Peripheral blood regulatory T cell measurements correlate with serum vitamin D levels in patients with multiple sclerosis

2009 ◽  
Vol 213 (1-2) ◽  
pp. 135-141 ◽  
Author(s):  
Walter Royal III ◽  
Younus Mia ◽  
Huifen Li ◽  
Kerry Naunton
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
T Cell ◽  
Regulatory T Cell ◽  
Peripheral Blood ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Vitamin D Levels

scholarly journals No correlation was observed between vitamin D levels and disability of patients with multiple sclerosis between latitudes 18° and 30° South

2017 ◽  
Vol 75 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Yara Dadalti Fragoso ◽  
Tarso Adoni ◽  
Soniza Vieira Alves-Leon ◽  
Samira L. Apostolos-Pereira ◽  
Walter Oleschko Arruda ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Large Population ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Serum Vitamin D ◽  
Control Subjects ◽  
Vitamin D Levels ◽  
The Mean ◽  
25 Oh Vitamin D

ABSTRACT Objective: Vitamin D has taken center stage in research and treatment of multiple sclerosis (MS). The objective of the present study was to assess the serum vitamin D levels of a large population of patients with MS and controls living in a restricted tropical area. Methods: Data from 535 patients with MS and 350 control subjects were obtained from 14 cities around the Tropic of Capricorn. Results: The mean serum 25-OH vitamin D level was 26.07 ± 10.27 ng/mL for the control subjects, and 28.03 ± 12.19 ng/mL for patients with MS. No correlation was observed between vitamin D levels and the disability of patients over the disease duration. Conclusion: At least for the region around the Tropic of Capricorn, serum levels of vitamin D typically are within the range of 20 to 30 ng/mL for controls and patients with MS.

KLOTO rs1207588 allelic variant affects serum vitamin D levels in multiple sclerosis patients

2019 ◽  
Vol 493 ◽  
pp. S614
Author(s):  
L. Agnello ◽  
C. Scazzone ◽  
B. Lo Sasso ◽  
G. Bivona ◽  
G. Iacolino ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Serum Vitamin ◽  
Allelic Variant ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Multiple Sclerosis Patients

Vitamin D levels and risk of multiple sclerosis in patients with clinically isolated syndromes

2013 ◽  
Vol 20 (2) ◽  
pp. 147-155 ◽  
Author(s):  
Vittorio Martinelli ◽  
Gloria Dalla Costa ◽  
Bruno Colombo ◽  
Dacia Dalla Libera ◽  
Alessandro Rubinacci ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Brain Magnetic Resonance Imaging ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Clinically Isolated Syndromes ◽  
Vitamin D Levels ◽  
Magnetic Resonance Imaging Mri

Background: Growing evidence suggests that vitamin D deficiency may be one of the most important environmental factors for the development of multiple sclerosis (MS). Objectives: The objectives of this paper are to evaluate serum 25-hydroxyvitamin D (25(OH)D) levels in patients with clinically isolated syndromes (CIS) and to examine whether they are related to MS risk. Methods: This is a retrospective study of 100 CIS patients hospitalized from 2000 to 2009 at San Raffaele Hospital, Milan, Italy. We evaluated baseline 25(OH)D level as well as clinical, brain magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) data. Results: A total of 52% of CIS patients had vitamin D deficiency (25(OH)D < 50 nmol/l). During follow-up (median: 7.17 years), 55 patients developed clinically definite MS (CDMS). Patients with very low (< 10th percentile) and low (< 25th percentile) 25(OH)D levels were particularly at risk of CDMS (HRs (95% CIs): 2.12 (0.91–4.96) and 1.61 (0.85–3.03), respectively), while no further reduction in the HRs of disease was observed at high levels of 25(OH)D. This association was even stronger after adjustment for additional risk factors for CDMS development (HRs (95% CIs) for 25(OH)D levels < 10th and 25th percentiles: 3.34 (1.32–8.45) and 2.04 (0.96–4.36), respectively). Conclusion: Low serum vitamin D is associated with increased MS risk in patients with CIS.

scholarly journals Association Between Serum Vitamin D Levels and Frequency of Relapses in Patients With Multiple Sclerosis

Cureus ◽  
2021 ◽  
Author(s):  
Farah Mansoor ◽  
Vikash Kumar ◽  
Suneel Kumar ◽  
Navneet Kaur ◽  
Sidra Naz ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Vitamin D Levels

scholarly journals Influence of physical activity on serum vitamin D levels in people with multiple sclerosis

PLoS ONE ◽  
2020 ◽  
Vol 15 (6) ◽  
pp. e0234333
Author(s):  
Angelika Bauer ◽  
Ivan Lechner ◽  
Michael Auer ◽  
Thomas Berger ◽  
Gabriel Bsteh ◽  
...  
Keyword(s):  
Physical Activity ◽  
Multiple Sclerosis ◽  
Vitamin D ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Vitamin D Levels

scholarly journals Association of serum vitamin D levels in Japanese patients with multiple sclerosis

2013 ◽  
Vol 4 (2) ◽  
pp. 193-200 ◽  
Author(s):  
Masaaki Niino ◽  
Toshiyuki Fukazawa ◽  
Yusei Miyazaki ◽  
Naoya Minami ◽  
Jun Tashiro ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Serum Vitamin ◽  
Japanese Patients ◽  
Serum Vitamin D ◽  
Vitamin D Levels

scholarly journals Serum Vitamin D as a Marker of Impaired Information Processing Speed and Early Disability in Multiple Sclerosis Patients

2021 ◽  
Vol 11 (11) ◽  
pp. 1521
Author(s):  
Eleonora Virgilio ◽  
Domizia Vecchio ◽  
Ilaria Crespi ◽  
Paolo Barbero ◽  
Beatrice Caloni ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Information Processing ◽  
Processing Speed ◽  
Serum Vitamin ◽  
Hypovitaminosis D ◽  
Information Processing Speed ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Slowed information processing speed (IPS) is the hallmark and first cognitive domain to be altered in multiple sclerosis (MS) patients. Insufficient serum vitamin D was previously associated with disease development, relapses, and progression, but little is reported on cognition. However, vitamin D and cognitive impairment (CI) in other neurodegenerative diseases have already been linked. We explored the possible correlation between vitamin D and IPS at diagnosis and early disability at last follow-up in 81 MS patients. At diagnosis, we collected vitamin D levels and performed a Symbol Digit Modalities Test (SDMT). Raw scores were adjusted for age, gender, and educational level. Early disability was evaluated with MS severity score (MSSS) and age-related MSSS (ARMSS). A total of 71 patients (86.58%) showed hypovitaminosis D (19.71 ± 8.76 ng/mL) and 18 patients (21.95%) had CI. Patients with CI showed severe hypovitaminosis D (p = 0.004). No patients with sufficient vitamin D levels had CI. We found a positive correlation between vitamin D levels at diagnosis and (1) SDMT raw and z-score that persisted after correction for sunlight exposure and MRI baseline characteristics, and (2) EDSS, MSSS, and ARMSS after a mean 2 year follow-up. Low vitamin D levels may affect both cognition and early disability in newly diagnosed MS patients.

scholarly journals Ultraviolet B Phototherapy Intervention in Patients with Multiple Sclerosis: A Prospective, Randomized Pilot Trial

2019 ◽  
Vol 3 (1) ◽  
pp. 12-25
Author(s):  
Robert W. Motl ◽  
Grace M. Niemiro ◽  
Michael De Lisio ◽  
Sarah Sommer ◽  
Barry J. Riskin ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Pilot Trial ◽  
Serum Vitamin ◽  
Ultraviolet B ◽  
Serum Vitamin D ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
Uvb Phototherapy

Background There is substantial evidence, from well-conducted epidemiological studies, that low vitamin D levels are correlated with increased risk for MS, and multiple case control studies have implicated the involvement of vitamin D deficiency in MS etiology. Narrow-band Ultraviolet B (NB-UVB; 300nm - 311 nm) induced vitamin D production has not previously been studied in a multiple sclerosis (MS) randomized placebo-controlled trial (RCT). Objectives To investigate NB-UVB induced vitamin D production, immunomodulation and MS symptomology following NB-UVB phototherapy in a MS cohort. Methods Using a blinded RCT study design, twelve individuals 18 years or older with MS were enrolled and assigned (1:1) into individualized NB-UVB dose (10-30kJ/m) phototherapy, or into placebo treatment, delivered 3 times per week, for 8-weeks. Serum vitamin D levels, walking performance, strength, cognitive function, mood and circulating progenitor cells (CPCs: CD34+CD45dim), monocyte populations (Intermediate CD14+CD16+, Classical CD14+CD16-), and T regulatory cell (CD4+/CD25+/FoxP3+Tregs) count were assesed. The data were analyzed by 2 x 3 mixed factor ANOVA. Results A statistically significant condition by time interaction on vitamin D levels (F=7.14, p<.005, partial η2=.42) was identified. NB-UVB phototherapy may provide immunomodulation in a select group of MS individuals. Conclusion UVB phototherapy corrects vitamin D deficiency. This study adds to the growing research investigating UVB treatment in MS.

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