf ein anderes Nierenersatzverfahren gewechselt werden muss. Die Kenntnis des morphologischen Umbaus des Peritoneums sowie möglicher begünstigender Faktoren, zu denen es derzeit noch zu wenige Daten gibt, ist wichtig für die Therapie und Prognose der Patienten, die mit PD behandelt werden. Aus diesem Grund wurde vor einigen Jahren das Deutsche Peritonealbiopsieregister (GRIP, German Registry In PD) gegründet, das mittlerweile knapp 1700 Biopsate umfasst und an diesen standardisiert klinische und histomorphologische Parameter erhebt und dokumentiert.

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2995Risk prediction in patients with venoarterial extracorporeal membrane oxygenation for cardiopulmonary support: insights from a German registry

European Heart Journal ◽

10.1093/eurheartj/ehy563.2995 ◽

2018 ◽

Vol 39 (suppl_1) ◽

Author(s):

P M Becher ◽

C R Sinning ◽

B Schrage ◽

N F Fluschnik ◽

C R Waldeyer ◽

...

Keyword(s):

Extracorporeal Membrane Oxygenation ◽

Membrane Oxygenation ◽

Cardiopulmonary Support ◽

Venoarterial Extracorporeal Membrane Oxygenation ◽

German Registry

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German Registry for Acute Aortic Dissection Type A (GERAADA) - New Software Design, Parameters and Their Definitions

The Thoracic and Cardiovascular Surgeon ◽

10.1055/s-0030-1250748 ◽

2011 ◽

Vol 59 (02) ◽

pp. 69-77 ◽

Cited By ~ 8

Author(s):

E. Weigang ◽

C. Görgen ◽

K. Kallenbach ◽

O. Dapunt ◽

M. Karck

Keyword(s):

Aortic Dissection ◽

Software Design ◽

Acute Aortic Dissection ◽

Type A ◽

Design Parameters ◽

German Registry ◽

Aortic Dissection Type A

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Prediction of mortality rate in acute type A dissection: the German Registry for Acute Type A Aortic Dissection score

European Journal of Cardio-Thoracic Surgery ◽

10.1093/ejcts/ezaa156 ◽

2020 ◽

Vol 58 (4) ◽

pp. 700-706 ◽

Cited By ~ 4

Author(s):

Martin Czerny ◽

Matthias Siepe ◽

Friedhelm Beyersdorf ◽

Manuel Feisst ◽

Michael Gabel ◽

...

Keyword(s):

Mortality Rate ◽

Aortic Dissection ◽

Type A ◽

Acute Type ◽

Data Set ◽

Web Based ◽

Final Model ◽

Type A Aortic Dissection ◽

Prediction Of Mortality ◽

German Registry

Abstract OBJECTIVES The goal was to develop a scoring system to predict the 30-day mortality rate for patients undergoing surgery for acute type A aortic dissection on the basis of the German Registry for Acute Type A Aortic Dissection (GERAADA) data set and to provide a Web-based application for standard use. METHODS A total of 2537 patients enrolled in GERAADA who underwent surgery between 2006 and 2015 were analysed. Variable selection was performed using the R-package FAMoS. The robustness of the results was confirmed via the bootstrap procedure. The coefficients of the final model were used to calculate the risk score in a Web-based application. RESULTS Age [odds ratio (OR) 1.018, 95% confidence interval (CI) 1.009–1.026; P < 0.001; 5-year OR: 1.093], need for catecholamines at referral (OR 1.732, 95% CI 1.340–2.232; P < 0.001), preoperative resuscitation (OR 3.051, 95% CI 2.099–4.441; P < 0.001), need for intubation before surgery (OR 1.949, 95% CI 1.465–2.585; P < 0.001), preoperative hemiparesis (OR 1.442, 95% CI 0.996–2.065; P = 0.049), coronary malperfusion (OR 1.870, 95% CI 1.386–2.509; P < 0.001), visceral malperfusion (OR 1.748, 95% CI 1.198–2.530; P = 0.003), dissection extension to the descending aorta (OR 1.443, 95% CI 1.120–1.864; P = 0.005) and previous cardiac surgery (OR 1.772, 95% CI 1.048–2.903; P = 0.027) were independent predictors of the 30-day mortality rate. The Web application based on the final model can be found at https://www.dgthg.de/de/GERAADA_Score. CONCLUSIONS The GERAADA score is a simple, effective tool to predict the 30-day mortality rate for patients undergoing surgery for acute type A aortic dissection. We recommend the widespread use of this Web-based application for standard use.

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