scholarly journals The impact of metastasis on the mineral phase of vertebral bone tissue

2017 ◽  
Vol 69 ◽  
pp. 75-84 ◽  
Author(s):  
Mikhail Burke ◽  
Ayelet Atkins ◽  
Alex Kiss ◽  
Margarete Akens ◽  
Albert Yee ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Mineral Phase ◽  
Vertebral Bone ◽  
The Impact

Bone tissue engineering in the greater omentum with computer-aided design/computer-aided manufacturing scaffolds is enhanced by a periosteum transplant

2020 ◽  
Author(s):  
Hendrik Naujokat ◽  
Klaas Loger ◽  
Juliane Schulz ◽  
Yahya Açil ◽  
Jörg Wiltfang
Keyword(s):  
Bone Formation ◽  
Bone Tissue ◽  
Computer Aided Design ◽  
Bone Tissue Regeneration ◽  
Histological Evaluation ◽  
Greater Omentum ◽  
Collagen Membrane ◽  
Computer Aided ◽  
3D Printed ◽  
The Impact

Aim: This study aimed to evaluate two different vascularized bone flap scaffolds and the impact of two barrier membranes for the reconstruction of critical-size bone defects. Materials & methods: 3D-printed scaffolds of biodegradable calcium phosphate and bioinert titanium were loaded with rhBMP-2 bone marrow aspirate, wrapped by a collagen membrane or a periosteum transplant and implanted into the greater omentum of miniature pigs. Results: Histological evaluation demonstrated significant bone formation within the first 8 weeks in both scaffolds. The periosteum transplant led to enhanced bone formation and a homogenous distribution in the scaffolds. The omentum tissue grew out a robust vascular supply. Conclusion: Endocultivation using 3D-printed scaffolds in the greater omentum is a very promising approach in defect-specific bone tissue regeneration.

scholarly journals Design and Mechanical Properties Verification of Gradient Voronoi Scaffold for Bone Tissue Engineering

Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 664
Author(s):  
Haiyuan Zhao ◽  
Yafeng Han ◽  
Chen Pan ◽  
Ding Yang ◽  
Haotian Wang ◽  
...  
Keyword(s):  
Mechanical Property ◽  
Tissue Engineering ◽  
Elastic Modulus ◽  
Porous Structure ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Voronoi Tessellation ◽  
Impact Resistance ◽  
Natural Bone ◽  
The Impact

In order to obtain scaffold that can meet the therapeutic effect, researchers have carried out research on irregular porous structures. However, there are deficiencies in the design method of accurately controlling the apparent elastic modulus of the structure at present. Natural bone has a gradient porous structure. However, there are few studies on the mechanical property advantages of gradient bionic bone scaffold. In this paper, an improved method based on Voronoi-tessellation is proposed. The method can get controllable gradient scaffolds to fit the modulus of natural bone, and accurately control the apparent elastic modulus of porous structure, which is conducive to improving the stress shielding. To verify the designed structure can be fabricated by additive manufacturing, several designed models are obtained by SLM and EBM. Through finite element analysis (FEA), it is verified that the irregular porous structure based on Voronoi-tessellation is more stable than the traditional regular porous structure of the same structure volume, the same pore number and the same material. Furthermore, it is verified that the gradient irregular structure has a better stability than the non-gradient structure. An experiment is conducted successfully to verify the stability performance got by FEA. In addition, a dynamic impact FEA is also performed to simulate impact resistance. The result shows that the impact resistance of the regular porous structure, the irregular porous structure and the gradient irregular porous structure becomes better in turn. The mechanical property verification provides a theoretical basis for the structural design of gradient irregular porous bone tissue engineering scaffolds.

In Vitro Bio-Mineralization Process

2007 ◽  
Vol 361-363 ◽  
pp. 543-546
Author(s):  
Monica Sandri ◽  
Anna Tampieri ◽  
Luca Bertinetti ◽  
Adele Boskey
Keyword(s):  
Bone Tissue ◽  
Mineralization Process ◽  
Mineral Phase ◽  
Composites Materials ◽  
Physico Chemical ◽  
Biomimetic Approach

The present work describes the development of biomimetic composites materials for bone tissue substitution and repair. At this purpose a biomimetic approach was used and apatitic phases were nucleated on macromolecular matrices like natural collagen, which act as template and induce peculiar physico-chemical features in the mineral phase.

Determination of Residual Stress with Diffusion MR Method in Cortical and Trabecular Sections of Human Vertebral Bone Tissue

2021 ◽  
Vol 27 (3) ◽  
pp. 215-218
Author(s):  
Cemil Sert ◽  
◽  
Abdurrahim Dusak ◽  
Mehmet Akif Altay ◽  
◽  
...  
Keyword(s):  
Residual Stress ◽  
Bone Tissue ◽  
Vertebral Bone ◽  
Diffusion Mr

scholarly journals Environmental Impact for 3D Bone Tissue Engineering Scaffolds Life Cycle: An Assessment

2021 ◽  
Vol 12 (5) ◽  
pp. 6504-6515
Keyword(s):  
Tissue Engineering ◽  
Life Cycle Assessment ◽  
Life Cycle ◽  
Environmental Impact ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Environmental Impacts ◽  
Tissue Engineering Scaffolds ◽  
Industrial Soil ◽  
The Impact

With the development of additive manufacturing technology, 3D bone tissue engineering scaffolds have evolved. Bone tissue engineering is one of the techniques for repairing bone abnormalities caused by a variety of circumstances, such as injuries or the need to support damaged sections. Many bits of research have gone towards developing 3D bone tissue engineering scaffolds all across the world. The assessment of the environmental impact, on the other hand, has received less attention. As a result, the focus of this study is on developing a life cycle assessment (LCA) model for 3D bone tissue engineering scaffolds and evaluating potential environmental impacts. One of the methodologies to evaluating a complete environmental impact assessment is life cycle assessment (LCA). The cradle-to-grave method will be used in this study, and GaBi software was used to create the analysis for this study. Previous research on 3D bone tissue engineering fabrication employing poly(ethylene glycol) diacrylate (PEGDA) soaked in dimethyl sulfoxide (DMSO), and diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide (TPO) as a photoinitiator will be reviewed. Meanwhile, digital light processing (DLP) 3D printing is employed as the production technique. The GaBi program and the LCA model developed to highlight the potential environmental impact. This study shows how the input and output of LCA of 3D bone tissue engineering scaffolds might contribute to environmental issues such as air, freshwater, saltwater, and industrial soil emissions. The emission contributing to potential environmental impacts comes from life cycle input, electricity and transportation consumption, manufacturing process, and material resources. The results from this research can be used as an indicator for the researcher to take the impact of the development of 3D bone tissue engineering on the environment seriously.

scholarly journals Level of Osteotropic Elements in the Jaw Bones of Experimental Animals in Terms of the Impact of Xenobiotics

2019 ◽  
Vol 26 (2) ◽  
Author(s):  
Mariana Kaminska ◽  
Mykola Rozhko ◽  
Hanna Ersteniuk
Keyword(s):  
Heavy Metals ◽  
Bone Tissue ◽  
Male Rats ◽  
Control Group ◽  
Metabolic Processes ◽  
Jaw Bone ◽  
Intact Group ◽  
Jaw Bones ◽  
Zinc Levels ◽  
The Impact

Pollution of the environment with heavy metals, pesticides, nitrates leads to an unceasing deterioration of the population’s health, in particular, the dental one. Excessive intake of salts of heavy metals and nitrites is accompanied by changes in calcium-phosphorus metabolism rates, indicating a disorder of metabolic processes in bone tissue. This necessitates the study of the level of osteotropic elements of the jaw bone tissue. Materials and methods of research. In the experiment on 80 white outbred male rats, the effects of cadmium chloride, sodium nitrite and their combined action on the content of osteotropic elements in the jaw bone were studied. The control group consisted of 10 intact animals. Results. It was determined that in the dynamics (1st, 14th, 28th days) of both cadmium-nitrite, nitrite and cadmium intoxication there was observed the accumulation of cadmium and decrease of calcium, copper, zinc levels in bone tissue of animal jaws compared to intact group. Conclusions.The most significant changes in the level of osteotropic elements in the jaw bones are found in the combined effect of xenobiotics, which is important for understanding of the metabolic processes in the oral cavity.

Bone density, microarchitecture and tissue quality after 1 year of treatment with dolutegravir/abacavir/lamivudine

2020 ◽  
Vol 75 (10) ◽  
pp. 2998-3003
Author(s):  
Jade Soldado-Folgado ◽  
Elisabeth Lerma-Chippirraz ◽  
Itziar Arrieta-Aldea ◽  
Daniel Bujosa ◽  
Natalia García-Giralt ◽  
...  
Keyword(s):  
Trabecular Bone ◽  
Bone Tissue ◽  
Bone Quality ◽  
Bone Health ◽  
Trabecular Bone Score ◽  
Bone Microarchitecture ◽  
Tissue Quality ◽  
Art Initiation ◽  
The Impact ◽  
Health Parameters

Abstract Background Bone mineral density (BMD) decreases with ART initiation with a tenofovir disoproxil fumarate-containing regimen, although bone tissue quality increases. The impact of dolutegravir (DTG)/abacavir (ABC)/lamivudine (3TC)-based ART initiation on bone health parameters is not clear. Objectives To study the impact of DTG/ABC/3TC-based therapy on bone health parameters in ART-naive individuals with HIV after 48 weeks of treatment. Methods An observational, prospective and analytical study of treatment-naive patients with HIV undergoing a DTG/ABC/3TC-based regimen at 48 week follow-up. Changes in bone strength parameters (BMD, bone microarchitecture and bone tissue quality) were assessed with non-parametric methods. Results Sixteen HIV-infected ART-naive patients starting DTG/ABC/3TC were included. BMD in the lumbar spine showed a significant decrease of −2.25% (P = 0.007) and −4.1% in the femoral neck (P = 0.007). Bone microarchitecture, as measured by trabecular bone score, also decreased significantly by −2.5% (P = 0.03). In contrast, bone quality [bone material strength index (BMi)], as measured by microindentation, significantly increased with respect to baseline after 48 weeks of treatment, showing better bone properties of +6.53% (P < 0.001). No significant changes were found in bone turnover markers. In addition, a positive significant correlation between the CD4/CD8 cell count ratio at baseline and changes in BMSi after 48 weeks of treatment was observed (Spearman’s rho = 0.4974; P = 0.04). Conclusions After a 48 week treatment with DTG/ABC/3TC-based ART, BMD and trabecular bone score decreased while bone tissue quality, as measured by microindentation, improved significantly. The state of the immune system at ART initiation is related to bone quality recovery. An overarching approach to assess bone toxicity in ART-treated patients is needed.

scholarly journals Mathematical and computational models for bone tissue engineering in bioreactor systems

2019 ◽  
Vol 10 ◽  
pp. 204173141982792 ◽  
Author(s):  
Iva Burova ◽  
Ivan Wall ◽  
Rebecca J Shipley
Keyword(s):  
Bone Tissue ◽  
Computational Models ◽  
Bone Grafts ◽  
Operating Conditions ◽  
Specific Cell ◽  
Production Models ◽  
Flow Speeds ◽  
Comprehensive Framework ◽  
The Impact

Research into cellular engineered bone grafts offers a promising solution to problems associated with the currently used auto- and allografts. Bioreactor systems can facilitate the development of functional cellular bone grafts by augmenting mass transport through media convection and shear flow-induced mechanical stimulation. Developing successful and reproducible protocols for growing bone tissue in vitro is dependent on tuning the bioreactor operating conditions to the specific cell type and graft design. This process, largely reliant on a trial-and-error approach, is challenging, time-consuming and expensive. Modelling can streamline the process by providing further insight into the effect of the bioreactor environment on the cell culture, and by identifying a beneficial range of operational settings to stimulate tissue production. Models can explore the impact of changing flow speeds, scaffold properties, and nutrient and growth factor concentrations. Aiming to act as an introductory reference for bone tissue engineers looking to direct their experimental work, this article presents a comprehensive framework of mathematical models on various aspects of bioreactor bone cultures and overviews modelling case studies from literature.

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