scholarly journals Tryptophan-mediated Dimerization of the TssL Transmembrane Anchor Is Required for Type VI Secretion System Activity

2018 ◽  
Vol 430 (7) ◽  
pp. 987-1003 ◽  
Author(s):  
Abdelrahim Zoued ◽  
Jean-Pierre Duneau ◽  
Eric Durand ◽  
Alexandre P. España ◽  
Laure Journet ◽  
...  
Keyword(s):  
Secretion System ◽  
Type Vi Secretion System ◽  
System Activity ◽  
Type Vi Secretion ◽  
Transmembrane Anchor

scholarly journals Inhibiting Type VI Secretion System Activity with a Biomimetic Peptide Designed To Target the Baseplate Wedge Complex

mBio ◽  
2021 ◽  
Author(s):  
Y. Cherrak ◽  
I. Filella-Merce ◽  
V. Schmidt ◽  
D. Byrne ◽  
V. Sgoluppi ◽  
...  
Keyword(s):  
Virulence Factors ◽  
Secretion System ◽  
Bacterial Virulence ◽  
Therapeutic Options ◽  
Drug Resistant ◽  
Type Vi Secretion System ◽  
System Activity ◽  
Type Vi Secretion ◽  
Life Threatening

New therapeutic options are urgently needed to fight drug-resistant and life-threatening infections. In contrast to antibiotics that inhibit the growth pathways of bacteria, the antivirulence strategy is a promising approach to disarm pathogens by interfering with bacterial virulence factors without exerting evolutionary pressure.

scholarly journals Clinical impact of the type VI secretion system on virulence of Campylobacter species during infection

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Jessica Agnetti ◽  
Helena M. B. Seth-Smith ◽  
Sebastian Ursich ◽  
Josiane Reist ◽  
Marek Basler ◽  
...  
Keyword(s):  
Secretion System ◽  
Clinical Impact ◽  
Type Vi Secretion System ◽  
Type Vi Secretion ◽  
Campylobacter Species
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