Midlife vitamin d deficiency is associated with later-life depression in ageing women: data from the women’s healthy ageing project (whap)

2017 ◽  
Vol 381 ◽  
pp. 158
Author(s):  
L. Skazlic ◽  
A. Goodwill ◽  
C. Szoeke
2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Stephen J. Genuis

Juxtaposed with monumental improvement in maternal-fetal outcomes over the last century, there has been the recent emergence of rising rates of gestational complications including preterm birth, operative delivery, and gestational diabetes. At the same time, there has been a burgeoning problem with widespread vitamin D deficiency among populations of many developed nations. This paper provides a brief review of potential health outcomes recently linked to gestational vitamin D deficiency, including preterm birth, cesarean delivery, and gestational diabetes. Although immediate costs for obstetric complications related to gestational vitamin D insufficiency may be modest, the short- and long-term costs for pediatric healthcare resulting from such gestational complications may be enormous and present an enduring burden on healthcare systems. With increasing evidence pointing to fetal origins of some later life disease, securing vitamin D sufficiency in pregnancy appears to be a simple, safe, and cost-effective measure that can be incorporated into routine preconception and prenatal care in the offices of primary care clinicians. Education on gestational nutritional requirements should be a fundamental part of medical education and residency training, instruction that has been sorely lacking to date.


2019 ◽  
Vol 241 (2) ◽  
pp. R65-R80 ◽  
Author(s):  
Folami Y Ideraabdullah ◽  
Anthony M Belenchia ◽  
Cheryl S Rosenfeld ◽  
Seth W Kullman ◽  
Megan Knuth ◽  
...  

Vitamin D is an essential nutrient that is metabolized in the body to generate an active metabolite (1,25(OH)2D) with hormone-like activity and highly diverse roles in cellular function. Vitamin D deficiency (VDD) is a prevalent but easily preventable nutritional disturbance. Emerging evidence demonstrates the importance of sufficient vitamin D concentrations during fetal life with deficiencies leading to long-term effects into adulthood. Here, we provide a detailed review and perspective of evidence for the role of maternal VDD in offspring long-term health, particularly as it relates to developmental origins of health and disease (DOHaD). We focus on the roles in neurobehavioral and cardiometabolic disorders in humans and highlight recent findings from zebrafish and rodent models that probe potential mechanisms linking early life VDD to later life health outcomes. Moreover, we explore evidence implicating epigenetic mechanisms as a mediator of this link. Gaps in our current understanding of how maternal VDD might result in deleterious offspring outcomes later in life are also addressed.


2012 ◽  
Vol 4 (1) ◽  
pp. 49-55 ◽  
Author(s):  
S. A. Lanham ◽  
C. Roberts ◽  
A. K. Habgood ◽  
S. Alexander ◽  
T. H. J. Burne ◽  
...  

During foetal development, calcium requirements are met as a consequence of maternal adaptations independent of vitamin D status. In contrast, after birth, dependency on vitamin D appears necessary for calcium metabolism and skeletal health. We used a rodent model (Sprague-Dawley rats), to determine if maternal vitamin D deficiency during pregnancy had a deleterious effect on bone structure at birth. Vitamin D deplete females were maintained under deplete conditions until birth of the pups, whereupon all dams were fed a vitamin D replete diet. Offspring were harvested at birth, and 140 days of age. Bones were analyzed using micro-computed tomography and strength tested to study differences in bone structure, density and strength and subjected to elemental analysis using plasma mass spectrometry to determine strontium, barium and calcium contents. Offspring from deplete mothers displayed altered trabecular parameters in the femur at birth and 140 days of age. In addition, at 140 days of age there was evidence of premature mineralization of the secondary ossification centre of the femoral head. Elemental analysis showed increased strontium uptake in the femur of the developmentally vitamin D-deficient offspring. Vitamin D depletion during development in the offspring may have a long-lasting effect, despite repletion of vitamin D from birth. This may have consequences for human health given the low vitamin D levels seen during pregnancy and current lifestyle of sun avoidance due to the risk of skin cancer.


2013 ◽  
Vol 5 (1) ◽  
pp. 6 ◽  
Author(s):  
Yasser F. Aly ◽  
Mohamed A. El Koumi ◽  
Rehab N. Abd El Rahman

Maternal vitamin D deficiency is not uncommon. The lack of vitamin D during pregnancy may result in poor fetal growth and altered neonatal development that may persist into later life. Recognition of risk factors and early detection of vitamin D deficiency during pregnancy is important in order to prevent neonatal vitamin D deficiency and related complications. The aim of the current study is to assess the effect of maternal vitamin D status on the neonatal vitamin D stores. A total of 92 pregnant women at the end of the 3rd trimester and their newborns were recruited from Al Khafji Joint Operation Hospital, Saudi Arabia, during the year 2011. Maternal and cord blood samples were taken for determination of serum levels of circulating 25-hydroxyvitamin D3 [25(OH)D3] concentration, serum calcium (Ca++), phosphorus (PO4) and alkaline phosphatase (ALP). Compared with pregnant women with adequate vitamin D levels, women deficient in vitamin D had infants with vitamin D deficiency (X±SD 33.44±18.33 nmol/L <em>vs</em> 55.39±17.37 nmol/L, P=0.01). Maternal and neonatal serum 25(OH)D3 levels showed a positive correlation with serum Ca++ and negative correlation with serum PO4 and ALP. Neonatal 25(OH)D was related to maternal 3rd trimester levels (r=0.89, P=0.01). The newborn serum 25(OH)D3 concentrations rely on maternal vitamin D status. Poor maternal vitamin D status may adversely affect neonatal vitamin D status and, consequently, calcium homeostasis.


2020 ◽  
Vol 7 (3) ◽  
pp. 582
Author(s):  
Raghvendra Narayan ◽  
Shivani Singh ◽  
Om Prakash Singh

Background: Deficiency of Vitamin D is a prominent health problem globally and its severity is significant in countries like India regardless of age, gender, race and geographical distribution. It is presently the most untreated nutritional deficiency worldwide. Vitamin D during pregnancy has an increasingly recognized range of functions such as  immune modulation, lung development etc. Hence, having the potential to  influence many factors in the developing fetus. Effects of vitamin D deficiency on fetal health is abundant; some being for brief period  of  time  and others may become apparent in later life. Objectives of this study the pattern of vitamin D deficiency in newborns with reference to its gestational age and birth weight.Methods: This was a hospital-based prospective observational study. Total 100 neonates born at MMIMSR, Ambala were enrolled out of which 50 were term and 50 preterm.Results: Out of 100 newborns delivered, 53 newborns were vitamin D deficient. Premature  newborns having 32 (60%) and term newborn having 21 (40%) were found to be deficient in vitamin D. Mean 25 (OH) levels were 21.81 ng/dl.Conclusions: More than half newborns were deficient in vitamin D. Premature newborns had relatively low levels as compared to the term newborns and the  difference  between  two were found  statistically significant.


2011 ◽  
Vol 44 (14) ◽  
pp. 22
Author(s):  
WILLIAM E. GOLDEN ◽  
ROBERT H. HOPKINS

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